SPC98_YEAST - dbPTM
SPC98_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPC98_YEAST
UniProt AC P53540
Protein Name Spindle pole body component SPC98
Gene Name SPC98
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 846
Subcellular Localization Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein Description Involved in microtubule organization by the microtubule organizing center, the spindle pole body (SPB). Probably part of the microtubule attachment site at the SPB..
Protein Sequence MELEPTLFGIIEALAPQLLSQSHLQTFVSDVVNLLRSSTKSATQLGPLIDFYKLQSLDSPETTIMWHKIEKFLDALFGIQNTDDMVKYLSVFQSLLPSNYRAKIVQKSSGLNMENLANHEHLLSPVRAPSIYTEASFENMDRFSERRSMVSSPNRYVPSSTYSSVTLRQLSNPYYVNTIPEEDILKYVSYTLLATTSALFPFDHEQIQIPSKIPNFESGLLHLIFEAGLLYQSLGYKVEKFRMLNISPMKKALIIEISEELQNYTAFVNNLVSSGTVVSLKSLYREIYENIIRLRIYCRFTEHLEELSGDTFLIELNIFKSHGDLTIRKIATNLFNSMISLYYEYLMNWLTKGLLRATYGEFFIAENTDTNGTDDDFIYHIPIEFNQERVPAFIPKELAYKIFMIGKSYIFLEKYCKEVQWTNEFSKKYHVLYQSNSYRGISTNFFEIINDQYSEIVNHTNQILNQKFHYRDVVFALKNILLMGKSDFMDALIEKANDILATPSDSLPNYKLTRVLQEAVQLSSLRHLMNSPRNSSVINGLDARVLDLGHGSVGWDVFTLDYILYPPLSLVLNVNRPFGRKEYLRIFNFLWRFKKNNYFYQKEMLKSNDIIRSFKKIRGYNPLIRDIINKLSRISILRTQFQQFNSKMESYYLNCIIEENFKEMTRKLQRTENKSQNQFDLIRLNNGTIELNGILTPKAEVLTKSSSSKPQKHAIEKTLNIDELESVHNTFLTNILSHKLFATNTSEISVGDYSGQPYPTSLVLLLNSVYEFVKVYCNLNDIGYEIFIKMNLNDHEASNGLLGKFNTNLKEIVSQYKNFKDRLYIFRADLKNDGDEELFLLSKSLR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
108PhosphorylationRAKIVQKSSGLNMEN
HHHEEHHCCCCCHHH		16.7328889911
109PhosphorylationAKIVQKSSGLNMENL
HHEEHHCCCCCHHHH		55.1021700874
124PhosphorylationANHEHLLSPVRAPSI
CCCHHHCCCCCCCCC		27.9221700874
136PhosphorylationPSIYTEASFENMDRF
CCCCCHHCCCCCHHH		27.1928889911
144PhosphorylationFENMDRFSERRSMVS
CCCCHHHHHHHHCCC		30.9621700874
148PhosphorylationDRFSERRSMVSSPNR
HHHHHHHHCCCCCCC		29.7422369663
151PhosphorylationSERRSMVSSPNRYVP
HHHHHCCCCCCCCCC		31.2822369663
152PhosphorylationERRSMVSSPNRYVPS
HHHHCCCCCCCCCCC		18.1322369663
159PhosphorylationSPNRYVPSSTYSSVT
CCCCCCCCCCCCCEE		25.8528889911
160PhosphorylationPNRYVPSSTYSSVTL
CCCCCCCCCCCCEEH		25.8719779198
164PhosphorylationVPSSTYSSVTLRQLS
CCCCCCCCEEHHHCC		14.5425752575
433PhosphorylationSKKYHVLYQSNSYRG
HHHEEEEECCCCCCC		14.6028132839
438PhosphorylationVLYQSNSYRGISTNF
EEECCCCCCCCCCCH		19.6721700874
510PhosphorylationPSDSLPNYKLTRVLQ
CCCCCCCHHHHHHHH		12.8721700874
524PhosphorylationQEAVQLSSLRHLMNS
HHHHHHHHHHHHHCC		37.7121700874
531PhosphorylationSLRHLMNSPRNSSVI
HHHHHHCCCCCHHHH		15.9821700874
703PhosphorylationTPKAEVLTKSSSSKP
CCCEEEECCCCCCCC		33.7727017623
705PhosphorylationKAEVLTKSSSSKPQK
CEEEECCCCCCCCCH		30.1621700874
708PhosphorylationVLTKSSSSKPQKHAI
EECCCCCCCCCHHHH		50.7527017623
831AcetylationYIFRADLKNDGDEEL
EEEEECCCCCCCHHH		54.2424489116
843UbiquitinationEELFLLSKSLR----
HHHHHEECCCC----		54.1824961812
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPC98_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPC98_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPC98_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPC97_YEASTSPC97physical
9130700
SPC97_YEASTSPC97physical
9670012
SPC97_YEASTSPC97physical
9384578
TBG_YEASTTUB4physical
9384578
SP110_YEASTSPC110physical
9693376
TBG_YEASTTUB4physical
8670895
TBG_YEASTTUB4physical
9130700
SPC97_YEASTSPC97genetic
9130700
TBG_YEASTTUB4genetic
9130700
TBG_YEASTTUB4genetic
8670895
SPC72_YEASTSPC72genetic
12970190
APD1_YEASTAPD1physical
16554755
OPLA_YEASTOXP1physical
16554755
CDC73_YEASTCDC73physical
16554755
SPC72_YEASTSPC72physical
16429126
SPC97_YEASTSPC97physical
16429126
TBG_YEASTTUB4physical
16429126
WHI2_YEASTWHI2physical
17634282
CDC5_YEASTCDC5genetic
18178775
TBG_YEASTTUB4physical
18719252
SPC97_YEASTSPC97physical
17978090
SP110_YEASTSPC110physical
17978090
SWE1_YEASTSWE1genetic
15509790
TBG_YEASTTUB4genetic
23825022
NAB3_YEASTNAB3genetic
27708008
STU1_YEASTSTU1genetic
27708008
PDC2_YEASTPDC2genetic
27708008
PSB3_YEASTPUP3genetic
27708008
DAM1_YEASTDAM1genetic
27708008
SPC97_YEASTSPC97genetic
27708008
KTHY_YEASTCDC8genetic
27708008
SSL1_YEASTSSL1genetic
27708008
SPC3_YEASTSPC3genetic
27708008
TYSY_YEASTCDC21genetic
27708008
RPB2_YEASTRPB2genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
MGR1_YEASTMGR1genetic
27708008
SNX41_YEASTSNX41genetic
27708008
SLX8_YEASTSLX8genetic
27708008
RAD4_YEASTRAD4genetic
27708008
MAD1_YEASTMAD1genetic
27708008
BUB1_YEASTBUB1genetic
27708008
MAD2_YEASTMAD2genetic
27708008
SAC1_YEASTSAC1genetic
27708008
RAD14_YEASTRAD14genetic
27708008
BUB3_YEASTBUB3genetic
27708008
RAD1_YEASTRAD1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
VIK1_YEASTVIK1genetic
27708008
YME1_YEASTYME1genetic
27708008
KAR3_YEASTKAR3genetic
27708008
SPC97_YEASTSPC97physical
27226487
DYHC_YEASTDYN1genetic
25971801
SEC66_YEASTSEC66genetic
29674565
KRE28_YEASTKRE28genetic
29674565
KAR3_YEASTKAR3genetic
29674565
PAT1_YEASTPAT1genetic
29674565
RTG2_YEASTRTG2genetic
29674565
STU1_YEASTSTU1genetic
29674565
PPA3_YEASTPHO3genetic
29674565
HNM1_YEASTHNM1genetic
29674565
MAD1_YEASTMAD1genetic
29674565
DAM1_YEASTDAM1genetic
29674565
MAD2_YEASTMAD2genetic
29674565
BUB3_YEASTBUB3genetic
29674565
ARL3_YEASTARL3genetic
29674565
BEM4_YEASTBEM4genetic
29674565
CDC27_YEASTCDC27genetic
29674565
ATG15_YEASTATG15genetic
29674565
DAD1_YEASTDAD1genetic
29674565
ARX1_YEASTARX1genetic
29674565
GPI19_YEASTGPI19genetic
29674565
PAD1_YEASTPAD1genetic
29674565
GDI1_YEASTGDI1genetic
29674565
SGF73_YEASTSGF73genetic
29674565
HOS2_YEASTHOS2genetic
29674565
DSN1_YEASTDSN1genetic
29674565
SPT23_YEASTSPT23genetic
29674565
SMY1_YEASTSMY1genetic
29674565
AP1_YEASTYAP1genetic
29674565
HAS1_YEASTHAS1genetic
29674565
RS28A_YEASTRPS28Agenetic
29674565
MED4_YEASTMED4genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPC98_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124; SER-136; SER-152AND SER-159, AND MASS SPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-151, ANDMASS SPECTROMETRY.

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