SGE1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SGE1_YEAST
• UniProt AC: P33335
• Protein Name: Protein SGE1
• Gene Name: SGE1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 543
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Drug export permease. Multi-copy suppressor of loss-of-function mutation of GAL11. Involved specifically in transcription of GAL4-dependent genes. Can link GAL4 with the basal transcription machinery if GAL11 is missing. Confers resistance to 10-N-nonyl acridine orange (NAO) and in general to cationic dyes..
• Protein Sequence: MKSTLSLTLCVISLLLTLFLAALDIVIVVTLYDTIGIKFHDFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAFCNTSGEPHQKMWLPSKIKKIMNYDYGELLKASFWKNTFEVLVFKLDMVGIILSSAGFTLLMLGLSFGGNNFPWNSGIIICFFTVGPILLLLFCAYDFHFLSLSGLHYDNKRIKPLLTWNIASNCGIFTSSITGFLSCFAYELQSAYLVQLYQLVFKKKPTLASIHLWELSIPAMIATMAIAYLNSKYGIIKPAIVFGVLCGIVGSGLFTLINGELSQSIGYSILPGIAFGSIFQATLLSSQVQITSDDPDFQNKFIEVTAFNSFAKSLGFAFGGNMGAMIFTASLKNQMRSSQLNIPQFTSVETLLAYSTEHYDGPQSSLSKFINTAIHDVFYCALGCYALSFFFGIFTSSKKTTISAKKQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
197	Ubiquitination	QKMWLPSKIKKIMNY HHCCCCHHHHHHHCC	57.51	24961812
200	Ubiquitination	WLPSKIKKIMNYDYG CCCHHHHHHHCCCHH	51.14	23749301
448	Phosphorylation	AFNSFAKSLGFAFGG HHHHHHHHHCCCCCC	30.23	25521595
463	Phosphorylation	NMGAMIFTASLKNQM CHHHHHHHHHHHHHH	12.38	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SGE1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SGE1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SGE1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS8A_YEAST	RPS8A	genetic	20093466
RS8B_YEAST	RPS8A	genetic	20093466
BCS1_YEAST	BCS1	genetic	20093466
YIH7_YEAST	YIL077C	genetic	20093466
PIR5_YEAST	YJL160C	genetic	20093466
MRX5_YEAST	YJL147C	genetic	20093466
GSH1_YEAST	GSH1	genetic	20093466
AIM24_YEAST	AIM24	genetic	20093466
RM49_YEAST	MRP49	genetic	20093466
HAP4_YEAST	HAP4	genetic	20093466
VPS24_YEAST	VPS24	genetic	20093466
RL14A_YEAST	RPL14A	genetic	20093466
DBP7_YEAST	DBP7	genetic	20093466
RL40A_YEAST	RPL40B	genetic	20093466
RL40B_YEAST	RPL40B	genetic	20093466
CST9_YEAST	CST9	genetic	20093466
COX8_YEAST	COX8	genetic	20093466
RCF1_YEAST	RCF1	genetic	20093466
COX5A_YEAST	COX5A	genetic	20093466
ATP23_YEAST	ATP23	genetic	20093466
COQ10_YEAST	COQ10	genetic	20093466
COQ7_YEAST	CAT5	genetic	20093466
HAP5_YEAST	HAP5	genetic	20093466
YME1_YEAST	YME1	genetic	20093466
MST28_YEAST	MST28	physical	16093310
CSG2_YEAST	CSG2	physical	16093310
PHO88_YEAST	PHO88	physical	16093310
MKAR_YEAST	IFA38	physical	16093310
MST27_YEAST	MST27	physical	16093310
VATO_YEAST	VMA16	physical	16093310
SNL1_YEAST	SNL1	physical	16093310
HXT8_YEAST	HXT8	physical	16093310
YET1_YEAST	YET1	physical	16093310
SRPB_YEAST	SRP102	physical	16093310
ZRT3_YEAST	ZRT3	physical	16093310
ELO3_YEAST	ELO3	physical	16093310
GSF2_YEAST	GSF2	physical	16093310
YNJ5_YEAST	YNL095C	physical	16093310
ERP4_YEAST	ERP4	physical	16093310
ATX2_YEAST	ATX2	physical	16093310
ALG5_YEAST	ALG5	physical	16093310
SSB1_YEAST	SSB1	physical	22940862
HSP71_YEAST	SSA1	physical	22940862

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.