WHI4_YEAST - dbPTM
WHI4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WHI4_YEAST
UniProt AC Q07655
Protein Name Protein WHI4
Gene Name WHI4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 649
Subcellular Localization Cytoplasm .
Protein Description Has a partially redundant function to WHI3, a dosage-dependent modulator of cell size..
Protein Sequence MSLVHNQTNLNESKFLIERAFSSSSETVPLSKEATYPMPTAYSFSAVRSNSETNIKRENPQGFAKEPIMTSMLHNLTMSTGKGNGNDVNSLAPHDVDVGPYCLLLRNLPKDITLRECYCIFSLATGVSSIELKRDDREPFNDNEKVVVVKFGSLSLVTHYANILNSKSEIFGPSFPFRSHIDVVNEQTQLPVSFQEHVSSGTTNSSPKNYQLSSSAQNEIQNQSFNTISYGKTSSSPLGPSAAKPRPSLLSERSLRFSFNDPFGLETISQRKESVPFLRNSISQHDLSNVTTTPVPAGMPPQKDAGKSLLLLEKDEINESIWNGDELVNDVGNSSFGASLQEPPMSSTPVMEWNASSTANIPLFQLSSQENHQSNLLPPSHHSISQDVPHIQSQPNLNNSGVIHSATSLPHYHLLNQINASTKTQSIQQSVSNVPSNLDLNLQTENGHPQSSAPNGSSIFNNQKVNQGFLVSEQDTSTISRQKECSSTASASAFSKNNETNVAGSTTISQADLSLLAKVPPPANPADQNPPCNTLYVGNLPPDATEQELRQLFSNQQGFRRLSFRNKMNSHGHGNGHGHGPICFVEFEDVSFATRALAELYGSQLPHPRPSLNNKGGIRLSFSKNPLGVRGSNSRSKSGYSFNGSYGKS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSLVHNQTN
------CCCCCCCCC		38.8122369663
22PhosphorylationFLIERAFSSSSETVP
HHHHHHHCCCCCCCC		28.4622369663
23PhosphorylationLIERAFSSSSETVPL
HHHHHHCCCCCCCCC		31.2822369663
24PhosphorylationIERAFSSSSETVPLS
HHHHHCCCCCCCCCC		30.8722369663
25PhosphorylationERAFSSSSETVPLSK
HHHHCCCCCCCCCCC		38.9522369663
27PhosphorylationAFSSSSETVPLSKEA
HHCCCCCCCCCCCCC		29.3922369663
31PhosphorylationSSETVPLSKEATYPM
CCCCCCCCCCCCCCC		23.5219823750
35PhosphorylationVPLSKEATYPMPTAY
CCCCCCCCCCCCCEE		29.2919823750
36PhosphorylationPLSKEATYPMPTAYS
CCCCCCCCCCCCEEC		12.4619823750
40PhosphorylationEATYPMPTAYSFSAV
CCCCCCCCEECCEEE		31.7919823750
42PhosphorylationTYPMPTAYSFSAVRS
CCCCCCEECCEEECC		16.8419823750
43PhosphorylationYPMPTAYSFSAVRSN
CCCCCEECCEEECCC		15.4021440633
45PhosphorylationMPTAYSFSAVRSNSE
CCCEECCEEECCCCC		21.6621440633
49PhosphorylationYSFSAVRSNSETNIK
ECCEEECCCCCCCCC		37.8020377248
51PhosphorylationFSAVRSNSETNIKRE
CEEECCCCCCCCCCC		47.2319823750
53PhosphorylationAVRSNSETNIKRENP
EECCCCCCCCCCCCC		41.9021440633
90PhosphorylationGNGNDVNSLAPHDVD
CCCCCHHHCCCCCCC		26.2521440633
101PhosphorylationHDVDVGPYCLLLRNL
CCCCCHHHHHHHCCC		6.9824930733
110AcetylationLLLRNLPKDITLREC
HHHCCCCCCCCHHHH		66.0025381059
179PhosphorylationGPSFPFRSHIDVVNE
CCCCCCCCCEEECCC		25.7722369663
188PhosphorylationIDVVNEQTQLPVSFQ
EEECCCCCCCCCEEH		26.3722369663
193PhosphorylationEQTQLPVSFQEHVSS
CCCCCCCEEHHHHCC		21.1922369663
199PhosphorylationVSFQEHVSSGTTNSS
CEEHHHHCCCCCCCC		25.5921440633
200PhosphorylationSFQEHVSSGTTNSSP
EEHHHHCCCCCCCCC		38.7822369663
202PhosphorylationQEHVSSGTTNSSPKN
HHHHCCCCCCCCCCC		25.4222369663
203PhosphorylationEHVSSGTTNSSPKNY
HHHCCCCCCCCCCCE		36.3122369663
205PhosphorylationVSSGTTNSSPKNYQL
HCCCCCCCCCCCEEC		46.0220377248
206PhosphorylationSSGTTNSSPKNYQLS
CCCCCCCCCCCEECC		41.8020377248
224PhosphorylationQNEIQNQSFNTISYG
HHHHHCCCCCCEECC		28.1927017623
227PhosphorylationIQNQSFNTISYGKTS
HHCCCCCCEECCCCC		14.8630377154
233PhosphorylationNTISYGKTSSSPLGP
CCEECCCCCCCCCCC		29.4922369663
234PhosphorylationTISYGKTSSSPLGPS
CEECCCCCCCCCCCC		32.1022369663
235PhosphorylationISYGKTSSSPLGPSA
EECCCCCCCCCCCCC		41.0022369663
236PhosphorylationSYGKTSSSPLGPSAA
ECCCCCCCCCCCCCC		24.7422369663
241PhosphorylationSSSPLGPSAAKPRPS
CCCCCCCCCCCCCCC		38.7722369663
248PhosphorylationSAAKPRPSLLSERSL
CCCCCCCCCCCCCEE		43.1329136822
251PhosphorylationKPRPSLLSERSLRFS
CCCCCCCCCCEECEE		35.9424961812
254PhosphorylationPSLLSERSLRFSFND
CCCCCCCEECEECCC		21.6122369663
258PhosphorylationSERSLRFSFNDPFGL
CCCEECEECCCCCCC		19.3922369663
269PhosphorylationPFGLETISQRKESVP
CCCCHHHHHHHHHCC		31.2130377154
274PhosphorylationTISQRKESVPFLRNS
HHHHHHHHCCHHHCC		37.8225533186
281PhosphorylationSVPFLRNSISQHDLS
HCCHHHCCCCHHCCC		19.7222369663
283PhosphorylationPFLRNSISQHDLSNV
CHHHCCCCHHCCCCC		22.6822369663
288PhosphorylationSISQHDLSNVTTTPV
CCCHHCCCCCCCCCC		35.0022369663
291PhosphorylationQHDLSNVTTTPVPAG
HHCCCCCCCCCCCCC		29.2422369663
292PhosphorylationHDLSNVTTTPVPAGM
HCCCCCCCCCCCCCC		25.4822369663
293PhosphorylationDLSNVTTTPVPAGMP
CCCCCCCCCCCCCCC		16.9622369663
308PhosphorylationPQKDAGKSLLLLEKD
CCCCCCCEEEEEEHH		24.2721551504
430PhosphorylationKTQSIQQSVSNVPSN
HHHHHHHHHHCCCCC		15.9021440633
432PhosphorylationQSIQQSVSNVPSNLD
HHHHHHHHCCCCCEE		37.0421551504
436PhosphorylationQSVSNVPSNLDLNLQ
HHHHCCCCCEEEEEE		45.8221440633
476PhosphorylationFLVSEQDTSTISRQK
EEECCCCCCCHHCCH		27.7121440633
478PhosphorylationVSEQDTSTISRQKEC
ECCCCCCCHHCCHHH		25.6821551504
488PhosphorylationRQKECSSTASASAFS
CCHHHCCCCCHHHHC		14.3422369663
490PhosphorylationKECSSTASASAFSKN
HHHCCCCCHHHHCCC		23.8922369663
492PhosphorylationCSSTASASAFSKNNE
HCCCCCHHHHCCCCC		27.6122369663
506PhosphorylationETNVAGSTTISQADL
CCCCCCCEEECHHHH		27.5124961812
507PhosphorylationTNVAGSTTISQADLS
CCCCCCEEECHHHHH		21.9624961812
509PhosphorylationVAGSTTISQADLSLL
CCCCEEECHHHHHHH		19.7524909858
514PhosphorylationTISQADLSLLAKVPP
EECHHHHHHHHCCCC		23.1424961812
621PhosphorylationNKGGIRLSFSKNPLG
CCCCEEEEECCCCCC		20.0221440633
636PhosphorylationVRGSNSRSKSGYSFN
CCCCCCCCCCCCCCC		30.8721440633
638PhosphorylationGSNSRSKSGYSFNGS
CCCCCCCCCCCCCCC		44.1821440633
641PhosphorylationSRSKSGYSFNGSYGK
CCCCCCCCCCCCCCC		18.7630377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WHI4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WHI4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WHI4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC10_YEASTCDC10genetic
17314980
CAF40_YEASTCAF40physical
18467557
NOT3_YEASTNOT3physical
18467557
SIN3_YEASTSIN3genetic
19061648
TMA23_YEASTTMA23genetic
19061648
WHI3_YEASTWHI3genetic
19061648
UTP9_YEASTUTP9genetic
19061648
HPR1_YEASTHPR1genetic
19061648
SAC3_YEASTSAC3genetic
19061648
ERF3_YEASTSUP35genetic
19061648
ARC1_YEASTARC1genetic
19061648
ZDS1_YEASTZDS1genetic
19061648
DUS2_YEASTSMM1genetic
19061648
EAF5_YEASTEAF5genetic
19061648
RU17_YEASTSNP1physical
15687504
RTG3_YEASTRTG3genetic
27708008
AIM4_YEASTAIM4genetic
27708008
FCY2_YEASTFCY2genetic
27708008
AIM11_YEASTAIM11genetic
27708008
YOR1_YEASTYOR1genetic
27708008
DAN1_YEASTDAN1genetic
27708008
DBP7_YEASTDBP7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WHI4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-24; SER-43;SER-51; SER-206; SER-236; SER-283 AND SER-288, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51; SER-281 AND SER-283,AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASSSPECTROMETRY.

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