MKK2_YEAST - dbPTM
MKK2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MKK2_YEAST
UniProt AC P32491
Protein Name MAP kinase kinase MKK2/SSP33
Gene Name MKK2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 506
Subcellular Localization
Protein Description Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involves the kinase PKC1 that may act on the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase..
Protein Sequence MASMFRPPESNRSHQKTPKLTLPVNLVQNAKSTNDGQHLNRSPYSSVNESPYSNNSTSATSTTSSMASNSTLLYNRSSTTTIKNRPVPPPLPPLVLTQKKDGIEYRVAGDSQLSERFSNLHVDITYKELLSSAPISTKLSNIDTTFIKKDLDTPEGEDSYPSTLLSAYDFSSSGSNSAPLSANNIISCSNLIQGKDVDQLEEEAWRFGHLKDEITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLKHPWIVGQMKKKVNMERFVKKCWEKEKDGI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
50PhosphorylationPYSSVNESPYSNNST
CCCCCCCCCCCCCCC		24.7617711850
131PhosphorylationITYKELLSSAPISTK
EEHHHHHHCCCCCHH		36.7624961812
132PhosphorylationTYKELLSSAPISTKL
EHHHHHHCCCCCHHC		37.7324961812
136PhosphorylationLLSSAPISTKLSNID
HHHCCCCCHHCCCCC		20.5924961812
137PhosphorylationLSSAPISTKLSNIDT
HHCCCCCHHCCCCCC		36.4024961812
162PhosphorylationEGEDSYPSTLLSAYD
CCCCCCCHHHEEEEC		24.3728889911
215PhosphorylationGHLKDEITTLGILGE
HCHHHHHEEEEECCC		17.5828889911
216PhosphorylationHLKDEITTLGILGEG
CHHHHHEEEEECCCC		28.7528889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
50SPhosphorylationKinaseSLT2Q00772
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MKK2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MKK2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BCK1_YEASTBCK1physical
11805837
RNQ1_YEASTRNQ1physical
11805837
BUL1_YEASTBUL1physical
11805837
RUVB1_YEASTRVB1physical
11805837
RGD1_YEASTRGD1physical
11805837
GPN1_YEASTNPA3physical
11805837
PRTB_YEASTPRB1physical
11805837
RPN1_YEASTRPN1physical
11805837
IDH1_YEASTIDH1physical
11805837
RPN7_YEASTRPN7physical
11805837
ARP2_YEASTARP2physical
11805837
LYS12_YEASTLYS12physical
11805837
SLT2_YEASTSLT2physical
8757399
SLT2_YEASTSLT2physical
8596433
YP109_YEASTYPL109Cgenetic
19269370
PLC1_YEASTPLC1genetic
19269370
CSG2_YEASTCSG2genetic
20093466
TPS1_YEASTTPS1genetic
20093466
DOT1_YEASTDOT1genetic
20093466
ZRT1_YEASTZRT1genetic
20093466
IRE1_YEASTIRE1genetic
20093466
ASF1_YEASTASF1genetic
20093466
RL22A_YEASTRPL22Agenetic
20093466
COX7_YEASTCOX7genetic
20093466
MKK1_YEASTMKK1genetic
20093466
BCK1_YEASTBCK1physical
20489023
DBP5_YEASTDBP5physical
20489023
EI2BE_YEASTGCD6physical
20489023
GCN1_YEASTGCN1physical
20489023
HRP1_YEASTHRP1physical
20489023
PBP4_YEASTPBP4physical
20489023
PFKA1_YEASTPFK1physical
20489023
RGD1_YEASTRGD1physical
20489023
RNQ1_YEASTRNQ1physical
20489023
RV161_YEASTRVS161physical
20489023
RV167_YEASTRVS167physical
20489023
METK1_YEASTSAM1physical
20489023
PER1_YEASTPER1genetic
20526336
FUS3_YEASTFUS3genetic
21127252
DAL82_YEASTDAL82genetic
21127252
MET18_YEASTMET18genetic
21127252
MKK1_YEASTMKK1genetic
21127252
SIP3_YEASTSIP3genetic
21127252
CTK3_YEASTCTK3genetic
21127252
FAB1_YEASTFAB1genetic
21127252
RTG3_YEASTRTG3genetic
21127252
VMS1_YEASTVMS1genetic
21127252
KCS1_YEASTKCS1genetic
21127252
MKK1_YEASTMKK1genetic
14573466
ZRT1_YEASTZRT1genetic
22282571
DOT1_YEASTDOT1genetic
22282571
MKK1_YEASTMKK1genetic
22282571
COX7_YEASTCOX7genetic
22282571
IRE1_YEASTIRE1genetic
22282571
TPS1_YEASTTPS1genetic
22282571
ASF1_YEASTASF1genetic
22282571
RL22A_YEASTRPL22Agenetic
22282571
CSG2_YEASTCSG2genetic
22282571
DHE2_YEASTGDH2genetic
27708008
PNPP_YEASTPHO13genetic
27708008
TPS2_YEASTTPS2genetic
27708008
YD124_YEASTYDR124Wgenetic
27708008
CWC15_YEASTCWC15genetic
27708008
TRM82_YEASTTRM82genetic
27708008
UME6_YEASTUME6genetic
27708008
RTN1_YEASTRTN1genetic
27708008
CYPD_YEASTCPR5genetic
27708008
DOT1_YEASTDOT1genetic
27708008
IRE1_YEASTIRE1genetic
27708008
COX7_YEASTCOX7genetic
27708008
DIA2_YEASTDIA2genetic
27708008
MKK1_YEASTMKK1genetic
27708008
SLT2_YEASTSLT2genetic
27413009
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MKK2_YEAST

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Related Literatures of Post-Translational Modification

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