CISY2_YEAST - dbPTM
CISY2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CISY2_YEAST
UniProt AC P08679
Protein Name Citrate synthase, peroxisomal
Gene Name CIT2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 460
Subcellular Localization Peroxisome.
Protein Description
Protein Sequence MTVPYLNSNRNVASYLQSNSSQEKTLKERFSEIYPIHAQDVRQFVKEHGKTKISDVLLEQVYGGMRGIPGSVWEGSVLDPEDGIRFRGRTIADIQKDLPKAKGSSQPLPEALFWLLLTGEVPTQAQVENLSADLMSRSELPSHVVQLLDNLPKDLHPMAQFSIAVTALESESKFAKAYAQGISKQDYWSYTFEDSLDLLGKLPVIAAKIYRNVFKDGKMGEVDPNADYAKNLVNLIGSKDEDFVDLMRLYLTIHSDHEGGNVSAHTSHLVGSALSSPYLSLASGLNGLAGPLHGRANQEVLEWLFALKEEVNDDYSKDTIEKYLWDTLNSGRVIPGYGHAVLRKTDPRYMAQRKFAMDHFPDYELFKLVSSIYEVAPGVLTEHGKTKNPWPNVDAHSGVLLQYYGLKESSFYTVLFGVSRAFGILAQLITDRAIGASIERPKSYSTEKYKELVKNIESKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTVPYLNSN
------CCCCCCCCC		30.1324961812
5Phosphorylation---MTVPYLNSNRNV
---CCCCCCCCCCCH		17.7424961812
8PhosphorylationMTVPYLNSNRNVASY
CCCCCCCCCCCHHHH		34.2724961812
14PhosphorylationNSNRNVASYLQSNSS
CCCCCHHHHHHCCCC		23.3027214570
15PhosphorylationSNRNVASYLQSNSSQ
CCCCHHHHHHCCCCC		10.0624961812
18PhosphorylationNVASYLQSNSSQEKT
CHHHHHHCCCCCHHH		35.7627214570
20PhosphorylationASYLQSNSSQEKTLK
HHHHHCCCCCHHHHH		38.3524961812
21PhosphorylationSYLQSNSSQEKTLKE
HHHHCCCCCHHHHHH		46.7625752575
24UbiquitinationQSNSSQEKTLKERFS
HCCCCCHHHHHHHHH		52.0717644757
27UbiquitinationSSQEKTLKERFSEIY
CCCHHHHHHHHHHHC		52.6717644757
50UbiquitinationQFVKEHGKTKISDVL
HHHHHHCCCCHHHHH		48.8622817900
52UbiquitinationVKEHGKTKISDVLLE
HHHHCCCCHHHHHHH		43.6424961812
96UbiquitinationRTIADIQKDLPKAKG
EEHHHHHHHCCCCCC		62.6624961812
100UbiquitinationDIQKDLPKAKGSSQP
HHHHHCCCCCCCCCC		70.7622817900
102UbiquitinationQKDLPKAKGSSQPLP
HHHCCCCCCCCCCCH		66.5015699485
153UbiquitinationQLLDNLPKDLHPMAQ
HHHHCCCCCCCHHHH		75.8917644757
173UbiquitinationTALESESKFAKAYAQ
HHHHCHHHHHHHHHC		45.3422817900
176UbiquitinationESESKFAKAYAQGIS
HCHHHHHHHHHCCCC		45.0923749301
184UbiquitinationAYAQGISKQDYWSYT
HHHCCCCCCCCCCEE		45.3118433149
201UbiquitinationDSLDLLGKLPVIAAK
HHHHHHCCCHHHHHH		49.9717644757
208UbiquitinationKLPVIAAKIYRNVFK
CCHHHHHHHHHHHHC		31.1124961812
215UbiquitinationKIYRNVFKDGKMGEV
HHHHHHHCCCCCCCC		62.3824961812
218UbiquitinationRNVFKDGKMGEVDPN
HHHHCCCCCCCCCCC		54.5923749301
230UbiquitinationDPNADYAKNLVNLIG
CCCHHHHHHHHHHHC		44.5824961812
239UbiquitinationLVNLIGSKDEDFVDL
HHHHHCCCCHHHHHH		60.9823749301
308UbiquitinationLEWLFALKEEVNDDY
HHHHHHHHHHHCCCC		48.6917644757
317UbiquitinationEVNDDYSKDTIEKYL
HHCCCCCHHHHHHHH		53.3017644757
322UbiquitinationYSKDTIEKYLWDTLN
CCHHHHHHHHHHHHH		41.6217644757
327PhosphorylationIEKYLWDTLNSGRVI
HHHHHHHHHHCCCCC		19.0925882841
330PhosphorylationYLWDTLNSGRVIPGY
HHHHHHHCCCCCCCC		30.9625882841
344UbiquitinationYGHAVLRKTDPRYMA
CCCHHHCCCCHHHHH		53.7917644757
354UbiquitinationPRYMAQRKFAMDHFP
HHHHHHHHHHHHHCC		25.9524961812
367UbiquitinationFPDYELFKLVSSIYE
CCCHHHHHHHHHHHH		61.6817644757
385UbiquitinationGVLTEHGKTKNPWPN
CCCCCCCCCCCCCCC		59.2322817900
387UbiquitinationLTEHGKTKNPWPNVD
CCCCCCCCCCCCCCC		65.5824961812
407UbiquitinationLLQYYGLKESSFYTV
CHHHHCCCCHHHHHH		51.7117644757
409PhosphorylationQYYGLKESSFYTVLF
HHHCCCCHHHHHHHH		24.9422369663
410PhosphorylationYYGLKESSFYTVLFG
HHCCCCHHHHHHHHH		24.3022369663
412PhosphorylationGLKESSFYTVLFGVS
CCCCHHHHHHHHHHH		9.6322369663
413PhosphorylationLKESSFYTVLFGVSR
CCCHHHHHHHHHHHH		14.5522369663
419PhosphorylationYTVLFGVSRAFGILA
HHHHHHHHHHHHHHH		20.4722369663
442UbiquitinationGASIERPKSYSTEKY
CCCCCCCCCCCHHHH		69.1417644757
448UbiquitinationPKSYSTEKYKELVKN
CCCCCHHHHHHHHHH		62.8124961812
450UbiquitinationSYSTEKYKELVKNIE
CCCHHHHHHHHHHHH		56.4922817900
454UbiquitinationEKYKELVKNIESKL-
HHHHHHHHHHHHHC-		65.9023749301
459UbiquitinationLVKNIESKL------
HHHHHHHHC------		45.4824961812
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CISY2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CISY2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CISY2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CISY2_YEASTCIT2physical
10688190
MHP1_YEASTMHP1physical
10688190
MDHM_YEASTMDH1physical
10587442
CACM_YEASTYAT1genetic
11329169
YAT2_YEASTYAT2genetic
11329169
CACP_YEASTCAT2genetic
11329169
PROA_YEASTPRO2physical
16554755
RAS1_YEASTRAS1genetic
16832579
CISY2_YEASTCIT2physical
18467557
CISY3_YEASTCIT3genetic
16941010
MDHM_YEASTMDH1genetic
16941010
OAC1_YEASTOAC1genetic
16941010
MCA1_YEASTMCA1genetic
17615299
UBI4P_YEASTUBI4physical
20694217
ODP2_YEASTLAT1genetic
21623372
CRD1_YEASTCRD1genetic
21623372
ODPA_YEASTPDA1genetic
21623372
PDX3_YEASTPDX3genetic
21623372
COX5A_YEASTCOX5Agenetic
21623372
ODPB_YEASTPDB1genetic
21623372
PYC2_YEASTPYC2genetic
21623372
METX_YEASTYML082Wgenetic
21623372
ACON_YEASTACO1genetic
21623372
IDH2_YEASTIDH2genetic
21623372
ADH1_YEASTADH1genetic
21623372
CISY1_YEASTCIT1genetic
21623372
DCOR_YEASTSPE1genetic
21623372
ODPX_YEASTPDX1genetic
21623372
CISY2_YEASTCIT2physical
22615397
CISY3_YEASTCIT3genetic
23416050
PSB6_YEASTPRE7genetic
27708008
LUC7_YEASTLUC7genetic
27708008
ACT_YEASTACT1genetic
27708008
CENPA_YEASTCSE4genetic
27708008
SN114_YEASTSNU114genetic
27708008
UTP15_YEASTUTP15genetic
27708008
MAK5_YEASTMAK5genetic
27708008
MED8_YEASTMED8genetic
27708008
DPOD_YEASTPOL3genetic
27708008
GLE1_YEASTGLE1genetic
27708008
TIM22_YEASTTIM22genetic
27708008
MOB2_YEASTMOB2genetic
27708008
TAF6_YEASTTAF6genetic
27708008
DBF2_YEASTDBF2genetic
27708008
SYMC_YEASTMES1genetic
27708008
MED6_YEASTMED6genetic
27708008
BET1_YEASTBET1genetic
27708008
DPB11_YEASTDPB11genetic
27708008
SDS22_YEASTSDS22genetic
27708008
PRP19_YEASTPRP19genetic
27708008
SED5_YEASTSED5genetic
27708008
MED14_YEASTRGR1genetic
27708008
BOS1_YEASTBOS1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
NBP1_YEASTNBP1genetic
27708008
TAF11_YEASTTAF11genetic
27708008
SEC65_YEASTSEC65genetic
27708008
PGA3_YEASTPGA3genetic
27708008
LST8_YEASTLST8genetic
27708008
OST2_YEASTOST2genetic
27708008
RPC1_YEASTRPO31genetic
27708008
SEC8_YEASTSEC8genetic
27708008
TF2B_YEASTSUA7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CISY2_YEAST

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Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-354 AND LYS-385, AND MASSSPECTROMETRY.

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