dbPTM

UIP3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UIP3_YEAST
UniProt AC	P39547
Protein Name	ULP1-interacting protein 3
Gene Name	UIP3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	235
Subcellular Localization	Nucleus membrane Multi-pass membrane protein . Cell membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MQTPSENTDVKLDTLDEPSAHLIEENVALPEDTFNSYWSYILNEIARCKPLMIMFLIPVCLVLLITFFHDIKGILVFLVISLILSIIILLIGITAFVSETLNKGFIIKLLVEVITRKPAVGGKEWRIIAYNMNQYLFDHGIWHTPYYFFCEHRCHKFFKSLIKQTRSNAHLSSPTNGAENTQSNTPAKEVSNEMVKPYIFSSDPVLEAYLIKAAEIHKEAEFEYWRKQYPEVDLP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MQTPSENTDV -----CCCCCCCCCC	27.73	25752575
5	Phosphorylation	---MQTPSENTDVKL ---CCCCCCCCCCCC	47.03	28889911
8	Phosphorylation	MQTPSENTDVKLDTL CCCCCCCCCCCCCCC	37.81	27717283
11	Ubiquitination	PSENTDVKLDTLDEP CCCCCCCCCCCCCCC	43.38	12872131
167	Phosphorylation	SLIKQTRSNAHLSSP HHHHHHHHCCCCCCC	41.58	21440633
173	Phosphorylation	RSNAHLSSPTNGAEN HHCCCCCCCCCCCCC	41.95	23749301
188	Ubiquitination	TQSNTPAKEVSNEMV CCCCCCHHHHCHHHC	60.91	24961812
218	Ubiquitination	IKAAEIHKEAEFEYW HHHHHHHHHHHHHHH	65.37	23749301
227	Ubiquitination	AEFEYWRKQYPEVDL HHHHHHHHHCCCCCC	39.78	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UIP3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UIP3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UIP3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UIP3_YEAST	UIP3	physical	18719252
PMT2_YEAST	PMT2	physical	16093310
PHO88_YEAST	PHO88	physical	16093310
MKAR_YEAST	IFA38	physical	16093310
GEX1_YEAST	GEX1	physical	16093310
GGC1_YEAST	GGC1	physical	16093310
PDR15_YEAST	PDR15	physical	16093310
YEF1_YEAST	YEF1	physical	16093310
RT23_YEAST	RSM23	physical	16093310
MSB2_YEAST	MSB2	physical	16093310
ERV29_YEAST	ERV29	physical	16093310
YHK8_YEAST	YHK8	physical	16093310
BET1_YEAST	BET1	physical	16093310
SNL1_YEAST	SNL1	physical	16093310
COX5B_YEAST	COX5B	physical	16093310
MGA2_YEAST	MGA2	physical	16093310
OST1_YEAST	OST1	physical	16093310
TOK1_YEAST	TOK1	physical	16093310
GEF1_YEAST	GEF1	physical	16093310
YKT6_YEAST	YKT6	physical	16093310
VBA5_YEAST	VBA5	physical	16093310
U5072_YEAST	YML002W	physical	16093310
YMD8_YEAST	YMD8	physical	16093310
OSTD_YEAST	SWP1	physical	16093310
CUE1_YEAST	CUE1	physical	16093310
YM8M_YEAST	YMR279C	physical	16093310
ESBP6_YEAST	ESBP6	physical	16093310
GAS5_YEAST	GAS5	physical	16093310
HXT11_YEAST	HXT11	physical	16093310
TPO4_YEAST	TPO4	physical	16093310
SEC62_YEAST	SEC62	physical	16093310
ANT1_YEAST	ANT1	physical	16093310
UIP3_YEAST	UIP3	physical	16093310
HSP71_YEAST	SSA1	physical	22940862
TR130_YEAST	TRS130	genetic	23891562
MKK2_YEAST	MKK2	genetic	23891562
COAD_YEAST	CAB4	genetic	27708008
DPOA2_YEAST	POL12	genetic	27708008
TAF6_YEAST	TAF6	genetic	27708008
PRP18_YEAST	PRP18	genetic	27708008
ORC6_YEAST	ORC6	genetic	27708008
CYAA_YEAST	CYR1	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
POB3_YEAST	POB3	genetic	27708008
MCM1_YEAST	MCM1	genetic	27708008
SEC23_YEAST	SEC23	genetic	27708008
TMM79_HUMAN	TMEM79	physical	27107014

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UIP3_YEAST

Related Literatures of Post-Translational Modification

Ubiquitylation
Reference	PubMed
"A proteomics approach to understanding protein ubiquitination."; Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.; Nat. Biotechnol. 21:921-926(2003). Cited for: PROTEIN SEQUENCE OF 1-21 AND 213-226, MASS SPECTROMETRY, ANDUBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-11 AND LYS-218.	12872131 [Abstract]