| UniProt ID | NOP2_YEAST | |
|---|---|---|
| UniProt AC | P40991 | |
| Protein Name | 25S rRNA (cytosine(2870)-C(5))-methyltransferase | |
| Gene Name | NOP2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 618 | |
| Subcellular Localization | Nucleus, nucleolus. | |
| Protein Description | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA. Required for 60S ribosomal subunit synthesis and processing.. | |
| Protein Sequence | MGSRRHKNKQAAPPTLEEFQARKEKKANRKLEKGKRPSTTQGDEVSDRKKKKSKPFKKSRKEEEEVVEEDKDLPEVDLEELSKARKSLFDDEEDDDEAGLVDEELKDEFDLEQEYDYDEDEDNDAHPIFSDDDDEADLEELNAQNMEALSKKLDEEEAEEAEEAEMELVEAENMQPRADILPTEEQEEMMAQETPNLTSTRTRMIEIVKVLENFKTLGAEGRSRGEYVDRLLKDICEYFGYTPFLAEKLFNLFSPAEAMEFFEANEIARPITIRTNTLKTRRRDLAQTLVNRGVNLQPIGSWTKVGLQIFDSQVPIGATPEYLAGHYILQAASSFLPVIALDPHENERILDMAAAPGGKTTYISAMMKNTGCVFANDANKSRTKSLIANIHRLGCTNTIVCNYDAREFPKVIGGFDRILLDAPCSGTGVIGKDQSVKVSRTEKDFIQIPHLQKQLLLSAIDSVDCNSKHGGVIVYSTCSVAVEEDEAVIDYALRKRPNVKLVDTGLAIGKEAFTSYRGKKFHPSVKLARRYYPHTYNVDGFFVAKFQKIGPSSFDDNQASAKEKETAARKEALEEGIIHSDFATFEDEEDDKYIEKSVKNNLLKKGVNPKAKRPSNEK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 23 | Ubiquitination | LEEFQARKEKKANRK HHHHHHHHHHHHHHH | 76.52 | 17644757 | |
| 25 | Ubiquitination | EFQARKEKKANRKLE HHHHHHHHHHHHHHH | 61.29 | 17644757 | |
| 26 | Ubiquitination | FQARKEKKANRKLEK HHHHHHHHHHHHHHC | 52.57 | 17644757 | |
| 30 | Ubiquitination | KEKKANRKLEKGKRP HHHHHHHHHHCCCCC | 61.89 | 17644757 | |
| 35 | Acetylation | NRKLEKGKRPSTTQG HHHHHCCCCCCCCCC | 72.68 | 22865919 | |
| 38 | Phosphorylation | LEKGKRPSTTQGDEV HHCCCCCCCCCCCCC | 48.39 | 23749301 | |
| 40 | Phosphorylation | KGKRPSTTQGDEVSD CCCCCCCCCCCCCCH | 34.59 | 28889911 | |
| 46 | Phosphorylation | TTQGDEVSDRKKKKS CCCCCCCCHHHHHCC | 29.65 | 27717283 | |
| 71 | Acetylation | EEVVEEDKDLPEVDL HHHHHHCCCCCCCCH | 65.53 | 24489116 | |
| 83 | Acetylation | VDLEELSKARKSLFD CCHHHHHHHHHHHCC | 65.91 | 24489116 | |
| 183 | Phosphorylation | PRADILPTEEQEEMM CCCCCCCHHHHHHHH | 49.02 | 21126336 | |
| 194 | Phosphorylation | EEMMAQETPNLTSTR HHHHCCCCCCCCCHH | 12.85 | 25752575 | |
| 215 | Ubiquitination | VKVLENFKTLGAEGR HHHHHHHHCCCCCCC | 55.19 | 23749301 | |
| 215 | Acetylation | VKVLENFKTLGAEGR HHHHHHHHCCCCCCC | 55.19 | 24489116 | |
| 288 | Phosphorylation | RRRDLAQTLVNRGVN HHHHHHHHHHHCCCC | 27.37 | 27017623 | |
| 301 | Phosphorylation | VNLQPIGSWTKVGLQ CCCCCCCCEEEEEEE | 32.09 | 30377154 | |
| 380 | Ubiquitination | VFANDANKSRTKSLI EECCCCCHHHHHHHH | 42.93 | 23749301 | |
| 385 | Phosphorylation | ANKSRTKSLIANIHR CCHHHHHHHHHHHHH | 25.13 | 21440633 | |
| 439 | Phosphorylation | KDQSVKVSRTEKDFI CCCCEEEECCCCCHH | 27.97 | 19823750 | |
| 441 | Phosphorylation | QSVKVSRTEKDFIQI CCEEEECCCCCHHCC | 39.62 | 19823750 | |
| 443 | Acetylation | VKVSRTEKDFIQIPH EEEECCCCCHHCCHH | 58.27 | 24489116 | |
| 510 | Ubiquitination | DTGLAIGKEAFTSYR ECCCCCCHHHHHCCC | 39.49 | 23749301 | |
| 548 | Ubiquitination | FFVAKFQKIGPSSFD EEEEEECCCCCCCCC | 53.41 | 23749301 | |
| 580 | Phosphorylation | LEEGIIHSDFATFED HHHCCCCCCCCCCCC | 24.82 | 25521595 | |
| 584 | Phosphorylation | IIHSDFATFEDEEDD CCCCCCCCCCCCCCH | 27.79 | 26447709 | |
| 593 | Phosphorylation | EDEEDDKYIEKSVKN CCCCCHHHHHHHHHH | 22.70 | 29688323 | |
| 599 | Acetylation | KYIEKSVKNNLLKKG HHHHHHHHHCHHHCC | 47.40 | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NOP2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NOP2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NOP2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-580, AND MASSSPECTROMETRY. | |
