| UniProt ID | NDH2_YEAST | |
|---|---|---|
| UniProt AC | Q07500 | |
| Protein Name | External NADH-ubiquinone oxidoreductase 2, mitochondrial | |
| Gene Name | NDE2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 545 | |
| Subcellular Localization | Mitochondrion intermembrane space . | |
| Protein Description | External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE1, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxidation.. | |
| Protein Sequence | MLPRLGFARTARSIHRFKMTQISKPFFHSTEVGKPGPQQKLSKSYTAVFKKWFVRGLKLTFYTTLAGTLYVSYELYKESNPPKQVPQSTAFANGLKKKELVILGTGWGAISLLKKLDTSLYNVTVVSPRSFFLFTPLLPSTPVGTIEMKSIVEPVRSIARRTPGEVHYIEAEALDVDPKAKKVMVQSVSEDEYFVSSLSYDYLVVSVGAKTTTFNIPGVYGNANFLKEIEDAQNIRMKLMKTIEQASSFPVNDPERKRLLTFVVVGGGPTGVEFAAELQDYINQDLRKWMPDLSKEMKVILIEALPNILNMFDKTLIKYAEDLFARDEIDLQVNTAVKVVEPTYIRTLQNGQTNTDIEYGMLVWATGNEPIDFSKTLMSRIPEQTNRRGLLINDKLELLGSENSIYAIGDCTAHTGFFPTAQVAHQEGEYLAKILDKKLQIEQLEWDMLNSTDETEVSRLQKEVNLRKSKLDKFNYKHMGALAYIGSETAIADLHMGDSSYQLKGMFAFLFWKSAYLAMCLSIRNRILIAMDWTKVYFLGRDSSV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 79 | Phosphorylation | SYELYKESNPPKQVP EEEHHHHCCCCCCCC | 50.95 | 19795423 | |
| 88 | Phosphorylation | PPKQVPQSTAFANGL CCCCCCCHHHHHCCC | 18.68 | 19795423 | |
| 89 | Phosphorylation | PKQVPQSTAFANGLK CCCCCCHHHHHCCCC | 22.13 | 19795423 | |
| 376 | Phosphorylation | EPIDFSKTLMSRIPE CCCCCCHHHHHCCCC | 26.88 | 30377154 | |
| 385 | Phosphorylation | MSRIPEQTNRRGLLI HHCCCCCCCCCCCEE | 29.09 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NDH2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NDH2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NDH2_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GGC1_YEAST | GGC1 | physical | 18467557 | |
| SWT21_YEAST | SWT21 | physical | 18467557 | |
| CSG2_YEAST | CSG2 | genetic | 21623372 | |
| QCR7_YEAST | QCR7 | genetic | 21623372 | |
| ELO3_YEAST | ELO3 | genetic | 21623372 | |
| AATC_YEAST | AAT2 | genetic | 21623372 | |
| ENV10_YEAST | ENV10 | genetic | 27708008 | |
| BUD21_YEAST | BUD21 | genetic | 27708008 | |
| SIA1_YEAST | SIA1 | genetic | 27708008 | |
| MSC6_YEAST | MSC6 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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