RGA1_YEAST - dbPTM
RGA1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGA1_YEAST
UniProt AC P39083
Protein Name Rho-type GTPase-activating protein 1
Gene Name RGA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1007
Subcellular Localization
Protein Description GTPase-activating protein (GAP) for CDC42 and/or RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase; acts at a step between the G-protein and the MAP kinase module. Dominant suppressor of bud emergence defect caused by deletion of IPL2/BEM2. Involved in the control of polarized cell growth and proper bud site selection..
Protein Sequence MASTAPNEQFPSCVRCKEFITTGHAYELGCDRWHTHCFACYKCEKPLSCESDFLVLGTGALICFDCSDSCKNCGKKIDDLAIILSSSNEAYCSDCFKCCKCGENIADLRYAKTKRGLFCLSCHEKLLAKRKYYEEKKRRLKKNLPSLPTPVIDNGHTDEVSASAVLPEKTFSRPASLVNEIPSGSEPSKDIETNSSDIVPHFITGYNDSDDNSGSSKFGSNVSIDVIGPEENSTEHVNDDVKEEAEAPSANMSLNVATDPTLSCKEPPSHSRNLLNKTPLRNSSGQYLAKSPSSYRQGIIVNDSLEESDQIDPPNNSSRNASELLTSVLHSPVSVNMKNPKGSNTDIFNTGEISQMDPSLSRKVLNNIVEETNALQRPVVEVVKEDRSVPDLAGVQQEQAEKYSYSNNSGKGRKISRSLSRRSKDLMINLKSRATGKQDSNVKLSPASKVTSRRSQDLMRDNDSHTGLDTPNSNSTSLDILVNNQKSLNYKRFTDNGTLRVTSGKETALEEQKNHSFKSPSPIDHLLQSPATPSNVSMYRTPPLDSSLTFDRRNGSSYSNQNYSIPSWQKTPKTQLENSDNFEEQKETLYENSESRNDPSLDKEIVTAEHYLKQLKINLKELESQREELMKEITEMKSMKEALRRHIESYNSEKNKLYLDSNELSNNPPMINEISLGESPPVKHVATASSVARSSVKPKFWKFFSSAKPQTEQSIQGVSTNNTNSIVKSAPVLLSAPSSGSNSGRLEISPPVLQNPNEFSDVRLVPIENDANMGQSKDGEEYLDGSNLYGSSLVARCNYENNEIPMILSVCIDFIESDEENMRSEGIYRKSGSQLVIEEIEKQFSAWKVQQNTETPNILTEQDLNVVTGVLKRYLRKLPNPIFTFQIYEPLMRLVKSKKMMENLPFVGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVLRVLSEHIEKVTRYSHWNRMTLYNLALVFAPGLIRDFSGEKDIIDMKERNYIVAFIFGNYKDILT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MASTAPNEQF
-----CCCCCCCCCC		36.6430377154
12PhosphorylationAPNEQFPSCVRCKEF
CCCCCCCCCCCCCCE		26.9130377154
146PhosphorylationRLKKNLPSLPTPVID
HHHHHCCCCCCCCCC		50.5824961812
149PhosphorylationKNLPSLPTPVIDNGH
HHCCCCCCCCCCCCC		35.1721440633
161PhosphorylationNGHTDEVSASAVLPE
CCCCCCCCHHHCCCC		17.9221440633
170PhosphorylationSAVLPEKTFSRPASL
HHCCCCCCCCCCHHH		25.7722890988
172PhosphorylationVLPEKTFSRPASLVN
CCCCCCCCCCHHHHC		42.4522369663
176PhosphorylationKTFSRPASLVNEIPS
CCCCCCHHHHCCCCC		35.2222369663
183PhosphorylationSLVNEIPSGSEPSKD
HHHCCCCCCCCCCCC		61.6922890988
185PhosphorylationVNEIPSGSEPSKDIE
HCCCCCCCCCCCCCC		51.1522890988
188PhosphorylationIPSGSEPSKDIETNS
CCCCCCCCCCCCCCC		38.6222890988
209PhosphorylationFITGYNDSDDNSGSS
HHCCCCCCCCCCCCC		43.1320377248
213PhosphorylationYNDSDDNSGSSKFGS
CCCCCCCCCCCCCCC		47.2321551504
216PhosphorylationSDDNSGSSKFGSNVS
CCCCCCCCCCCCCEE		35.2121551504
220PhosphorylationSGSSKFGSNVSIDVI
CCCCCCCCCEEEEEE		36.8728889911
223PhosphorylationSKFGSNVSIDVIGPE
CCCCCCEEEEEECCC		19.8127717283
234PhosphorylationIGPEENSTEHVNDDV
ECCCCCCCCCCCHHH		41.5128889911
278PhosphorylationSRNLLNKTPLRNSSG
CCCCCCCCCCCCCCC		26.8717330950
283PhosphorylationNKTPLRNSSGQYLAK
CCCCCCCCCCCEECC		29.4321440633
284PhosphorylationKTPLRNSSGQYLAKS
CCCCCCCCCCEECCC		33.2021440633
287PhosphorylationLRNSSGQYLAKSPSS
CCCCCCCEECCCCCC		16.5021440633
291PhosphorylationSGQYLAKSPSSYRQG
CCCEECCCCCCCCCC		25.1425752575
322PhosphorylationNNSSRNASELLTSVL
CCCCCCHHHHHHHHH		32.1215665377
326PhosphorylationRNASELLTSVLHSPV
CCHHHHHHHHHCCCC		29.4322369663
327PhosphorylationNASELLTSVLHSPVS
CHHHHHHHHHCCCCE		23.7422369663
331PhosphorylationLLTSVLHSPVSVNMK
HHHHHHCCCCEECCC		23.8822369663
334PhosphorylationSVLHSPVSVNMKNPK
HHHCCCCEECCCCCC		15.9122369663
337OxidationHSPVSVNMKNPKGSN
CCCCEECCCCCCCCC		4.0915665377
343PhosphorylationNMKNPKGSNTDIFNT
CCCCCCCCCCCCCCC		42.5621440633
345PhosphorylationKNPKGSNTDIFNTGE
CCCCCCCCCCCCCCH		31.9721551504
350PhosphorylationSNTDIFNTGEISQMD
CCCCCCCCCHHHHCC		25.9927017623
359PhosphorylationEISQMDPSLSRKVLN
HHHHCCHHHCHHHHH		34.4121551504
361PhosphorylationSQMDPSLSRKVLNNI
HHCCHHHCHHHHHHH		34.1027017623
372PhosphorylationLNNIVEETNALQRPV
HHHHHHHHCCCCCCE		16.5824961812
388PhosphorylationEVVKEDRSVPDLAGV
EHHCCCCCCCCCCCC		50.7722369663
406PhosphorylationQAEKYSYSNNSGKGR
HHHHHCCCCCCCCCH		24.4828889911
423PhosphorylationSRSLSRRSKDLMINL
HHHHHHHCHHEEHEE		29.4325704821
440PhosphorylationRATGKQDSNVKLSPA
CCCCCCCCCCCCCCH		40.8222369663
445PhosphorylationQDSNVKLSPASKVTS
CCCCCCCCCHHHHCC		16.8322369663
448PhosphorylationNVKLSPASKVTSRRS
CCCCCCHHHHCCHHH		30.9222369663
455PhosphorylationSKVTSRRSQDLMRDN
HHHCCHHHHHHCCCC		27.2525704821
464PhosphorylationDLMRDNDSHTGLDTP
HHCCCCCCCCCCCCC		29.2421551504
470PhosphorylationDSHTGLDTPNSNSTS
CCCCCCCCCCCCCCC		29.4323749301
473PhosphorylationTGLDTPNSNSTSLDI
CCCCCCCCCCCCEEE		33.1021440633
476PhosphorylationDTPNSNSTSLDILVN
CCCCCCCCCEEEEEC		37.2428889911
494PhosphorylationSLNYKRFTDNGTLRV
CCCCEEECCCCEEEE		32.3725704821
503PhosphorylationNGTLRVTSGKETALE
CCEEEECCCCHHHHH		45.0428889911
519PhosphorylationQKNHSFKSPSPIDHL
HHCCCCCCCCHHHHH		28.7122369663
521PhosphorylationNHSFKSPSPIDHLLQ
CCCCCCCCHHHHHHC		41.3922369663
529PhosphorylationPIDHLLQSPATPSNV
HHHHHHCCCCCCCCC		19.2423749301
532PhosphorylationHLLQSPATPSNVSMY
HHHCCCCCCCCCEEC		30.5423749301
537PhosphorylationPATPSNVSMYRTPPL
CCCCCCCEECCCCCC		17.8519779198
541PhosphorylationSNVSMYRTPPLDSSL
CCCEECCCCCCCCCC		16.2728889911
558PhosphorylationDRRNGSSYSNQNYSI
ECCCCCCCCCCCCCC		17.2123749301
564PhosphorylationSYSNQNYSIPSWQKT
CCCCCCCCCCCCCCC		35.2621440633
567PhosphorylationNQNYSIPSWQKTPKT
CCCCCCCCCCCCCCH		40.2321440633
571PhosphorylationSIPSWQKTPKTQLEN
CCCCCCCCCCHHHCC		18.2123749301
574PhosphorylationSWQKTPKTQLENSDN
CCCCCCCHHHCCCCC		39.3221551504
579PhosphorylationPKTQLENSDNFEEQK
CCHHHCCCCCHHHHH		25.2623749301
593PhosphorylationKETLYENSESRNDPS
HHHHHHCCCCCCCCC		25.6320377248
595PhosphorylationTLYENSESRNDPSLD
HHHHCCCCCCCCCCC		35.8821440633
600PhosphorylationSESRNDPSLDKEIVT
CCCCCCCCCCHHHHH		52.6524961812
679PhosphorylationNEISLGESPPVKHVA
CEEECCCCCCCCCEE		32.4828152593
738PhosphorylationPVLLSAPSSGSNSGR
CEEEECCCCCCCCCC		47.2327017623
741PhosphorylationLSAPSSGSNSGRLEI
EECCCCCCCCCCCEE		29.7527214570
743PhosphorylationAPSSGSNSGRLEISP
CCCCCCCCCCCEECC		27.3023749301
749PhosphorylationNSGRLEISPPVLQNP
CCCCCEECCCCCCCC		17.4925752575
912PhosphorylationPFVGGKLSLEAKNSD
CCCCCEEEEEECCCC		27.8728889911
921PhosphorylationEAKNSDTYMSSKSAL
EECCCCCCCCCHHHH		10.4528889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGA1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGA1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGA1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YHE2_YEASTYHL042Wphysical
10688190
ATG36_YEASTATG36physical
10688190
CDC42_YEASTCDC42physical
7498791
CLA4_YEASTCLA4physical
11489916
GIC2_YEASTGIC2physical
11489916
RHO1_YEASTRHO1physical
11489916
CG12_YEASTCLN2physical
15200949
SWC3_YEASTSWC3physical
11087867
BEM3_YEASTBEM3genetic
8657111
RGA2_YEASTRGA2genetic
12455995
PBS2_YEASTPBS2genetic
7498791
CALM_YEASTCMD1physical
16554755
SND1_YEASTYDR186Cphysical
16554755
MLC1_YEASTMLC1physical
16554755
RSB1_YEASTRSB1physical
16554755
ENT1_YEASTENT1physical
16537494
CDC42_YEASTCDC42genetic
8657111
CDC42_YEASTCDC42physical
18166650
MYO2_YEASTMYO2physical
19591838
SLA1_YEASTSLA1genetic
20093466
CYK3_YEASTCYK3genetic
20093466
PP2C1_YEASTPTC1genetic
20093466
SWI5_YEASTSWI5genetic
20093466
NBP2_YEASTNBP2genetic
20093466
MNN10_YEASTMNN10genetic
20093466
IES5_YEASTIES5genetic
20093466
BEM2_YEASTBEM2genetic
20093466
HUR1_YEASTHUR1genetic
20093466
ATC1_YEASTPMR1genetic
20093466
VMA21_YEASTVMA21genetic
20093466
SMI1_YEASTSMI1genetic
20093466
SWE1_YEASTSWE1genetic
20093466
PBS2_YEASTPBS2genetic
20093466
YJ24_YEASTKCH1genetic
20093466
ELM1_YEASTELM1genetic
20093466
HOG1_YEASTHOG1genetic
20093466
ACE2_YEASTACE2genetic
20093466
FKS1_YEASTFKS1genetic
20093466
ROM2_YEASTROM2genetic
20093466
VPS9_YEASTVPS9genetic
20093466
GBLP_YEASTASC1genetic
20093466
GAS1_YEASTGAS1genetic
20093466
EOS1_YEASTEOS1genetic
20093466
AIM44_YEASTAIM44genetic
20093466
SWC3_YEASTSWC3physical
22875988
ADY3_YEASTADY3physical
22875988
MYO2_YEASTMYO2physical
22875988
AMN1_YEASTAMN1genetic
23284084
FLO8_YEASTFLO8genetic
23284084
PBS2_YEASTPBS2genetic
22282571
SWE1_YEASTSWE1genetic
22282571
HOG1_YEASTHOG1genetic
22282571
NBA1_YEASTNBA1genetic
25416945
RSR1_YEASTRSR1genetic
25416945
ECM33_YEASTECM33genetic
27708008
BMT2_YEASTBMT2genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
RXT3_YEASTRXT3genetic
27708008
CYK3_YEASTCYK3genetic
27708008
SWI5_YEASTSWI5genetic
27708008
MNN10_YEASTMNN10genetic
27708008
IES5_YEASTIES5genetic
27708008
BEM2_YEASTBEM2genetic
27708008
MRM2_YEASTMRM2genetic
27708008
ATC1_YEASTPMR1genetic
27708008
SMI1_YEASTSMI1genetic
27708008
GPI7_YEASTLAS21genetic
27708008
PBS2_YEASTPBS2genetic
27708008
YJ24_YEASTKCH1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
ELM1_YEASTELM1genetic
27708008
HOG1_YEASTHOG1genetic
27708008
ACE2_YEASTACE2genetic
27708008
FKS1_YEASTFKS1genetic
27708008
ROM2_YEASTROM2genetic
27708008
UBX2_YEASTUBX2genetic
27708008
VPS9_YEASTVPS9genetic
27708008
GAS1_YEASTGAS1genetic
27708008
AIM44_YEASTAIM44genetic
27708008
CG12_YEASTCLN2physical
25619768
CDC42_YEASTCDC42physical
29074565
NBA1_YEASTNBA1physical
29074565
NIS1_YEASTNIS1physical
29074565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGA1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-278; SER-388; SER-519;SER-521 AND SER-741, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-322, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-278, AND MASSSPECTROMETRY.

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