| UniProt ID | LEM3_YEAST | |
|---|---|---|
| UniProt AC | P42838 | |
| Protein Name | Alkylphosphocholine resistance protein LEM3 | |
| Gene Name | LEM3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 414 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Involved in the asymmetrical organization of phosphatidylethanolamine in the plasma membrane.. | |
| Protein Sequence | MVNFDLGQVGEVFRRKDKGAIVSGDNPEEEEDVDASEFEEDEVKPVRTKNRRPKEDAFTQQRLAAINPVLTPRTVLPLYLLIAVVFVIVGGCILAQNSKVDEVTIYYQDCMTNATSSWSDIPSEHWQFVFHKYKTYNTAPQWRFVDDESDDFTKQRGTCQIRFTTPSDMKNNVYLNYVLEKFAANHRRYVLSFSEDQIRGEDASYETVHDATGINCKPLSKNADGKIYYPCGLIANSMFNDTFPLQLTNVGDTSNNYSLTNKGINWESDKKRYKKTKYNYTQIAPPPYWEKMYPDGYNETNIPDIQDWEEFQNWMRPGAFDKITKLIRINKNDTLPAGEYQLDIGLHWPVLEFNGKKGIYLTHGSHLGGRNPFLGIVYLIGGCICAAMALILLTFWLFGGRKIADASSLSWNMK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Ubiquitination | EVFRRKDKGAIVSGD HHHCCCCCCCEEECC | 53.96 | 23749301 | |
| 23 | Phosphorylation | KDKGAIVSGDNPEEE CCCCCEEECCCCHHH | 34.02 | 28889911 | |
| 36 | Phosphorylation | EEEDVDASEFEEDEV HHCCCCHHHCCCCCC | 38.05 | 22369663 | |
| 48 | Phosphorylation | DEVKPVRTKNRRPKE CCCCCCCCCCCCCCC | 32.67 | 21440633 | |
| 113 | N-linked_Glycosylation | YYQDCMTNATSSWSD EEEHHHCCCCCCCCC | 17.84 | - | |
| 154 | Ubiquitination | DESDDFTKQRGTCQI CCCCCCHHCCCEEEE | 37.68 | 23749301 | |
| 181 | Acetylation | YLNYVLEKFAANHRR EHHHHHHHHHHHCCE | 35.82 | 24489116 | |
| 240 | N-linked_Glycosylation | LIANSMFNDTFPLQL HHHHCCCCCCCCEEE | 38.48 | - | |
| 256 | N-linked_Glycosylation | NVGDTSNNYSLTNKG ECCCCCCCCCCCCCC | 27.77 | - | |
| 279 | N-linked_Glycosylation | RYKKTKYNYTQIAPP HHCCCCCCCCCCCCC | 34.63 | - | |
| 298 | N-linked_Glycosylation | KMYPDGYNETNIPDI HHCCCCCCCCCCCCH | 55.96 | - | |
| 332 | N-linked_Glycosylation | KLIRINKNDTLPAGE EEEEECCCCCCCCEE | 42.91 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LEM3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LEM3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LEM3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36, AND MASSSPECTROMETRY. | |
