| UniProt ID | BEM3_YEAST | |
|---|---|---|
| UniProt AC | P32873 | |
| Protein Name | GTPase-activating protein BEM3 | |
| Gene Name | BEM3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1128 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | GTPase-activating protein (GAP) for CDC42 and less efficiently for RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase.. | |
| Protein Sequence | MTDNLTTTHGGSTTLELLAQYNDHRSKKDKSIEHIEKGTCSGKERNPSYDEIFTENIKLKLQVQEYETEIESLEKVIDMLQKNREASLEVVLEQVQNDSRDSYVNDQSFVLPPRSAERKAHIKSLNLPIPTLSPPLQQGSDVALETSVTPTVPQIGVTSNTSISRKHLQNMILNDEIEANSSFSSPKIINRSVSSPTKIHSEQLASPAASVTYTTSRITIKSPNKGSKSPLQERLRSPQNPNRMTAVINNHLHSPLKASTSNNLDELTESKSQQLTNDAIQKNDRVYSSITSSAYTTGTPTSAAKSPSSLLEVKEGENKALGFSPASKEKLDDFTQLLDSSFGEEDLVNTDSKDPLSIKSTINESLPPPPAPPTFFSPTSSGNIKNSTPLSSHLASPVILNKKDDNFGAQSAKNLKKPVLTSSLPNLSTKLSTTSQNASLPPNPPVESSSKQKQLGETASIHSTNTLNTFSSTPQGSLKTLRRPHASSVSTVKSVAQSLKSDIPLFVQPEDFGTIQIEVLSTLYRDNEDDLSILIAIIDRKSGKEMFKFSKSIHKVRELDVYMKSHVPDLPLPTLPDRQLFQTLSPTKVDTRKNILNQYYTSIFSVPEFPKNVGLKIAQFISTDTVMTPPMMDDNVKDGSLLLRRPKTLTGNSTWRVRYGILRDDVLQLFDKNQLTETIKLRQSSIELIPNLPEDRFGTRNGFLITEHKKSGLSTSTKYYICTETSKERELWLSAFSDYIDPSQSLSLSSSRNANDTDSASHLSAGTHHSKFGNATISATDTPSYVTDLTQEYNNNNNISNSSNNIANSDGIDSNPSSHSNFLASSSGNAEEEKDSRRAKMRSLFPFKKLTGPASAMNHIGITISNDSDSPTSPDSIIKSPSKKLMEVSSSSNSSTGPHVSTAIFGSSLETCLRLSSHKYQNVYDLPSVVYRCLEYLYKNRGIQEEGIFRLSGSSTVIKTLQERFDKEYDVDLCRYNESIEAKDDEASPSLYIGVNTVSGLLKLYLRKLPHLLFGDEQFLSFKRVVDENHNNPVQISLGFKELIESGLVPHANLSLMYALFELLVRINENSKFNKMNLRNLCIVFSPTLNIPISMLQPFITDFACIFQGGEPVKEEEREKVDIHIPQV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 31 | Phosphorylation | HRSKKDKSIEHIEKG CCCCCCCCCHHHHCC | 43.26 | 28889911 | |
| 108 | Phosphorylation | DSYVNDQSFVLPPRS CCCCCCCCCCCCCCC | 21.86 | 24961812 | |
| 115 | Phosphorylation | SFVLPPRSAERKAHI CCCCCCCCHHHHHHH | 40.01 | 23749301 | |
| 181 | Phosphorylation | NDEIEANSSFSSPKI CCCHHCCCCCCCCCH | 39.55 | 19684113 | |
| 182 | Phosphorylation | DEIEANSSFSSPKII CCHHCCCCCCCCCHH | 29.02 | 28889911 | |
| 184 | Phosphorylation | IEANSSFSSPKIINR HHCCCCCCCCCHHCC | 47.91 | 24961812 | |
| 185 | Phosphorylation | EANSSFSSPKIINRS HCCCCCCCCCHHCCC | 28.36 | 19684113 | |
| 192 | Phosphorylation | SPKIINRSVSSPTKI CCCHHCCCCCCCCCC | 23.12 | 20377248 | |
| 194 | Phosphorylation | KIINRSVSSPTKIHS CHHCCCCCCCCCCCH | 31.67 | 17330950 | |
| 195 | Phosphorylation | IINRSVSSPTKIHSE HHCCCCCCCCCCCHH | 34.14 | 20377248 | |
| 197 | Phosphorylation | NRSVSSPTKIHSEQL CCCCCCCCCCCHHHH | 44.57 | 20377248 | |
| 201 | Phosphorylation | SSPTKIHSEQLASPA CCCCCCCHHHHCCCC | 30.43 | 21440633 | |
| 206 | Phosphorylation | IHSEQLASPAASVTY CCHHHHCCCCCEEEE | 24.54 | 28152593 | |
| 210 | Phosphorylation | QLASPAASVTYTTSR HHCCCCCEEEEEECE | 19.66 | 28152593 | |
| 212 | Phosphorylation | ASPAASVTYTTSRIT CCCCCEEEEEECEEE | 16.80 | 23749301 | |
| 214 | Phosphorylation | PAASVTYTTSRITIK CCCEEEEEECEEEEE | 14.66 | 24961812 | |
| 215 | Phosphorylation | AASVTYTTSRITIKS CCEEEEEECEEEEEC | 12.95 | 24961812 | |
| 216 | Phosphorylation | ASVTYTTSRITIKSP CEEEEEECEEEEECC | 17.56 | 24961812 | |
| 219 | Phosphorylation | TYTTSRITIKSPNKG EEEECEEEEECCCCC | 22.65 | 21440633 | |
| 222 | Phosphorylation | TSRITIKSPNKGSKS ECEEEEECCCCCCCC | 29.83 | 25533186 | |
| 227 | Phosphorylation | IKSPNKGSKSPLQER EECCCCCCCCHHHHH | 31.41 | 28889911 | |
| 229 | Phosphorylation | SPNKGSKSPLQERLR CCCCCCCCHHHHHHC | 32.32 | 25533186 | |
| 237 | Phosphorylation | PLQERLRSPQNPNRM HHHHHHCCCCCCCCC | 35.11 | 25533186 | |
| 245 | Phosphorylation | PQNPNRMTAVINNHL CCCCCCCHHHHHCCC | 17.97 | 24961812 | |
| 254 | Phosphorylation | VINNHLHSPLKASTS HHHCCCCCCCCCCCC | 37.98 | 21082442 | |
| 259 | Phosphorylation | LHSPLKASTSNNLDE CCCCCCCCCCCCHHH | 30.68 | 21440633 | |
| 260 | Phosphorylation | HSPLKASTSNNLDEL CCCCCCCCCCCHHHH | 40.09 | 29136822 | |
| 261 | Phosphorylation | SPLKASTSNNLDELT CCCCCCCCCCHHHHC | 22.64 | 28889911 | |
| 270 | Phosphorylation | NLDELTESKSQQLTN CHHHHCHHHHHHHHH | 32.16 | 29136822 | |
| 272 | Phosphorylation | DELTESKSQQLTNDA HHHCHHHHHHHHHHH | 32.22 | 29136822 | |
| 276 | Phosphorylation | ESKSQQLTNDAIQKN HHHHHHHHHHHHHHC | 27.07 | 29136822 | |
| 291 | Phosphorylation | DRVYSSITSSAYTTG HHHHHEECCCCCCCC | 20.69 | 27017623 | |
| 295 | Phosphorylation | SSITSSAYTTGTPTS HEECCCCCCCCCCCC | 13.54 | 27017623 | |
| 297 | Phosphorylation | ITSSAYTTGTPTSAA ECCCCCCCCCCCCCC | 26.78 | 27017623 | |
| 299 | Phosphorylation | SSAYTTGTPTSAAKS CCCCCCCCCCCCCCC | 22.69 | 21440633 | |
| 301 | Phosphorylation | AYTTGTPTSAAKSPS CCCCCCCCCCCCCHH | 30.73 | 30377154 | |
| 302 | Phosphorylation | YTTGTPTSAAKSPSS CCCCCCCCCCCCHHH | 27.68 | 21440633 | |
| 306 | Phosphorylation | TPTSAAKSPSSLLEV CCCCCCCCHHHCEEE | 25.86 | 22890988 | |
| 308 | Phosphorylation | TSAAKSPSSLLEVKE CCCCCCHHHCEEEEC | 40.48 | 22890988 | |
| 309 | Phosphorylation | SAAKSPSSLLEVKEG CCCCCHHHCEEEECC | 40.12 | 22369663 | |
| 324 | Phosphorylation | ENKALGFSPASKEKL CCCCCCCCHHHHHHH | 20.12 | 22369663 | |
| 327 | Phosphorylation | ALGFSPASKEKLDDF CCCCCHHHHHHHHHH | 44.74 | 22369663 | |
| 340 | Phosphorylation | DFTQLLDSSFGEEDL HHHHHHHHCCCCCCC | 27.77 | 24961812 | |
| 341 | Phosphorylation | FTQLLDSSFGEEDLV HHHHHHHCCCCCCCC | 36.62 | 21440633 | |
| 377 | Phosphorylation | PAPPTFFSPTSSGNI CCCCCCCCCCCCCCC | 24.07 | 21551504 | |
| 379 | Phosphorylation | PPTFFSPTSSGNIKN CCCCCCCCCCCCCCC | 34.03 | 21551504 | |
| 380 | Phosphorylation | PTFFSPTSSGNIKNS CCCCCCCCCCCCCCC | 39.36 | 27017623 | |
| 381 | Phosphorylation | TFFSPTSSGNIKNST CCCCCCCCCCCCCCC | 38.03 | 27017623 | |
| 387 | Phosphorylation | SSGNIKNSTPLSSHL CCCCCCCCCCCCHHC | 26.80 | 21440633 | |
| 388 | Phosphorylation | SGNIKNSTPLSSHLA CCCCCCCCCCCHHCC | 37.33 | 21440633 | |
| 391 | Phosphorylation | IKNSTPLSSHLASPV CCCCCCCCHHCCCCE | 19.54 | 28152593 | |
| 392 | Phosphorylation | KNSTPLSSHLASPVI CCCCCCCHHCCCCEE | 30.15 | 28152593 | |
| 396 | Phosphorylation | PLSSHLASPVILNKK CCCHHCCCCEECCCC | 26.51 | 28152593 | |
| 421 | Phosphorylation | NLKKPVLTSSLPNLS HCCCCCCCCCCCCCC | 19.26 | 22369663 | |
| 422 | Phosphorylation | LKKPVLTSSLPNLST CCCCCCCCCCCCCCC | 26.22 | 22369663 | |
| 423 | Phosphorylation | KKPVLTSSLPNLSTK CCCCCCCCCCCCCCC | 42.48 | 22369663 | |
| 428 | Phosphorylation | TSSLPNLSTKLSTTS CCCCCCCCCCCCCCC | 30.09 | 22369663 | |
| 429 | Phosphorylation | SSLPNLSTKLSTTSQ CCCCCCCCCCCCCCC | 38.89 | 22369663 | |
| 458 | Phosphorylation | KQKQLGETASIHSTN HCHHHCCCCEEECCC | 24.73 | 21440633 | |
| 460 | Phosphorylation | KQLGETASIHSTNTL HHHCCCCEEECCCCC | 28.40 | 22369663 | |
| 463 | Phosphorylation | GETASIHSTNTLNTF CCCCEEECCCCCCCC | 22.98 | 21440633 | |
| 464 | Phosphorylation | ETASIHSTNTLNTFS CCCEEECCCCCCCCC | 20.33 | 22369663 | |
| 466 | Phosphorylation | ASIHSTNTLNTFSST CEEECCCCCCCCCCC | 22.82 | 22369663 | |
| 469 | Phosphorylation | HSTNTLNTFSSTPQG ECCCCCCCCCCCCCC | 28.18 | 22369663 | |
| 471 | Phosphorylation | TNTLNTFSSTPQGSL CCCCCCCCCCCCCCC | 31.12 | 22369663 | |
| 472 | Phosphorylation | NTLNTFSSTPQGSLK CCCCCCCCCCCCCCH | 39.66 | 22369663 | |
| 473 | Phosphorylation | TLNTFSSTPQGSLKT CCCCCCCCCCCCCHH | 20.59 | 22369663 | |
| 477 | Phosphorylation | FSSTPQGSLKTLRRP CCCCCCCCCHHCCCC | 22.80 | 22369663 | |
| 480 | Phosphorylation | TPQGSLKTLRRPHAS CCCCCCHHCCCCCCC | 30.69 | 24961812 | |
| 487 | Phosphorylation | TLRRPHASSVSTVKS HCCCCCCCCHHHHHH | 28.39 | 15665377 | |
| 488 | Phosphorylation | LRRPHASSVSTVKSV CCCCCCCCHHHHHHH | 22.37 | 21551504 | |
| 490 | Phosphorylation | RPHASSVSTVKSVAQ CCCCCCHHHHHHHHH | 29.45 | 28889911 | |
| 491 | Phosphorylation | PHASSVSTVKSVAQS CCCCCHHHHHHHHHH | 29.78 | 19684113 | |
| 494 | Phosphorylation | SSVSTVKSVAQSLKS CCHHHHHHHHHHHHC | 20.53 | 19684113 | |
| 498 | Phosphorylation | TVKSVAQSLKSDIPL HHHHHHHHHHCCCCE | 28.20 | 28889911 | |
| 574 | Phosphorylation | VPDLPLPTLPDRQLF CCCCCCCCCCCHHHH | 59.62 | 24961812 | |
| 583 | Phosphorylation | PDRQLFQTLSPTKVD CCHHHHHHCCCCCCC | 23.13 | 21440633 | |
| 585 | Phosphorylation | RQLFQTLSPTKVDTR HHHHHHCCCCCCCCH | 33.63 | 25521595 | |
| 587 | Phosphorylation | LFQTLSPTKVDTRKN HHHHCCCCCCCCHHH | 40.08 | 21440633 | |
| 711 | Phosphorylation | LITEHKKSGLSTSTK EEEECCCCCCCCCCC | 50.17 | 30377154 | |
| 720 | Phosphorylation | LSTSTKYYICTETSK CCCCCCEEEEECCCH | 7.35 | 30377154 | |
| 723 | Phosphorylation | STKYYICTETSKERE CCCEEEEECCCHHHH | 32.51 | 30377154 | |
| 757 | Phosphorylation | SSRNANDTDSASHLS CCCCCCCCCCCCCCC | 31.49 | 21082442 | |
| 759 | Phosphorylation | RNANDTDSASHLSAG CCCCCCCCCCCCCCC | 33.49 | 21082442 | |
| 761 | Phosphorylation | ANDTDSASHLSAGTH CCCCCCCCCCCCCCC | 28.98 | 24930733 | |
| 764 | Phosphorylation | TDSASHLSAGTHHSK CCCCCCCCCCCCCCC | 21.16 | 21082442 | |
| 868 | Phosphorylation | GITISNDSDSPTSPD EEEEECCCCCCCCCC | 44.21 | 21440633 | |
| 870 | Phosphorylation | TISNDSDSPTSPDSI EEECCCCCCCCCCHH | 33.75 | 21440633 | |
| 872 | Phosphorylation | SNDSDSPTSPDSIIK ECCCCCCCCCCHHCC | 57.77 | 28889911 | |
| 873 | Phosphorylation | NDSDSPTSPDSIIKS CCCCCCCCCCHHCCC | 30.05 | 24961812 | |
| 876 | Phosphorylation | DSPTSPDSIIKSPSK CCCCCCCHHCCCCCC | 29.60 | 24961812 | |
| 880 | Phosphorylation | SPDSIIKSPSKKLME CCCHHCCCCCCCCEE | 24.81 | 28889911 | |
| 997 | Phosphorylation | SLYIGVNTVSGLLKL CEEEEHHHHHHHHHH | 17.40 | 27017623 | |
| 999 | Phosphorylation | YIGVNTVSGLLKLYL EEEHHHHHHHHHHHH | 22.99 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BEM3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BEM3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BEM3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-324; SER-423 ANDSER-488, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194 AND SER-324, ANDMASS SPECTROMETRY. | |
