RL43A_YEAST - dbPTM
RL43A_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RL43A_YEAST
UniProt AC P0CX25
Protein Name 60S ribosomal protein L43-A {ECO:0000303|PubMed:9559554}
Gene Name RPL43A {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 92
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MAKRTKKVGITGKYGVRYGSSLRRQVKKLEIQQHARYDCSFCGKKTVKRGAAGIWTCSCCKKTVAGGAYTVSTAAAATVRSTIRRLREMVEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13AcetylationKKVGITGKYGVRYGS
CCEECCCCHHHCCCH		30.1324489116
18PhosphorylationTGKYGVRYGSSLRRQ
CCCHHHCCCHHHHHH		20.9619779198
20PhosphorylationKYGVRYGSSLRRQVK
CHHHCCCHHHHHHHH		19.7721440633
21PhosphorylationYGVRYGSSLRRQVKK
HHHCCCHHHHHHHHH		22.8717287358
28AcetylationSLRRQVKKLEIQQHA
HHHHHHHHHHHHHHH		53.1224489116
40PhosphorylationQHARYDCSFCGKKTV
HHHCCCCCCCCCCCC		22.2217287358
44AcetylationYDCSFCGKKTVKRGA
CCCCCCCCCCCCCCC		46.5925381059
44UbiquitinationYDCSFCGKKTVKRGA
CCCCCCCCCCCCCCC		46.59-
56PhosphorylationRGAAGIWTCSCCKKT
CCCCEEEEECCCCCC		7.8227017623
58PhosphorylationAAGIWTCSCCKKTVA
CCEEEEECCCCCCCC		18.3827017623
61UbiquitinationIWTCSCCKKTVAGGA
EEEECCCCCCCCCCC		56.67-
62UbiquitinationWTCSCCKKTVAGGAY
EEECCCCCCCCCCCE		34.03-
70PhosphorylationTVAGGAYTVSTAAAA
CCCCCCEEHHHHHHH		13.8817287358
73PhosphorylationGGAYTVSTAAAATVR
CCCEEHHHHHHHHHH		18.9128152593
81PhosphorylationAAAATVRSTIRRLRE
HHHHHHHHHHHHHHH		24.6917287358
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RL43A_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RL43A_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RL43A_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SYEC_YEASTGUS1physical
16554755
GCN4_YEASTGCN4genetic
18423200
SIR2_YEASTSIR2genetic
21902802
MCM1_YEASTMCM1genetic
27708008
INO4_YEASTINO4genetic
27708008
TECR_YEASTTSC13genetic
27708008
CDC13_YEASTCDC13genetic
27708008
UBC3_YEASTCDC34genetic
27708008
EXO70_YEASTEXO70genetic
27708008
CDC6_YEASTCDC6genetic
27708008
PRS7_YEASTRPT1genetic
27708008
PSA7_YEASTPRE10genetic
27708008
PAT1_YEASTPAT1genetic
27708008
STP1_YEASTSTP1genetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
XRN1_YEASTXRN1genetic
27708008
ATG1_YEASTATG1genetic
27708008
YOR1_YEASTYOR1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
STB5_YEASTSTB5genetic
27708008
DAL81_YEASTDAL81genetic
27708008
PEP8_YEASTPEP8genetic
27708008
LSM1_YEASTLSM1genetic
27708008
MRT4_YEASTMRT4genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
SIC1_YEASTSIC1genetic
27708008
ERG6_YEASTERG6genetic
27708008
GBLP_YEASTASC1genetic
27708008
RTG1_YEASTRTG1genetic
27708008
THP3_YEASTTHP3genetic
27708008
NAA30_YEASTMAK3genetic
27708008
PUF6_YEASTPUF6physical
27458021
LOC1_YEASTLOC1physical
27458021
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RL43A_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-40; THR-70 ANDSER-81, AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory