METX_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: METX_YEAST
• UniProt AC: Q04533
• Protein Name: Putative cystathionine gamma-synthase YML082W
• Gene Name: YML082W
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 649
• Protein Description: Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity)..
• Protein Sequence: MVSAQVATELGQPIPLDTQHAVSVCFPTWKSVISYVEKDPKVLGCLKSGYPRFWIHPSIQKLRDILIEKYAKENETCFCFPSYRVAKRCREYVRRKCAHRNGKVRILQLATAKPINEEQKTWKRECKIAVVFVDGAYENILKQYWQYTGEIISSRLAEYVLHELFMVEKKSSPAEEKEYIEMRYGRNLNFAFADRAKELIKKRIATKVIDKDEHDEEENYHFLAGNQDEQDFQDTFLDSSLNEANHGEDHDGGISGEVDSQEEPHNGLVSTIPPEPIEMSTIEEEQSVEEDAGRCALRVCPERDVFLFPSGMASIFTAHRLLLQWDSLRLNRSRNGSDVTSSPPNKKTVIFGFPYADTLHVLQEFNETYFLGEGDESSMKELTKILHSGEQILAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPFADIVCSSLTKTFSGDSNVIGGSMVLNPQSRVYEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFIARTIRINYSTEYLLDKILKPHVGENKLFKKIYYPNLTSKETLTNYDMVRCKKEGGYGGLFSLTFHDEDHAAAFYDNLKLNKGPSLGTNFTLAFPYTLMTYYHELDMAEKFGVERNLLRISVGLESQSILGKIFQEAIDKTVEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	VCFPTWKSVISYVEK EECCCHHHHHHHHHC	19.08	28889911
38	Acetylation	SVISYVEKDPKVLGC HHHHHHHCCCCHHCH	70.10	24489116
171	Phosphorylation	LFMVEKKSSPAEEKE HHHHCCCCCCHHHHH	53.26	19779198
287	Phosphorylation	STIEEEQSVEEDAGR CCCCCHHCHHHHHCC	34.47	28889911
340	Phosphorylation	SRNGSDVTSSPPNKK CCCCCCCCCCCCCCC	28.60	28889911
341	Phosphorylation	RNGSDVTSSPPNKKT CCCCCCCCCCCCCCE	40.47	25315811
342	Phosphorylation	NGSDVTSSPPNKKTV CCCCCCCCCCCCCEE	34.70	28889911
451	N6-(pyridoxal phosphate)lysine	IVCSSLTKTFSGDSN HHHHCCCEECCCCCC	53.52	-
451	Other	IVCSSLTKTFSGDSN HHHHCCCEECCCCCC	53.52	-
562	Phosphorylation	RCKKEGGYGGLFSLT EEEECCCCCCEEEEE	20.91	24930733
567	Phosphorylation	GGYGGLFSLTFHDED CCCCCEEEEEECCCC	31.38	24930733
569	Phosphorylation	YGGLFSLTFHDEDHA CCCEEEEEECCCCCH	20.09	24930733
631	Phosphorylation	RISVGLESQSILGKI EEEECCCHHHHHHHH	33.98	27017623
633	Phosphorylation	SVGLESQSILGKIFQ EECCCHHHHHHHHHH	29.12	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of METX_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of METX_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of METX_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MET30_YEAST	MET30	physical	18719252
MED6_YEAST	MED6	genetic	27708008
FIP1_YEAST	FIP1	genetic	27708008
NEP1_YEAST	EMG1	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
NOP2_YEAST	NOP2	genetic	27708008
DCP2_YEAST	DCP2	genetic	27708008
TYSY_YEAST	CDC21	genetic	27708008
CHK1_YEAST	CHK1	genetic	27708008
RLA1_YEAST	RPP1A	genetic	27708008
YP089_YEAST	YPR089W	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287, AND MASSSPECTROMETRY.
PubMed: 18407956