| UniProt ID | IDH1_YEAST | |
|---|---|---|
| UniProt AC | P28834 | |
| Protein Name | Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial | |
| Gene Name | IDH1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 360 | |
| Subcellular Localization | Mitochondrion. | |
| Protein Description | Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.. | |
| Protein Sequence | MLNRTIAKRTLATAAQAERTLPKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 41 | Acetylation | IPGDGVGKEITDSVR ECCCCCCHHHHHHHH | 43.46 | 24489116 | |
| 66 | Acetylation | DWETINIKQTDHKEG CCEEEEEECCCCCCC | 42.53 | 24489116 | |
| 71 | Acetylation | NIKQTDHKEGVYEAV EEECCCCCCCHHHHH | 60.00 | 24489116 | |
| 75 | Phosphorylation | TDHKEGVYEAVESLK CCCCCCHHHHHHHHH | 14.72 | 22369663 | |
| 80 | Phosphorylation | GVYEAVESLKRNKIG CHHHHHHHHHHCCCC | 32.37 | 22369663 | |
| 82 | Acetylation | YEAVESLKRNKIGLK HHHHHHHHHCCCCCC | 64.30 | 24489116 | |
| 143 | Phosphorylation | LIVIRENTEGEFSGL EEEEECCCCCCCCCC | 40.38 | 30377154 | |
| 182 | Acetylation | RFAFDFAKKYNRKSV HHHHHHHHHCCCCCC | 56.64 | 24489116 | |
| 188 | Phosphorylation | AKKYNRKSVTAVHKA HHHCCCCCCHHHHHH | 22.82 | 28889911 | |
| 199 | Acetylation | VHKANIMKLGDGLFR HHHHCHHHHCCHHHH | 45.59 | 24489116 | |
| 324 | Acetylation | EYATRISKAVHETIA HHHHHHHHHHHHHHH | 52.65 | 22865919 | |
| 334 | Acetylation | HETIAEGKHTTRDIG HHHHHCCCCCCCCCC | 29.32 | 22865919 | |
| 337 | Phosphorylation | IAEGKHTTRDIGGSS HHCCCCCCCCCCCCC | 26.51 | 27017623 | |
| 343 | Phosphorylation | TTRDIGGSSSTTDFT CCCCCCCCCCCHHHH | 18.86 | 22369663 | |
| 344 | Phosphorylation | TRDIGGSSSTTDFTN CCCCCCCCCCHHHHH | 34.67 | 22369663 | |
| 345 | Phosphorylation | RDIGGSSSTTDFTNE CCCCCCCCCHHHHHH | 36.70 | 22369663 | |
| 346 | Phosphorylation | DIGGSSSTTDFTNEI CCCCCCCCHHHHHHH | 32.12 | 29734811 | |
| 347 | Phosphorylation | IGGSSSTTDFTNEII CCCCCCCHHHHHHHH | 30.94 | 22369663 | |
| 358 | Phosphorylation | NEIINKLSTM----- HHHHHHHHCC----- | 24.84 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IDH1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IDH1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IDH1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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