PEA2_YEAST - dbPTM
PEA2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PEA2_YEAST
UniProt AC P40091
Protein Name Protein PEA2
Gene Name PEA2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 420
Subcellular Localization
Protein Description Localized to sites of polarized growth and is required for efficient mating and bipolar budding..
Protein Sequence MHKFDLELSRRANPLLFSAERYEEYPLKYDELKQYLLSQNPSHPHHNSRPYTSIDYFDYLLYRSKNDESEIDLDKKLVSEFALYYVQKEHLNSDDLNPTLNELLKLQPKSADWYEMMLRILESINTTGIDQLTKENNNSFPNSKRARSSTNMGGTDKFNKGAYHTDKADDDKNEILQELTSFLMSNSIQKGIDIKPIPLDDPVKFLKNGINSILDTCVSLEKNTSSPPISPNAAAIQEEDSSKKLEELETAFSDLQLAHNFLTKQFENDRAEYVQDIEKLTRTNRELQDKLLNNHSNLSKTEKKLHELEQENKELEKANNKLNSSRHNFGMSSPASSPVTWDPSSPSSVGSPTSGSGSRSLSIMTSEFKKVLTSTQRKYEKELSDEREHRFKLERELALLKNAEANTSLALNRDDPPDML
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
148PhosphorylationPNSKRARSSTNMGGT
CCCCHHCCCCCCCCC		40.3025521595
149PhosphorylationNSKRARSSTNMGGTD
CCCHHCCCCCCCCCC		20.4629136822
150PhosphorylationSKRARSSTNMGGTDK
CCHHCCCCCCCCCCC		30.3919823750
160UbiquitinationGGTDKFNKGAYHTDK
CCCCCCCCCCCCCCC		48.3122106047
163PhosphorylationDKFNKGAYHTDKADD
CCCCCCCCCCCCCCC		17.5819823750
165PhosphorylationFNKGAYHTDKADDDK
CCCCCCCCCCCCCCH		26.9019823750
180PhosphorylationNEILQELTSFLMSNS
HHHHHHHHHHHHHCC		19.3819823750
181PhosphorylationEILQELTSFLMSNSI
HHHHHHHHHHHHCCC		29.0719823750
185PhosphorylationELTSFLMSNSIQKGI
HHHHHHHHCCCCCCC		29.5819823750
187PhosphorylationTSFLMSNSIQKGIDI
HHHHHHCCCCCCCCC		21.0619823750
224PhosphorylationCVSLEKNTSSPPISP
HHHHCCCCCCCCCCC		41.4722369663
225PhosphorylationVSLEKNTSSPPISPN
HHHCCCCCCCCCCCC		50.6825521595
226PhosphorylationSLEKNTSSPPISPNA
HHCCCCCCCCCCCCH		32.4322369663
230PhosphorylationNTSSPPISPNAAAIQ
CCCCCCCCCCHHHHC		20.2022369663
241PhosphorylationAAIQEEDSSKKLEEL
HHHCCCHHHHHHHHH		47.5422890988
242PhosphorylationAIQEEDSSKKLEELE
HHCCCHHHHHHHHHH		46.2422890988
332PhosphorylationSRHNFGMSSPASSPV
HHHCCCCCCCCCCCC		33.2822369663
333PhosphorylationRHNFGMSSPASSPVT
HHCCCCCCCCCCCCC		18.6522369663
336PhosphorylationFGMSSPASSPVTWDP
CCCCCCCCCCCCCCC		38.2621440633
337PhosphorylationGMSSPASSPVTWDPS
CCCCCCCCCCCCCCC		26.0423749301
340PhosphorylationSPASSPVTWDPSSPS
CCCCCCCCCCCCCCC		27.7722369663
344PhosphorylationSPVTWDPSSPSSVGS
CCCCCCCCCCCCCCC		53.0222369663
345PhosphorylationPVTWDPSSPSSVGSP
CCCCCCCCCCCCCCC		33.9022369663
347PhosphorylationTWDPSSPSSVGSPTS
CCCCCCCCCCCCCCC		39.3322369663
348PhosphorylationWDPSSPSSVGSPTSG
CCCCCCCCCCCCCCC		33.6022369663
351PhosphorylationSSPSSVGSPTSGSGS
CCCCCCCCCCCCCCC		23.8922369663
353PhosphorylationPSSVGSPTSGSGSRS
CCCCCCCCCCCCCCC		47.6322369663
354PhosphorylationSSVGSPTSGSGSRSL
CCCCCCCCCCCCCCC		34.0522369663
356PhosphorylationVGSPTSGSGSRSLSI
CCCCCCCCCCCCCEE		33.1022369663
358PhosphorylationSPTSGSGSRSLSIMT
CCCCCCCCCCCEECC		22.0122369663
360PhosphorylationTSGSGSRSLSIMTSE
CCCCCCCCCEECCHH		28.3228132839
362PhosphorylationGSGSRSLSIMTSEFK
CCCCCCCEECCHHHH		16.1521440633
373PhosphorylationSEFKKVLTSTQRKYE
HHHHHHHHHHHHHHH		32.4930377154
407PhosphorylationLKNAEANTSLALNRD
HHCCHHHHHHCCCCC		31.9727017623
408PhosphorylationKNAEANTSLALNRDD
HCCHHHHHHCCCCCC		16.0821551504
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PEA2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PEA2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PEA2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SWE1_YEASTSWE1genetic
12686605
SPA2_YEASTSPA2physical
9632790
GIC2_YEASTGIC2physical
10938101
YM11_YEASTEPO1physical
11087867
SMC3_YEASTSMC3physical
11087867
BEM3_YEASTBEM3genetic
14734532
RAS2_YEASTRAS2genetic
9055077
STE11_YEASTSTE11genetic
9055077
STE12_YEASTSTE12genetic
9055077
SPA2_YEASTSPA2physical
16554755
BUD6_YEASTBUD6physical
19591838
SLA2_YEASTSLA2physical
19591838
ATG14_YEASTATG14physical
22875988
SMY1_YEASTSMY1physical
22875988
BUD6_YEASTBUD6physical
22875988
SLA2_YEASTSLA2physical
22875988
TBP6_YEASTYTA6physical
22875988
NIP80_YEASTNIP100physical
22875988
YP216_YEASTYPL216Wphysical
22875988
BEM3_YEASTBEM3physical
25547157
BUD14_YEASTBUD14physical
25547157
YM11_YEASTEPO1physical
25547157
KEL1_YEASTKEL1physical
25547157
KEL2_YEASTKEL2physical
25547157
MLC1_YEASTMLC1physical
25547157
PEA2_YEASTPEA2physical
25547157
SCS2_YEASTSCS2physical
25547157
SPA2_YEASTSPA2physical
25547157
KIN2_YEASTKIN2physical
27096577
CDC24_YEASTCDC24genetic
27708008
KPC1_YEASTPKC1genetic
27708008
ACT_YEASTACT1genetic
27708008
ARPC2_YEASTARC35genetic
27708008
GPI2_YEASTGPI2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PEA2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-150; THR-224; SER-225;SER-226; SER-230 AND SER-345, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, AND MASSSPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226 AND SER-230, ANDMASS SPECTROMETRY.

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