THP3_YEAST - dbPTM
THP3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THP3_YEAST
UniProt AC Q12049
Protein Name Protein THP3
Gene Name THP3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 470
Subcellular Localization Nucleus .
Protein Description Forms a complex with CSN12 that is recruited to transcribed genes and required for transcription elongation. May also be involved in pre-mRNA splicing..
Protein Sequence MQNPYGHFTNNTTEDREASSQGGPFGQSLNRPLDYAGSFPSLTYNNNNFIANQQPSLPLPEPRLSWNNVNQVSNPLMVTPLPGLQKRMNKNIKKKLPRVSKKASALSNGVSGNVMSNSNIVGHGAVGSASGWKVEMGGSDELERRKRRAERFSQGPSATTNSNDNLNEDFANLNAISSKSHQYDKKIHVVGRCQTLEKSYLRLTSEPNPDLIRPPNILQKMYCLLMDKYQSKTATYTYLCDQFKSMRQDLRVQMIENSFTIKVYQTHARIALENGDLGEFNQCQNRIMALFENPTIPKKSYSEFICYSVLYSMLTEDYPSISHLKLKLIDDGSSEILEDEHVKMIFELSDMKLVGNYHYFMKNYLKLHKFEKCLINSFLNLEKLIFLTIICKSYNQVNLDFVKSEFNFNSIEETTNFLNEQNLTEFILNKQITDSNGKSSNIKILNTKGCRVQLIQNYMKSKKIDIKGQK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MQNPYGHF
-------CCCCCCCC		8.6222814378
5Phosphorylation---MQNPYGHFTNNT
---CCCCCCCCCCCC		30.6828889911
9PhosphorylationQNPYGHFTNNTTEDR
CCCCCCCCCCCCCCH		23.1428889911
12PhosphorylationYGHFTNNTTEDREAS
CCCCCCCCCCCHHHH		33.3628889911
13PhosphorylationGHFTNNTTEDREASS
CCCCCCCCCCHHHHH		37.7028889911
73PhosphorylationWNNVNQVSNPLMVTP
CCCCCCCCCCCCCCC		23.9830377154
139PhosphorylationWKVEMGGSDELERRK
CEEECCCCHHHHHHH		23.3730377154
153PhosphorylationKRRAERFSQGPSATT
HHHHHHHHCCCCCCC		40.2122369663
157PhosphorylationERFSQGPSATTNSND
HHHHCCCCCCCCCCC		45.1022369663
159PhosphorylationFSQGPSATTNSNDNL
HHCCCCCCCCCCCCC		30.7422369663
160PhosphorylationSQGPSATTNSNDNLN
HCCCCCCCCCCCCCC		36.0422369663
162PhosphorylationGPSATTNSNDNLNED
CCCCCCCCCCCCCHH		43.3922369663
177PhosphorylationFANLNAISSKSHQYD
HHHHHHHHCCCCCCC		29.3322369663
178PhosphorylationANLNAISSKSHQYDK
HHHHHHHCCCCCCCC		31.8722369663
199PhosphorylationRCQTLEKSYLRLTSE
ECCCCCHHHHHHCCC		21.7430377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THP3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THP3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THP3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SLX5_YEASTSLX5physical
16554755
SWA2_YEASTSWA2physical
16554755
SEM1_YEASTSEM1physical
16554755
YRA1_YEASTYRA1physical
16554755
LOC1_YEASTLOC1physical
16554755
EBP2_YEASTEBP2physical
16554755
RPF2_YEASTRPF2physical
16554755
RRS1_YEASTRRS1physical
16554755
SEM1_YEASTSEM1physical
19061648
RRP7_YEASTRRP7genetic
19061648
FBRL_YEASTNOP1genetic
19061648
PABP_YEASTPAB1genetic
19061648
YPT6_YEASTYPT6genetic
19061648
NMD5_YEASTNMD5genetic
19061648
SSB2_YEASTSSB2physical
19536198
HSP7F_YEASTSSE1physical
19536198
EDE1_YEASTEDE1genetic
20093466
HAP3_YEASTHAP3genetic
20093466
ATG14_YEASTATG14genetic
20093466
BUD31_YEASTBUD31genetic
20093466
ATIF_YEASTINH1genetic
20093466
RS16A_YEASTRPS16Bgenetic
20093466
RS16B_YEASTRPS16Bgenetic
20093466
NBP2_YEASTNBP2genetic
20093466
PMP3_YEASTPMP3genetic
20093466
BEM2_YEASTBEM2genetic
20093466
VAM7_YEASTVAM7genetic
20093466
CWC26_YEASTBUD13genetic
20093466
LEUC_YEASTLEU1genetic
20093466
SERB_YEASTSER2genetic
20093466
COPE_YEASTSEC28genetic
20093466
IST3_YEASTIST3genetic
20093466
GYP6_YEASTGYP6genetic
20093466
ELM1_YEASTELM1genetic
20093466
VPS24_YEASTVPS24genetic
20093466
SIC1_YEASTSIC1genetic
20093466
NU188_YEASTNUP188genetic
20093466
SCS7_YEASTSCS7genetic
20093466
EOS1_YEASTEOS1genetic
20093466
MKS1_YEASTMKS1genetic
20093466
ATG3_YEASTATG3genetic
20093466
MED9_YEASTCSE2genetic
20093466
DGK1_YEASTDGK1genetic
20093466
MNE1_YEASTMNE1genetic
20093466
RU2A_YEASTLEA1genetic
20093466
CSN12_YEASTYJR084Wphysical
21149575
CLP1_YEASTCLP1genetic
27708008
ELO2_YEASTELO2genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
AAR2_YEASTAAR2genetic
27708008
TECR_YEASTTSC13genetic
27708008
PRP11_YEASTPRP11genetic
27708008
PDC2_YEASTPDC2genetic
27708008
SLU7_YEASTSLU7genetic
27708008
CDC1_YEASTCDC1genetic
27708008
SYF1_YEASTSYF1genetic
27708008
GNA1_YEASTGNA1genetic
27708008
PRP43_YEASTPRP43genetic
27708008
SWC4_YEASTSWC4genetic
27708008
PRP18_YEASTPRP18genetic
27708008
SMD1_YEASTSMD1genetic
27708008
NUP57_YEASTNUP57genetic
27708008
RRP4_YEASTRRP4genetic
27708008
PRP19_YEASTPRP19genetic
27708008
CLF1_YEASTCLF1genetic
27708008
ERO1_YEASTERO1genetic
27708008
CEF1_YEASTCEF1genetic
27708008
DBP6_YEASTDBP6genetic
27708008
TPT1_YEASTTPT1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
BDF2_YEASTBDF2genetic
27708008
ATIF_YEASTINH1genetic
27708008
CWC26_YEASTBUD13genetic
27708008
MED20_YEASTSRB2genetic
27708008
IST3_YEASTIST3genetic
27708008
ISY1_YEASTISY1genetic
27708008
VPS24_YEASTVPS24genetic
27708008
TMA23_YEASTTMA23genetic
27708008
SCS7_YEASTSCS7genetic
27708008
EOS1_YEASTEOS1genetic
27708008
PHO23_YEASTPHO23genetic
27708008
ATG3_YEASTATG3genetic
27708008
RTG1_YEASTRTG1genetic
27708008
GDS1_YEASTGDS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THP3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162, AND MASSSPECTROMETRY.

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