NDH1_YEAST - dbPTM
NDH1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NDH1_YEAST
UniProt AC P40215
Protein Name External NADH-ubiquinone oxidoreductase 1, mitochondrial
Gene Name NDE1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 560
Subcellular Localization Mitochondrion intermembrane space .
Protein Description External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE2, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxidation..
Protein Sequence MIRQSLMKTVWANSSRFSLQSKSGLVKYAKNRSFHAARNLLEDKKVILQKVAPTTGVVAKQSFFKRTGKFTLKALLYSALAGTAYVSYSLYREANPSTQVPQSDTFPNGSKRKTLVILGSGWGSVSLLKNLDTTLYNVVVVSPRNYFLFTPLLPSTPVGTIELKSIVEPVRTIARRSHGEVHYYEAEAYDVDPENKTIKVKSSAKNNDYDLDLKYDYLVVGVGAQPNTFGTPGVYEYSSFLKEISDAQEIRLKIMSSIEKAASLSPKDPERARLLSFVVVGGGPTGVEFAAELRDYVDQDLRKWMPELSKEIKVTLVEALPNILNMFDKYLVDYAQDLFKEEKIDLRLKTMVKKVDATTITAKTGDGDIENIPYGVLVWATGNAPREVSKNLMTKLEEQDSRRGLLIDNKLQLLGAKGSIFAIGDCTFHPGLFPTAQVAHQEGEYLAQYFKKAYKIDQLNWKMTHAKDDSEVARLKNQIVKTQSQIEDFKYNHKGALAYIGSDKAIADLAVGEAKYRLAGSFTFLFWKSAYLAMCLSFRNRVLVAMDWAKVYFLGRDSSI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
50AcetylationDKKVILQKVAPTTGV
CCHHHHHHHCCCCCE		36.6024489116
502-HydroxyisobutyrylationDKKVILQKVAPTTGV
CCHHHHHHHCCCCCE		36.60-
50UbiquitinationDKKVILQKVAPTTGV
CCHHHHHHHCCCCCE		36.6017644757
55PhosphorylationLQKVAPTTGVVAKQS
HHHHCCCCCEEECHH		27.2427017623
60AcetylationPTTGVVAKQSFFKRT
CCCCEEECHHHHHHC		34.5624489116
60UbiquitinationPTTGVVAKQSFFKRT
CCCCEEECHHHHHHC		34.5617644757
111UbiquitinationDTFPNGSKRKTLVIL
CCCCCCCCCCEEEEE		60.3517644757
113UbiquitinationFPNGSKRKTLVILGS
CCCCCCCCEEEEECC		50.3617644757
129UbiquitinationWGSVSLLKNLDTTLY
CCHHHHHHCCCCCEE		61.8417644757
164UbiquitinationPVGTIELKSIVEPVR
CCEEEEEHHHCHHHH		25.9117644757
1992-HydroxyisobutyrylationDPENKTIKVKSSAKN
CCCCCEEEEEECCCC		49.17-
205SuccinylationIKVKSSAKNNDYDLD
EEEEECCCCCCCCCC		59.2223954790
310AcetylationKWMPELSKEIKVTLV
HHCHHHHHHHCHHHH		75.8824489116
329UbiquitinationNILNMFDKYLVDYAQ
HHHHHHHHHHHHHHH		29.2617644757
340AcetylationDYAQDLFKEEKIDLR
HHHHHHHHHHCCHHH		72.7224489116
340UbiquitinationDYAQDLFKEEKIDLR
HHHHHHHHHHCCHHH		72.7217644757
343UbiquitinationQDLFKEEKIDLRLKT
HHHHHHHCCHHHHHH		42.4817644757
353UbiquitinationLRLKTMVKKVDATTI
HHHHHHEEEECCEEE		35.9417644757
354UbiquitinationRLKTMVKKVDATTIT
HHHHHEEEECCEEEE		33.6617644757
363UbiquitinationDATTITAKTGDGDIE
CCEEEEEECCCCCHH		44.3717644757
410AcetylationRGLLIDNKLQLLGAK
CCEEHHHHHHHHCCC		33.5824489116
410UbiquitinationRGLLIDNKLQLLGAK
CCEEHHHHHHHHCCC		33.5817644757
417UbiquitinationKLQLLGAKGSIFAIG
HHHHHCCCCCEEEEE		51.9317644757
451UbiquitinationEYLAQYFKKAYKIDQ
HHHHHHHHHHHCHHH		31.4017644757
452UbiquitinationYLAQYFKKAYKIDQL
HHHHHHHHHHCHHHC		47.2317644757
462AcetylationKIDQLNWKMTHAKDD
CHHHCCCCCCCCCCH		32.6124489116
462UbiquitinationKIDQLNWKMTHAKDD
CHHHCCCCCCCCCCH		32.6117644757
467UbiquitinationNWKMTHAKDDSEVAR
CCCCCCCCCHHHHHH		55.2317644757
481UbiquitinationRLKNQIVKTQSQIED
HHHHHHHHCHHHHHC		42.3417644757
484PhosphorylationNQIVKTQSQIEDFKY
HHHHHCHHHHHCCCC		38.0530377154
490AcetylationQSQIEDFKYNHKGAL
HHHHHCCCCCCCCCE		58.4224489116
490UbiquitinationQSQIEDFKYNHKGAL
HHHHHCCCCCCCCCE		58.4217644757
494UbiquitinationEDFKYNHKGALAYIG
HCCCCCCCCCEEEEC		42.0917644757
504AcetylationLAYIGSDKAIADLAV
EEEECCCHHHHHHHH		43.3124489116
5152-HydroxyisobutyrylationDLAVGEAKYRLAGSF
HHHHHHHHHHHCCEE		26.97-
515AcetylationDLAVGEAKYRLAGSF
HHHHHHHHHHHCCEE		26.9724489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NDH1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NDH1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NDH1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NDH2_YEASTNDE2genetic
9733747
NDH2_YEASTNDE2genetic
18408719
ODO2_YEASTKGD2genetic
20093466
CSN11_YEASTPCI8genetic
20093466
IDH1_YEASTIDH1genetic
20093466
WHI2_YEASTWHI2genetic
20093466
CEM1_YEASTCEM1genetic
21623372
QCR9_YEASTQCR9genetic
21623372
NDI1_YEASTNDI1genetic
23116202
COQ10_YEASTCOQ10genetic
23116202
COQ4_YEASTCOQ4genetic
23116202
VMA21_YEASTVMA21genetic
27708008
IDH1_YEASTIDH1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NDH1_YEAST

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Related Literatures of Post-Translational Modification

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