| UniProt ID | MET18_YEAST | |
|---|---|---|
| UniProt AC | P40469 | |
| Protein Name | DNA repair/transcription protein MET18/MMS19 | |
| Gene Name | MET18 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1032 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Key component of the cytosolic iron-sulfur protein assembly (CIA) machinery that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. Acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as RAD3/XPD and DNA2, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription.. | |
| Protein Sequence | MTPDELNSAVVTFMANLNIDDSKANETASTVTDSIVHRSIKLLEVVVALKDYFLSENEVERKKALTCLTTILAKTPKDHLSKNECSVIFQFYQSKLDDQALAKEVLEGFAALAPMKYVSINEIAQLLRLLLDNYQQGQHLASTRLWPFKILRKIFDRFFVNGSSTEQVKRINDLFIETFLHVANGEKDPRNLLLSFALNKSITSSLQNVENFKEDLFDVLFCYFPITFKPPKHDPYKISNQDLKTALRSAITATPLFAEDAYSNLLDKLTASSPVVKNDTLLTLLECVRKFGGSSILENWTLLWNALKFEIMQNSEGNENTLLNPYNKDQQSDDVGQYTNYDACLKIINLMALQLYNFDKVSFEKFFTHVLDELKPNFKYEKDLKQTCQILSAIGSGNVEIFNKVISSTFPLFLINTSEVAKLKLLIMNFSFFVDSYIDLFGRTSKESLGTPVPNNKMAEYKDEIIMILSMALTRSSKAEVTIRTLSVIQFTKMIKMKGFLTPEEVSLIIQYFTEEILTDNNKNIYYACLEGLKTISEIYEDLVFEISLKKLLDLLPDCFEEKIRVNDEENIHIETILKIILDFTTSRHILVKESITFLATKLNRVAKISKSREYCFLLISTIYSLFNNNNQNENVLNEEDALALKNAIEPKLFEIITQESAIVSDNYNLTLLSNVLFFTNLKIPQAAHQEELDRYNELFISEGKIRILDTPNVLAISYAKILSALNKNCQFPQKFTVLFGTVQLLKKHAPRMTETEKLGYLELLLVLSNKFVSEKDVIGLFDWKDLSVINLEVMVWLTKGLIMQNSLESSEIAKKFIDLLSNEEIGSLVSKLFEVFVMDISSLKKFKGISWNNNVKILYKQKFFGDIFQTLVSNYKNTVDMTIKCNYLTALSLVLKHTPSQSVGPFINDLFPLLLQALDMPDPEVRVSALETLKDTTDKHHTLITEHVSTIVPLLLSLSLPHKYNSVSVRLIALQLLEMITTVVPLNYCLSYQDDVLSALIPVLSDKKRIIRKQCVDTRQVYYELGQIPFE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 244 | Acetylation | KISNQDLKTALRSAI CCCCHHHHHHHHHHH | 39.79 | 24489116 | |
| 444 | Phosphorylation | YIDLFGRTSKESLGT HHHHHCCCCHHHCCC | 44.52 | 29688323 | |
| 445 | Phosphorylation | IDLFGRTSKESLGTP HHHHCCCCHHHCCCC | 32.82 | 29688323 | |
| 448 | Phosphorylation | FGRTSKESLGTPVPN HCCCCHHHCCCCCCC | 35.52 | 28889911 | |
| 451 | Phosphorylation | TSKESLGTPVPNNKM CCHHHCCCCCCCCCC | 26.80 | 27214570 | |
| 461 | Phosphorylation | PNNKMAEYKDEIIMI CCCCCHHHHHHHHHH | 17.75 | 29688323 | |
| 537 | Phosphorylation | LEGLKTISEIYEDLV HHHHHHHHHHHHHHH | 24.15 | 27017623 | |
| 548 | Phosphorylation | EDLVFEISLKKLLDL HHHHHHHHHHHHHHH | 27.26 | 27017623 | |
| 871 | Phosphorylation | FFGDIFQTLVSNYKN HHHHHHHHHHHCCCC | 20.55 | 19823750 | |
| 874 | Phosphorylation | DIFQTLVSNYKNTVD HHHHHHHHCCCCCCC | 37.24 | 19823750 | |
| 876 | Phosphorylation | FQTLVSNYKNTVDMT HHHHHHCCCCCCCCE | 9.71 | 19823750 | |
| 879 | Phosphorylation | LVSNYKNTVDMTIKC HHHCCCCCCCCEEEC | 17.46 | 19823750 | |
| 883 | Phosphorylation | YKNTVDMTIKCNYLT CCCCCCCEEECCHHH | 16.90 | 19823750 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MET18_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MET18_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MET18_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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