SIP3_YEAST - dbPTM
SIP3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SIP3_YEAST
UniProt AC P38717
Protein Name Membrane-anchored lipid-binding protein SIP3 {ECO:0000303|PubMed:26001273}
Gene Name SIP3 {ECO:0000303|PubMed:8127709}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1229
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein . Localizes to puncta in the cell periphery representing cortical endoplasmic reticulum (cER)-plasma membrane (PM) membrane contact sites.
Protein Description May be involved in sterol transfer between intracellular membranes..
Protein Sequence MSVHGRDPKKRQLRLISVAFKEASIDSPSFRASVNFFQTRVDALEDWIEKTVDFFDQKYKVSFEDFRRAKETLLSQLLPPPALLSNGFVSNQSFTPRLIDSFNKDYYDFSMKLLQIVKGDDSSHSTALLELMTTAIEPYRNVRKNFDFYQGKYDSMLASYQAIRISKTSLEPSSIKSDALQLFEVQKNYLKASLDLISAISAVKLSLDKFILESMKVLKSRSIFITKDSGRKIDLSPCINEYLDNYAIWVENSIEGSKVLDSDISNAKKQAYRYTLKRITPSSDTSDYNIRSIHSSKLLSKDTQVPPKSPEKSGWLYMKTQVGKPTREIWVRRWCFLKNAVFGMFLLSPSKTYVEETDKFGVFLTNVRYDPEEDRKFCFEVKIFGNKVTEAHDNMSKDITLVFQTSNYLDLKSWLIAFEATKKYVMSIQHDSLEYELAFKRFSPKFFEFASSTTTSIDQLITTFDKETESLYETLNCSISEYDILTLGEEKVFQFQMPTTPISTKMTQLAILSNFLTKGSWFPNAVLANIWGTTDWSEYTILPGKGKKPSSLLTIDGKRLPIRNSTIYPQYYSNELKVLDLQFKSLVFSPDQRLEKLPEELLLFKFEALWCPNKKQKFSATCFCTKDYIYCYMNSMEFICLTKISLSEIVSVEADRSSKKTLKLYDASGLQMKAIVLFSDYKLIASKLQYLLENKAIKNPNSNEEILVKFEQMEKESQEKKQEELYKIEQENSFDRKATSVSKIIKSRVTFWEMSDDASTLLNRLKKLQTEYSITYNHEYEISSKGLAHILFGDKSNAFPKCLFLARKDGEEHGKRFWYKNKDINGKSQLVRKIPFRLDMTGNFLNTGKYHRDKESKMIFATQRIVKIVDNKYYEVDLDPFFVKVPFCHLLKLSIKFVITESYDVDNHLEIKLNMTASSSSLHVLYKLEYIDSRTGKTIEKLSLAEIICQTWALKFAHSEFLLIRRVLRYYLEKIGKHGKVIKAIKLCGILGVLSNKSEEPATEKNGNSKESESMQYDIRYSCTILFLVFIKLMVYRVTNLTFVFFRILIGILLLCAEKFSRINRMMVVGLLASIMINILLSEKASVPYWSIKRAEKLFHDRLGSDKFTMQRAIYISDSDLLSSQLSVPSNNPIFEKFSEDNFNKDYQYSETRKQLAMRRNELLIELRILQDMEKQLVHDDYEKFLLEEVNKCSMVSIEMTDLWFNDTQLQNYCSICNEELEKLRPPIT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSVHGRDPK
------CCCCCCCHH		33.8428889911
153PhosphorylationFDFYQGKYDSMLASY
CCCCCCCHHHHHHHH		21.7830377154
155PhosphorylationFYQGKYDSMLASYQA
CCCCCHHHHHHHHHC		16.7730377154
159PhosphorylationKYDSMLASYQAIRIS
CHHHHHHHHHCCEEE		17.5130377154
160PhosphorylationYDSMLASYQAIRISK
HHHHHHHHHCCEEEC		9.0730377154
166PhosphorylationSYQAIRISKTSLEPS
HHHCCEEECCCCCCC		21.7430377154
201PhosphorylationLDLISAISAVKLSLD
HHHHHHHHHHHHHHH		27.0727017623
277UbiquitinationQAYRYTLKRITPSSD
HHHHHEEECCCCCCC		33.6717644757
286PhosphorylationITPSSDTSDYNIRSI
CCCCCCCCCCCCCCH		42.9927214570
288PhosphorylationPSSDTSDYNIRSIHS
CCCCCCCCCCCCHHH		16.5621440633
295PhosphorylationYNIRSIHSSKLLSKD
CCCCCHHHHCCCCCC		27.7421440633
348PhosphorylationVFGMFLLSPSKTYVE
HHHHHHCCCCCCEEE		29.3121551504
389PhosphorylationKIFGNKVTEAHDNMS
EEECCCCEECCHHCC		29.1227017623
733PhosphorylationYKIEQENSFDRKATS
HHHHHHCCCCCHHHH		27.9827717283
760PhosphorylationEMSDDASTLLNRLKK
ECCCCHHHHHHHHHH		36.6628889911
1206N-linked_GlycosylationEMTDLWFNDTQLQNY
EEECCCCCCHHHHHH		39.58-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SIP3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SIP3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SIP3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MBA1_YEASTMBA1genetic
20093466
MGR1_YEASTMGR1genetic
20093466
SAC3_YEASTSAC3genetic
20093466
PMP3_YEASTPMP3genetic
20093466
OMS1_YEASTOMS1genetic
20093466
RLA4_YEASTRPP2Bgenetic
20093466
MTO1_YEASTMTO1genetic
20093466
YGY5_YEASTYGL235Wgenetic
20093466
QCR9_YEASTQCR9genetic
20093466
CAPZB_YEASTCAP2genetic
20093466
MRX5_YEASTYJL147Cgenetic
20093466
MOG1_YEASTMOG1genetic
20093466
CBT1_YEASTCBT1genetic
20093466
CYT2_YEASTCYT2genetic
20093466
VRP1_YEASTVRP1genetic
20093466
COX7_YEASTCOX7genetic
20093466
ODP2_YEASTLAT1genetic
20093466
MAS5_YEASTYDJ1genetic
20093466
COX5A_YEASTCOX5Agenetic
20093466
WHI2_YEASTWHI2genetic
20093466
CY1_YEASTCYT1genetic
20093466
SFL1_YEASTSFL1genetic
20093466
MKK1_YEASTMKK1genetic
20093466
HAP5_YEASTHAP5genetic
20093466
RTC6_YEASTRTC6genetic
20093466
NCBP2_YEASTCBC2genetic
20093466
COX10_YEASTCOX10genetic
20093466
MSS18_YEASTMSS18genetic
20093466
QCR2_YEASTQCR2genetic
20093466
RTG3_YEASTRTG3genetic
21127252
ADA2_YEASTADA2genetic
21127252
EAF7_YEASTEAF7genetic
21127252
SWI6_YEASTSWI6genetic
21127252
DAL80_YEASTDAL80genetic
21127252
CTK1_YEASTCTK1genetic
21127252
GCR2_YEASTGCR2genetic
21127252
PTK2_YEASTPTK2genetic
21127252
CBF1_YEASTCBF1genetic
21127252
NU133_YEASTNUP133genetic
21127252
MET18_YEASTMET18genetic
21127252
HSP72_YEASTSSA2physical
22940862
SSB1_YEASTSSB1physical
22940862
HSP71_YEASTSSA1physical
22940862
KPYK1_YEASTCDC19physical
22940862
MKK1_YEASTMKK1genetic
22282571
TYSY_YEASTCDC21genetic
27708008
LCB2_YEASTLCB2genetic
27708008
KGUA_YEASTGUK1genetic
27708008
SEC20_YEASTSEC20genetic
27708008
ACT_YEASTACT1genetic
27708008
SEC39_YEASTSEC39genetic
27708008
CH10_YEASTHSP10genetic
27708008
YPK1_YEASTYPK1genetic
28774891
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SIP3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-286, AND MASSSPECTROMETRY.

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