NIS1_YEAST - dbPTM
NIS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NIS1_YEAST
UniProt AC P53939
Protein Name Protein NIS1
Gene Name NIS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 407
Subcellular Localization Bud neck . Cytoplasm, cell cortex .
Protein Description May be involved in a mitotic signaling network. Binds sumoylated proteins and may stabilize SUMO chains..
Protein Sequence METYETSIGTQSYPPTLFPPPLGTGGFTTSGYIHALVDSTSNSNSNSNTNSNTNSNTNSNSDTKIPIVQISDDSHITHDSFKPYMEYHDASHLRNRNISKADQVESTEVMEQFTQWSNYKMRSRSPTINAKPIRHTSQRRTDFTSKNELSKFSKNHNFIFHKGFLKRQHSIRREDRQAKVRSRFRSKKELTSVLNYIELEQMDIANVLASQPVNLHAIRNLTSRDPAVTPIPFLRSQMYATSSRPPYLRNRSISRKLPKSQPGSLPTTMPATATKTIKQNSTTPTTRSVYNKNVGRSNTSPSVLYHPKRRGKLNTKSHARKEQLLLELWREYLMLVITQRTQLRLTLLCSPGSASNESSVCSSNASDLDMSLLSTPSSLFQMAGETKSNPIIIPDSQDDSILSSDPF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
123PhosphorylationWSNYKMRSRSPTINA
HHCCCCCCCCCCCCC		33.3429136822
125PhosphorylationNYKMRSRSPTINAKP
CCCCCCCCCCCCCCC		27.8629136822
127PhosphorylationKMRSRSPTINAKPIR
CCCCCCCCCCCCCCC		28.2719779198
260PhosphorylationISRKLPKSQPGSLPT
HHCCCCCCCCCCCCC		39.4021440633
264PhosphorylationLPKSQPGSLPTTMPA
CCCCCCCCCCCCCCC		37.5528152593
267PhosphorylationSQPGSLPTTMPATAT
CCCCCCCCCCCCCCC		40.8121440633
268PhosphorylationQPGSLPTTMPATATK
CCCCCCCCCCCCCCC		21.1527017623
272PhosphorylationLPTTMPATATKTIKQ
CCCCCCCCCCCCHHH		29.0521440633
281PhosphorylationTKTIKQNSTTPTTRS
CCCHHHCCCCCCCHH		31.0330377154
282PhosphorylationKTIKQNSTTPTTRSV
CCHHHCCCCCCCHHH		44.3228889911
283PhosphorylationTIKQNSTTPTTRSVY
CHHHCCCCCCCHHHC		20.6121440633
285PhosphorylationKQNSTTPTTRSVYNK
HHCCCCCCCHHHCCC		32.5221551504
297PhosphorylationYNKNVGRSNTSPSVL
CCCCCCCCCCCHHHH		38.2322890988
299PhosphorylationKNVGRSNTSPSVLYH
CCCCCCCCCHHHHCC		43.1722369663
300PhosphorylationNVGRSNTSPSVLYHP
CCCCCCCCHHHHCCC		21.3022369663
302PhosphorylationGRSNTSPSVLYHPKR
CCCCCCHHHHCCCCC		25.2322369663
305PhosphorylationNTSPSVLYHPKRRGK
CCCHHHHCCCCCCCC		17.5822890988
388PhosphorylationQMAGETKSNPIIIPD
HHCCCCCCCCEECCC		56.0821551504
396PhosphorylationNPIIIPDSQDDSILS
CCEECCCCCCCCCCC		30.1021440633
400PhosphorylationIPDSQDDSILSSDPF
CCCCCCCCCCCCCCC		33.4521440633
403PhosphorylationSQDDSILSSDPF---
CCCCCCCCCCCC---		30.9021440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NIS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NIS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NIS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NAP1_YEASTNAP1physical
10688190
SHS1_YEASTSHS1physical
11817649
CDC10_YEASTCDC10physical
11817649
CDC11_YEASTCDC11physical
11817649
CDC12_YEASTCDC12physical
11817649
CDC3_YEASTCDC3physical
11817649
GIN4_YEASTGIN4physical
11817649
KCC4_YEASTKCC4physical
11817649
NAP1_YEASTNAP1physical
11817649
NAP1_YEASTNAP1physical
16554755
NBA1_YEASTNBA1physical
16554755
NAP1_YEASTNAP1physical
16429126
HSP77_YEASTSSC1physical
16429126
NBA1_YEASTNBA1physical
16429126
NAP1_YEASTNAP1physical
11283351
RIM11_YEASTRIM11physical
11283351
ERR1_YEASTERR1physical
18467557
ERR2_YEASTERR1physical
18467557
NAP1_YEASTNAP1physical
18719252
NBA1_YEASTNBA1physical
18719252
RIM11_YEASTRIM11physical
18719252
SMT3_YEASTSMT3physical
18719252
HSP71_YEASTSSA1physical
19536198
AIM44_YEASTAIM44physical
25416945
RL37A_YEASTRPL37Agenetic
27708008
GPR1_YEASTGPR1genetic
27708008
CYK3_YEASTCYK3genetic
27708008
MNN10_YEASTMNN10genetic
27708008
HUR1_YEASTHUR1genetic
27708008
ENO1_YEASTENO1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
ELM1_YEASTELM1genetic
27708008
SIS2_YEASTSIS2genetic
27708008
RIC1_YEASTRIC1genetic
27708008
YL413_YEASTINA1genetic
27708008
RGA1_YEASTRGA1physical
29074565
APC11_YEASTAPC11genetic
29674565
CYK3_YEASTCYK3genetic
29674565
RAD61_YEASTRAD61genetic
29674565
GLPK_YEASTGUT1genetic
29674565
SAC1_YEASTSAC1genetic
29674565
ERG6_YEASTERG6genetic
29674565
ZRC1_YEASTZRC1genetic
29674565
HSP7F_YEASTSSE1genetic
29674565
NAB3_YEASTNAB3genetic
29674565
MAK16_YEASTMAK16genetic
29674565
CSG2_YEASTCSG2genetic
29674565
TRS20_YEASTTRS20genetic
29674565
MXR2_YEASTMXR2genetic
29674565
VAC17_YEASTVAC17genetic
29674565
CSM1_YEASTCSM1genetic
29674565
GET3_YEASTGET3genetic
29674565
DAD1_YEASTDAD1genetic
29674565
ARX1_YEASTARX1genetic
29674565
CDC1_YEASTCDC1genetic
29674565
H2A1_YEASTHTA1genetic
29674565
YD391_YEASTYDR391Cgenetic
29674565
SHO1_YEASTSHO1genetic
29674565
MAD1_YEASTMAD1genetic
29674565
SLX9_YEASTSLX9genetic
29674565
YOR1_YEASTYOR1genetic
29674565
SLT2_YEASTSLT2genetic
29674565
RGI2_YEASTRGI2genetic
29674565
CHS6_YEASTCHS6genetic
29674565
RAV1_YEASTRAV1genetic
29674565
EI2BA_YEASTGCN3genetic
29674565
RIC1_YEASTRIC1genetic
29674565
PPID_YEASTCPR6genetic
29674565
YPT6_YEASTYPT6genetic
29674565
CSM3_YEASTCSM3genetic
29674565
NUP53_YEASTNUP53genetic
29674565
SFL1_YEASTSFL1genetic
29674565
SLP1_YEASTSLP1genetic
29674565
ULA1_YEASTULA1genetic
29674565
SUR1_YEASTSUR1genetic
29674565
YP071_YEASTYPL071Cgenetic
29674565
TBF1_YEASTTBF1genetic
29674565
TGS1_YEASTTGS1genetic
29674565
NCBP2_YEASTCBC2genetic
29674565
OXR1_YEASTOXR1genetic
29674565
RU2A_YEASTLEA1genetic
29674565
NEW1_YEASTNEW1genetic
29674565
YAR1_YEASTYAR1genetic
29674565
BRR1_YEASTBRR1genetic
29674565
ROX1_YEASTROX1genetic
29674565
HDA3_YEASTHDA3genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NIS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-300, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-300, AND MASSSPECTROMETRY.
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-299, AND MASSSPECTROMETRY.

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