GGC1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GGC1_YEAST
• UniProt AC: P38988
• Protein Name: Mitochondrial GTP/GDP carrier protein 1
• Gene Name: GGC1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 300
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Mitochondrial GTP/GDP transporter required for GTP uptake and GDP exit from mitochondria. Involved in mitochondrial iron transport and essential for mitochondrial genome maintenance..
• Protein Sequence: MPHTDKKQSGLARLLGSASAGIMEIAVFHPVDTISKRLMSNHTKITSGQELNRVIFRDHFSEPLGKRLFTLFPGLGYAASYKVLQRVYKYGGQPFANEFLNKHYKKDFDNLFGEKTGKAMRSAAAGSLIGIGEIVLLPLDVLKIKRQTNPESFKGRGFIKILRDEGLFNLYRGWGWTAARNAPGSFALFGGNAFAKEYILGLKDYSQATWSQNFISSIVGACSSLIVSAPLDVIKTRIQNRNFDNPESGLRIVKNTLKNEGVTAFFKGLTPKLLTTGPKLVFSFALAQSLIPRFDNLLSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	MSNHTKITSGQELNR HCCCCCCCCCCHHHH	28.49	25521595
61	Phosphorylation	VIFRDHFSEPLGKRL HHHHHCCCCCHHHHH	34.58	25521595
82	Ubiquitination	LGYAASYKVLQRVYK CCHHHHHHHHHHHHH	33.69	17644757
82	Acetylation	LGYAASYKVLQRVYK CCHHHHHHHHHHHHH	33.69	24489116
89	Ubiquitination	KVLQRVYKYGGQPFA HHHHHHHHHCCCCCH	34.26	17644757
89	Acetylation	KVLQRVYKYGGQPFA HHHHHHHHHCCCCCH	34.26	24489116
102	Ubiquitination	FANEFLNKHYKKDFD CHHHHHHHHHHHHHH	50.92	17644757
102	Acetylation	FANEFLNKHYKKDFD CHHHHHHHHHHHHHH	50.92	24489116
106	Acetylation	FLNKHYKKDFDNLFG HHHHHHHHHHHHHCC	57.36	24489116
115	Acetylation	FDNLFGEKTGKAMRS HHHHCCHHHHHHHHH	64.06	24489116
160	Ubiquitination	FKGRGFIKILRDEGL HCCCCCEEEHHCCCC	33.17	17644757
267	Acetylation	EGVTAFFKGLTPKLL CCCHHHHCCCCHHHH	46.70	24489116
272	Acetylation	FFKGLTPKLLTTGPK HHCCCCHHHHCCCCH	51.39	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GGC1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GGC1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GGC1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC13_YEAST	UBC13	physical	18467557
CMC1_YEAST	SAL1	genetic	18431598
MPCP_YEAST	MIR1	genetic	21189251
SRS2_YEAST	SRS2	genetic	21459050

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.