BEM4_YEAST - dbPTM
BEM4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BEM4_YEAST
UniProt AC P39011
Protein Name Bud emergence protein 4
Gene Name BEM4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 633
Subcellular Localization
Protein Description Probably acts as a GTPase-activating protein (GAP) for CDC42, RHO1, RHO2, and RHO4. Negative regulator of the pheromone-response pathway through the STE20 protein kinase. Involved in the control of polarized cell growth..
Protein Sequence MDYEEILFGLQPILNASSIKDVPMNDVYLGSYLAVMDQLAVSLREPSNRDIVGKTGLLLNLVRVLEQALDICFHDTSISINDKIAFYEISSEVIRCIANAIIDNDDNREILLDSGGKKLLNYYIGGVLQLDEISSDKSEDSLVDKLQMRSVVLLRNFCIGNLKYTENLAPFIRGPLFVLLKTTQYSYLSSPEKVVLGSDLLNDILKVNYSNVQISDLFFLSQYIKKISSNVQNKELQAMEDGAVEAYSNTETQKFAGQGNQEYIEKEEEDDEEDVNCELLLNLSTCLETIVAKDETINFTNEEQLVLSMQKNLILSLVCLESKTFNNKLIVMRRLISCAGNISANLTNSNKREQSLCIETIKSSASSYALAAALMILCNSVASKSDAVALLKLISLSELIQVGSLLQDPLQYQGFLDLLRKLLNLENTMWLDIKDLFTLFQIMRRCHEQTKYYNNLRSLLTNLLNKTLTVLPSSKIHNSISSDPTIISFIAEHGTLTSCIAMDKLLVSKKALPKEAITSLWDSIFKFQNLGQAEQLSISDLFHITKTVGIYLKDSSVTADVNPIENILFKDYIQKLTLILETILSFKENKDKGSESCFNNGKFIAGIILNIVKNTKCLTPEEQNLEALAKSFF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
134PhosphorylationVLQLDEISSDKSEDS
EEEHHHCCCCCCCCC		30.3629688323
135PhosphorylationLQLDEISSDKSEDSL
EEHHHCCCCCCCCCH		55.5129688323
182PhosphorylationPLFVLLKTTQYSYLS
CEEEEEECCCCHHCC		21.0719823750
183PhosphorylationLFVLLKTTQYSYLSS
EEEEEECCCCHHCCC		24.7519823750
185PhosphorylationVLLKTTQYSYLSSPE
EEEECCCCHHCCCCC		9.3719823750
186PhosphorylationLLKTTQYSYLSSPEK
EEECCCCHHCCCCCE		15.1319823750
187PhosphorylationLKTTQYSYLSSPEKV
EECCCCHHCCCCCEE		12.9819823750
189PhosphorylationTTQYSYLSSPEKVVL
CCCCHHCCCCCEEEE		35.3019823750
190PhosphorylationTQYSYLSSPEKVVLG
CCCHHCCCCCEEEEC		34.1919823750
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BEM4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BEM4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BEM4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SCS3_YEASTSCS3physical
10688190
YL049_YEASTYLR049Cphysical
10688190
RHO1_YEASTRHO1physical
8754840
CDC11_YEASTCDC11physical
11489916
CDC12_YEASTCDC12physical
11489916
SIZ2_YEASTNFI1physical
11489916
SPR28_YEASTSPR28physical
11489916
RHO1_YEASTRHO1genetic
8754840
MSB1_YEASTMSB1genetic
8754839
KPC1_YEASTPKC1genetic
8754840
ROM2_YEASTROM2genetic
8754840
SGE1_YEASTSGE1physical
16554755
RHO1_YEASTRHO1genetic
8754839
CDC42_YEASTCDC42genetic
8754839
BEM1_YEASTBEM1genetic
8754839
BEM2_YEASTBEM2genetic
8754839
CDC42_YEASTCDC42physical
21118957
NBP2_YEASTNBP2physical
21118957
PP2C1_YEASTPTC1physical
21118957
RHO1_YEASTRHO1physical
21118957
KSS1_YEASTKSS1physical
25384973
SHO1_YEASTSHO1physical
25384973
CDC24_YEASTCDC24physical
25384973
STE11_YEASTSTE11genetic
25384973
COPA_YEASTCOP1genetic
27708008
CDC20_YEASTCDC20genetic
27708008
MET30_YEASTMET30genetic
27708008
ATC7_YEASTNEO1genetic
27708008
TIM16_YEASTPAM16genetic
27708008
IMB1_YEASTKAP95genetic
27708008
RPA14_YEASTRPA14genetic
27708008
UME6_YEASTUME6genetic
27708008
LSM6_YEASTLSM6genetic
27708008
UBP6_YEASTUBP6genetic
27708008
SDS3_YEASTSDS3genetic
27708008
IST3_YEASTIST3genetic
27708008
RL40A_YEASTRPL40Bgenetic
27708008
RL40B_YEASTRPL40Bgenetic
27708008
SAM37_YEASTSAM37genetic
27708008
TPM1_YEASTTPM1genetic
27708008
SWM2_YEASTSWM2genetic
27708008
ULS1_YEASTULS1genetic
27708008
CDC24_YEASTCDC24genetic
27708008
UAP1_YEASTQRI1genetic
27708008
PDC2_YEASTPDC2genetic
27708008
TAF12_YEASTTAF12genetic
27708008
TRS23_YEASTTRS23genetic
27708008
TFB1_YEASTTFB1genetic
27708008
COG3_YEASTCOG3genetic
27708008
ACT_YEASTACT1genetic
27708008
STT3_YEASTSTT3genetic
27708008
HSF_YEASTHSF1genetic
27708008
PGTB1_YEASTCDC43genetic
27708008
SEC15_YEASTSEC15genetic
27708008
CBF3A_YEASTCBF2genetic
27708008
RRP3_YEASTRRP3genetic
27708008
DCA13_YEASTSOF1genetic
27708008
GPI13_YEASTGPI13genetic
27708008
SSL1_YEASTSSL1genetic
27708008
SED5_YEASTSED5genetic
27708008
BOS1_YEASTBOS1genetic
27708008
CDC42_YEASTCDC42genetic
27708008
CDC3_YEASTCDC3genetic
27708008
TAF11_YEASTTAF11genetic
27708008
BET5_YEASTBET5genetic
27708008
TAF13_YEASTTAF13genetic
27708008
TAF4_YEASTTAF4genetic
27708008
VTI1_YEASTVTI1genetic
27708008
PRP24_YEASTPRP24genetic
27708008
CAP_YEASTSRV2genetic
27708008
ARPC2_YEASTARC35genetic
27708008
PROF_YEASTPFY1genetic
27708008
SEC63_YEASTSEC63genetic
27708008
MYO2_YEASTMYO2genetic
27708008
LTE1_YEASTLTE1genetic
27708008
PIN4_YEASTPIN4genetic
27708008
SEA4_YEASTSEA4genetic
27708008
EF1A_YEASTTEF2genetic
27708008
STE50_YEASTSTE50genetic
27708008
NAA38_YEASTMAK31genetic
27708008
UFD2_YEASTUFD2genetic
27708008
OST4_YEASTOST4genetic
27708008
MNN10_YEASTMNN10genetic
27708008
MSN5_YEASTMSN5genetic
27708008
YHP1_YEASTYHP1genetic
27708008
PEA2_YEASTPEA2genetic
27708008
MED5_YEASTNUT1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
RSR1_YEASTRSR1genetic
27708008
ELP2_YEASTELP2genetic
27708008
SMI1_YEASTSMI1genetic
27708008
PHB2_YEASTPHB2genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
VPS29_YEASTVPS29genetic
27708008
CYP7_YEASTCPR7genetic
27708008
ILM1_YEASTILM1genetic
27708008
ENT3_YEASTENT3genetic
27708008
CAPZA_YEASTCAP1genetic
27708008
IXR1_YEASTIXR1genetic
27708008
SBA1_YEASTSBA1genetic
27708008
SPA2_YEASTSPA2genetic
27708008
FPS1_YEASTFPS1genetic
27708008
ERG3_YEASTERG3genetic
27708008
BUD6_YEASTBUD6genetic
27708008
ROM2_YEASTROM2genetic
27708008
ELP1_YEASTIKI3genetic
27708008
RCF1_YEASTRCF1genetic
27708008
PYRE_YEASTURA5genetic
27708008
HSC82_YEASTHSC82genetic
27708008
LTN1_YEASTRKR1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
GAS1_YEASTGAS1genetic
27708008
ELP6_YEASTELP6genetic
27708008
DIA1_YEASTDIA1genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
STI1_YEASTSTI1genetic
27708008
VAM10_YEASTVAM10genetic
27708008
VPS5_YEASTVPS5genetic
27708008
VPS17_YEASTVPS17genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BEM4_YEAST

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Related Literatures of Post-Translational Modification

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