| UniProt ID | PHO80_YEAST | |
|---|---|---|
| UniProt AC | P20052 | |
| Protein Name | PHO85 cyclin PHO80 | |
| Gene Name | PHO80 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 293 | |
| Subcellular Localization | Cytoplasm . Nucleus . Localizes predominantly to the cytoplasm under phosphate-rich conditions and concentrates in the nucleus upon phosphate starvation. | |
| Protein Description | Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Negatively regulates the expression of phosphate-starvation-responsive genes under phosphate-rich conditions. The PHO80-PHO85 cyclin-CDK holoenzyme phosphorylates and inactivates the transcription factor PHO4, by preventing its association with the transcription factor PHO2 and the nuclear import receptor PSE1, and by promoting association with the nuclear export receptor MSN5, excluding PHO4 from the nucleus. PHO80-PHO85 phosphorylates and inactivates protein kinase RIM15 by retaining it in the cytoplasm, antagonizing RIM15-induced entry into stationary phase. PHO80-PHO85 also phosphorylates and inactivates the calcineurin-responsive transcription factor CRZ1, linking PHO85 to calcium signaling.. | |
| Protein Sequence | MESTSGERSENIHEDQGIPKVILPADFNKCSRTDLVVLISRMLVSLIAINENSATKKSDDQITLTRYHSKIPPNISIFNYFIRLTKFSSLEHCVLMTSLYYIDLLQTVYPDFTLNSLTAHRFLLTATTVATKGLCDSFSTNAHYAKVGGVRCHELNILENDFLKRVNYRIIPRDHNITLCSIEQKQKKFVIDKNALGSLDLDSYSYVNRPKSGYNVLDKYYRRIVQLVGSFNASPDKSRKVDYVLPPNIDIVSESGSQTTQLKGSSSPNSHSSQKRYSEAKDAHIYNKRSKPD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 53 | Phosphorylation | LIAINENSATKKSDD HHHHCCCCCCCCCCC | 31.01 | 28889911 | |
| 211 | Ubiquitination | YSYVNRPKSGYNVLD CCCCCCCCCCCCHHH | 53.96 | 15699485 | |
| 219 | Ubiquitination | SGYNVLDKYYRRIVQ CCCCHHHHHHHHHHH | 39.77 | 15699485 | |
| 234 | Phosphorylation | LVGSFNASPDKSRKV HHHHCCCCCCCCCCC | 34.43 | 28889911 | |
| 265 | Phosphorylation | QTTQLKGSSSPNSHS CCEECCCCCCCCCHH | 26.51 | 27717283 | |
| 266 | Phosphorylation | TTQLKGSSSPNSHSS CEECCCCCCCCCHHH | 59.49 | 28889911 | |
| 267 | Phosphorylation | TQLKGSSSPNSHSSQ EECCCCCCCCCHHHH | 29.78 | 3283704 | |
| 270 | Phosphorylation | KGSSSPNSHSSQKRY CCCCCCCCHHHHHHH | 28.29 | 27017623 | |
| 277 | Phosphorylation | SHSSQKRYSEAKDAH CHHHHHHHHHHHHHH | 20.21 | 28889911 | |
| 278 | Phosphorylation | HSSQKRYSEAKDAHI HHHHHHHHHHHHHHH | 34.80 | 28889911 |
| Modified Location | Modified Residue | Modification | Function | Reference |
|---|---|---|---|---|
| 267 | S | Phosphorylation |
| 15057567 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PHO80_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
