GYP6_YEAST - dbPTM
GYP6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GYP6_YEAST
UniProt AC P32806
Protein Name GTPase-activating protein GYP6
Gene Name GYP6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 458
Subcellular Localization Cytoplasm .
Protein Description Stimulates specifically the GTPase activity of YPT6..
Protein Sequence MKDVLQWAIDHYETRDQLVQKGIWKGELYHDSIFKENSRGWLWKALLLCDENNNCLLTDNFKGLDLNQFGLVPVPMLADGDNYDENHNANVPKRVLHSNVSSSVGIRRLTPVEAVEKHPLSDDNDKTKGSLSKGSDEKPLTLRETLEIIDLDLSRIMLDDIFQEPKVHAQMRQLLYNYLLIHQSEHLQYKQGFHEILSVIYLQLYHGTDLDNTDLQNVLIIFNKLMNQIEPIFYNEENLINWDKRVFTKIFRICLPDLFSKVFYQPPKTGSGKKKNVDHLIHSNLIWLIRWTRLLFLRELPLKYVLIVWDHVLTFNYPLDIFIACTIITLLLSIYDELHELVSQGDYEHTNNNDEFVELILHFKKIFEKEDASKDDEKFLDLCKVTGNLCELWYGKNYDDMRLICDTFINAKFGIKTSDVLSMETAKLTIDPNRQSLENKLRERVRQTILKNKKKISQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
102PhosphorylationVLHSNVSSSVGIRRL
HHCCCCCCCCCCCCC		25.4323749301
103PhosphorylationLHSNVSSSVGIRRLT
HCCCCCCCCCCCCCC		19.5024961812
110PhosphorylationSVGIRRLTPVEAVEK
CCCCCCCCCCCHHHH		24.3922369663
121PhosphorylationAVEKHPLSDDNDKTK
HHHHCCCCCCCCCCC		47.5828889911
249AcetylationWDKRVFTKIFRICLP
CCHHHHHHHHHHHCH		28.5124489116
417PhosphorylationNAKFGIKTSDVLSME
HHCCCCCHHHCCCHH		28.3927017623
418PhosphorylationAKFGIKTSDVLSMET
HCCCCCHHHCCCHHE		22.2527017623
429PhosphorylationSMETAKLTIDPNRQS
CHHEEEEEECCCHHH		23.7227017623
436PhosphorylationTIDPNRQSLENKLRE
EECCCHHHHHHHHHH		34.1225005228
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GYP6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GYP6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GYP6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TR120_YEASTTRS120physical
11805837
TR130_YEASTTRS130physical
11805837
NHX1_YEASTNHX1physical
14610088
YPT6_YEASTYPT6physical
8441469
RRP1_YEASTRRP1physical
16554755
LSM12_YEASTLSM12physical
16554755
CSK21_YEASTCKA1physical
16554755
NAP1_YEASTNAP1physical
16554755
BET3_YEASTBET3physical
16554755
STM1_YEASTSTM1physical
16554755
UIP3_YEASTUIP3genetic
20093466
PRX1_YEASTPRX1genetic
20093466
OLA1_YEASTOLA1genetic
20093466
TPS1_YEASTTPS1genetic
20093466
YPQ3_YEASTRTC2genetic
20093466
AMN1_YEASTAMN1genetic
20093466
MGR1_YEASTMGR1genetic
20093466
S2538_YEASTYDL119Cgenetic
20093466
NHP10_YEASTNHP10genetic
20093466
UBC13_YEASTUBC13genetic
20093466
SPO71_YEASTSPO71genetic
20093466
OMS1_YEASTOMS1genetic
20093466
EAF1_YEASTEAF1genetic
20093466
RV167_YEASTRVS167genetic
20093466
SPT3_YEASTSPT3genetic
20093466
KRE28_YEASTKRE28genetic
20093466
SERA_YEASTSER3genetic
20093466
DDI1_YEASTDDI1genetic
20093466
PT122_YEASTPET122genetic
20093466
BUD27_YEASTBUD27genetic
20093466
IES1_YEASTIES1genetic
20093466
RTF1_YEASTRTF1genetic
20093466
VAM7_YEASTVAM7genetic
20093466
YG1T_YEASTYGR042Wgenetic
20093466
YG34_YEASTYGR122Wgenetic
20093466
YG5B_YEASTYGR250Cgenetic
20093466
SLH1_YEASTSLH1genetic
20093466
YHJ3_YEASTYHR033Wgenetic
20093466
LRP1_YEASTLRP1genetic
20093466
CSK21_YEASTCKA1genetic
20093466
DOT5_YEASTDOT5genetic
20093466
PSMD9_YEASTNAS2genetic
20093466
CBT1_YEASTCBT1genetic
20093466
TPO5_YEASTTPO5genetic
20093466
NNK1_YEASTNNK1genetic
20093466
CYT2_YEASTCYT2genetic
20093466
MUD2_YEASTMUD2genetic
20093466
FRMSR_YEASTYKL069Wgenetic
20093466
VPS51_YEASTVPS51genetic
20093466
GTO2_YEASTECM4genetic
20093466
COX12_YEASTCOX12genetic
20093466
VRP1_YEASTVRP1genetic
20093466
RSC2_YEASTRSC2genetic
20093466
MGR3_YEASTMGR3genetic
20093466
YM39_YEASTYMR166Cgenetic
20093466
YM79_YEASTYMR244Wgenetic
20093466
LSM7_YEASTLSM7genetic
20093466
SWS2_YEASTSWS2genetic
20093466
VPS27_YEASTVPS27genetic
20093466
PP2A4_YEASTPPG1genetic
20093466
COQ2_YEASTCOQ2genetic
20093466
IRA2_YEASTIRA2genetic
20093466
YO08A_YEASTYOR008C-Agenetic
20093466
NAT5_YEASTNAT5genetic
20093466
PALA_YEASTRIM20genetic
20093466
BECN1_YEASTVPS30genetic
20093466
GGPPS_YEASTBTS1genetic
20093466
SUR1_YEASTSUR1genetic
20093466
NACB1_YEASTEGD1genetic
20093466
RAD1_YEASTRAD1genetic
20093466
YP011_YEASTYPR011Cgenetic
20093466
THP3_YEASTTHP3genetic
20093466
JID1_YEASTJID1genetic
20093466
MED1_YEASTMED1genetic
20093466
YNU8_YEASTYNL208Wgenetic
20526336
SYS1_YEASTSYS1genetic
20526336
CMR1_YEASTCMR1genetic
22842922
GAS1_YEASTGAS1genetic
23891562
GOSR1_YEASTGOS1genetic
23891562
CSG2_YEASTCSG2genetic
23891562
BPH1_YEASTBPH1genetic
23891562
GYP1_YEASTGYP1genetic
24924636
GYP8_YEASTGYP8genetic
24924636
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GYP6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-110 AND SER-436, ANDMASS SPECTROMETRY.

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