EI2BA_YEAST - dbPTM
EI2BA_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EI2BA_YEAST
UniProt AC P14741
Protein Name Translation initiation factor eIF-2B subunit alpha
Gene Name GCN3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 305
Subcellular Localization
Protein Description Acts as a non-essential regulatory component of the translation initiation factor 2B (eIF2-B or GCD complex), which catalyzes the exchange of eukaryotic initiation factor 2 (eIF-2)-bound GDP for GTP and is regulated by phosphorylated eIF-2. It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. Modulation of GCN3 regulatory function in response to amino acid availability occurs post-translationally..
Protein Sequence MSEFNITETYLRFLEEDTEMTMPIAAIEALVTLLRIKTPETAAEMINTIKSSTEELIKSIPNSVSLRAGCDIFMRFVLRNLHLYGDWENCKQHLIENGQLFVSRAKKSRNKIAEIGVDFIADDDIILVHGYSRAVFSLLNHAANKFIRFRCVVTESRPSKQGNQLYTLLEQKGIPVTLIVDSAVGAVIDKVDKVFVGAEGVAESGGIINLVGTYSVGVLAHNARKPFYVVTESHKFVRMFPLSSDDLPMAGPPLDFTRRTDDLEDALRGPTIDYTAQEYITALITDLGVLTPSAVSEELIKMWYD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSEFNITET
------CCCCCCCHH		51.3922814378
37UbiquitinationLVTLLRIKTPETAAE
HHHHHCCCCHHHHHH		52.1423749301
145AcetylationLLNHAANKFIRFRCV
HHHHHHHHHHEEEEE		37.1224489116
225AcetylationVLAHNARKPFYVVTE
HHHCCCCCCEEEEEC		36.7522865919
243PhosphorylationFVRMFPLSSDDLPMA
EEEEEECCCCCCCCC		31.7727017623
244PhosphorylationVRMFPLSSDDLPMAG
EEEEECCCCCCCCCC		42.7127017623
291PhosphorylationITDLGVLTPSAVSEE
HHHHCCCCHHHHCHH		16.8828889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EI2BA_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EI2BA_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EI2BA_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EI2BG_YEASTGCD1physical
11805826
EI2BE_YEASTGCD6physical
11805826
TCPD_YEASTCCT4physical
11805826
CLH_YEASTCHC1physical
11805826
IF2G_YEASTGCD11physical
11805826
EI2BD_YEASTGCD2physical
11805826
EI2BB_YEASTGCD7physical
11805826
GLPK_YEASTGUT1physical
11805826
IF2B_YEASTSUI3physical
11805826
EI2BB_YEASTGCD7physical
11805837
VPS8_YEASTVPS8physical
11805837
TRP_YEASTTRP5physical
11805837
SYFA_YEASTFRS2physical
11805837
ADT2_YEASTPET9physical
11805837
GPN1_YEASTNPA3physical
11805837
CBP6_YEASTCBP6physical
11805837
NDH1_YEASTNDE1physical
11805837
HXT7_YEASTHXT7physical
11805837
PLSC_YEASTSLC1physical
11805837
BGL2_YEASTBGL2physical
11805837
CLPX_YEASTMCX1physical
11805837
PET10_YEASTPET10physical
11805837
TRPG_YEASTTRP3physical
11805837
IF2G_YEASTGCD11physical
11805837
LCF1_YEASTFAA1physical
11805837
GUF1_YEASTGUF1physical
11805837
YHM2_YEASTYHM2physical
11805837
MKT1_YEASTMKT1physical
11805837
VATD_YEASTVMA8physical
11805837
EI2BE_YEASTGCD6physical
11805837
EI2BD_YEASTGCD2physical
11805837
EI2BG_YEASTGCD1physical
11805837
BIT2_YEASTBIT2physical
11283351
EI2BA_YEASTGCN3physical
10688190
EI2BE_YEASTGCD6physical
8336705
EI2BB_YEASTGCD7physical
8336705
GCN2_YEASTGCN2genetic
3540603
TRM6_YEASTGCD10genetic
3540603
IF2G_YEASTGCD11genetic
3540603
EI2BD_YEASTGCD2genetic
3540603
EI2BE_YEASTGCD6genetic
8336705
EI2BB_YEASTGCD7genetic
8336705
IF2A_YEASTSUI2genetic
2678106
EI2BD_YEASTGCD2genetic
8336705
IF2B_YEASTSUI3genetic
8102207
TRM61_YEASTGCD14genetic
9539420
GCN4_YEASTGCN4genetic
6351059
AP2A_YEASTAPL3physical
16554755
EI2BD_YEASTGCD2physical
16554755
AAP1_YEASTAAP1physical
16554755
TCPD_YEASTCCT4physical
16429126
EI2BG_YEASTGCD1physical
16429126
IF2G_YEASTGCD11physical
16429126
EI2BD_YEASTGCD2physical
16429126
EI2BE_YEASTGCD6physical
16429126
EI2BB_YEASTGCD7physical
16429126
IF2B_YEASTSUI3physical
16429126
EI2BA_YEASTGCN3physical
11283351
EI2BB_YEASTGCD7physical
18467557
SYDC_YEASTDPS1genetic
19061648
CDC73_YEASTCDC73genetic
19061648
RPB1_YEASTRPO21genetic
19061648
RRP8_YEASTRRP8genetic
19061648
ERF3_YEASTSUP35genetic
19061648
EI2BE_YEASTGCD6genetic
19061648
SEM1_YEASTSEM1genetic
19061648
NOP3_YEASTNPL3genetic
19061648
SYNC_YEASTDED81genetic
19061648
IF2G_YEASTGCD11genetic
19061648
LCP5_YEASTLCP5genetic
19061648
CWC21_YEASTCWC21genetic
19061648
IF2M_YEASTIFM1genetic
19061648
HIR2_YEASTHIR2genetic
19061648
CSK22_YEASTCKA2genetic
19061648
EI2BA_YEASTGCN3physical
18719252
CWC21_YEASTCWC21genetic
19547744
RNH2A_YEASTRNH201genetic
19547744
HIR2_YEASTHIR2genetic
19547744
ZDS1_YEASTZDS1genetic
19547744
RTG3_YEASTRTG3genetic
20093466
ETR1_YEASTETR1genetic
20093466
HOSC_YEASTLYS20genetic
20093466
PHO2_YEASTPHO2genetic
20093466
RTG2_YEASTRTG2genetic
20093466
HTD2_YEASTHTD2genetic
20093466
LPLA_YEASTAIM22genetic
20093466
PTK2_YEASTPTK2genetic
20093466
ALAM_YEASTALT1genetic
20093466
LIPB_YEASTLIP2genetic
20093466
MKS1_YEASTMKS1genetic
20093466
RTG1_YEASTRTG1genetic
20093466
LIPA_YEASTLIP5genetic
20093466
CHMU_YEASTARO7genetic
20093466
EI2BD_YEASTGCD2genetic
3319768
EI2BG_YEASTGCD1genetic
3319768
SLT2_YEASTSLT2physical
21376235
EI2BA_YEASTGCN3physical
24771766
CDC37_YEASTCDC37genetic
27708008
TFB1_YEASTTFB1genetic
27708008
PANK_YEASTCAB1genetic
27708008
IF2A_YEASTSUI2genetic
27708008
EI2BB_YEASTGCD7genetic
27708008
EI2BG_YEASTGCD1genetic
27708008
PHO2_YEASTPHO2genetic
27708008
HOSC_YEASTLYS20genetic
27708008
YD183_YEASTYDL183Cgenetic
27708008
AROC_YEASTARO2genetic
27708008
RTG2_YEASTRTG2genetic
27708008
LPLA_YEASTAIM22genetic
27708008
LIPB_YEASTLIP2genetic
27708008
MKS1_YEASTMKS1genetic
27708008
RTG1_YEASTRTG1genetic
27708008
LIPA_YEASTLIP5genetic
27708008
CHMU_YEASTARO7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EI2BA_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-291, AND MASSSPECTROMETRY.

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