KIN1_YEAST - dbPTM
KIN1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KIN1_YEAST
UniProt AC P13185
Protein Name Serine/threonine protein kinase KIN1
Gene Name KIN1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1064
Subcellular Localization Cytoplasm. Cell membrane
Peripheral membrane protein
Cytoplasmic side.
Protein Description Serine/threonine protein kinase involved in the regulation of exocytosis. Induces phosphorylation of SEC9 and its release from the plasma membrane to the cytosol..
Protein Sequence MDDYHVNTAFSMGRGNQQDDGNSESNSMHTQPSTMAPATLRMMGKSPQQQQQQNTPLMPPADIKYANNGNSHQAEQKERQVELEGKSRENAPKPNTTSQSRVSSSQGMPKQFHRKSLGDWEFVETVGAGSMGKVKLAKHRYTNEVCAVKIVNRATKAFLHKEQMLPPPKNEQDVLERQKKLEKEISRDKRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQARKFARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQLHTFCGSLYFAAPELLKANPYTGPEVDVWSFGVVLFVLVCGKVPFDDENSSVLHEKIKQGKVEYPQHLSIEVISLLSKMLVVDPKRRATLKQVVEHHWMVRGFNGPPPSYLPKRVPLTIEMLDINVLKEMYRLEFIDDVEETRSVLVSIITDPTYVLLSRQYWTLAAKMNAESSDNGNAPNITESFEDPTRAYHPMISIYYLTSEMLDRKHAKIRNQQQRQSHENIEKLSEIPESVKQRDVEVNTTAMKSEPEATLATKDTSVPFTPKNSDGTEPPLHVLIPPRLAMPEQAHTSPTSRKSSDNQRREMEYALSPTPQGNDYQQFRVPSTTGDPSEKAKFGNIFRKLSQRRKKTIEQTSVNSNNSINKPVQKTHSRAVSDFVPGFAKPSYDSNYTMNEPVKTNDSRGGNKGDFPALPADAENMVEKQREKQIEEDIMKLHDINKQNNEVAKGSGREAYAAQKFEGSDDDENHPLPPLNVAKGRKLHPSARAKSVGHARRESLKYMRPPMPSSAYPQQELIDTGFLESSDDNKSDSLGNVTSQTNDSVSVHSVNAHINSPSVEKELTDEEILQEASRAPAGSMPSIDFPRSLFLKGFFSVQTTSSKPLPIVRYKIMFVLRKMNIEFKEVKGGFVCMQRFSSNNVAAKREGTPRSIMPLSHHESIRRQGSNKYSPSSPLTTNSIHQRKTSITETYGDDKHSGTSLENIHQQGDGSEGMTTTEKEPIKFEIHIVKVRIVGLAGVHFKKISGNTWLYKELASSILKELKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MDDYHVNTAFS
----CCCCCCCCCCC		21.7219779198
8PhosphorylationMDDYHVNTAFSMGRG
CCCCCCCCCCCCCCC		28.1719779198
11PhosphorylationYHVNTAFSMGRGNQQ
CCCCCCCCCCCCCCC		20.1930377154
23PhosphorylationNQQDDGNSESNSMHT
CCCCCCCCCCCCCCC		48.1822369663
25PhosphorylationQDDGNSESNSMHTQP
CCCCCCCCCCCCCCC		33.7422369663
27PhosphorylationDGNSESNSMHTQPST
CCCCCCCCCCCCCCC		22.6322369663
30PhosphorylationSESNSMHTQPSTMAP
CCCCCCCCCCCCCCH		33.2722369663
33PhosphorylationNSMHTQPSTMAPATL
CCCCCCCCCCCHHHH		22.4621440633
34PhosphorylationSMHTQPSTMAPATLR
CCCCCCCCCCHHHHH		24.8422369663
39PhosphorylationPSTMAPATLRMMGKS
CCCCCHHHHHHCCCC		17.5322369663
46PhosphorylationTLRMMGKSPQQQQQQ
HHHHCCCCHHHHHHH		23.3925521595
55PhosphorylationQQQQQQNTPLMPPAD
HHHHHHCCCCCCHHH		17.2929688323
96PhosphorylationENAPKPNTTSQSRVS
CCCCCCCCCCHHHHH		36.0321440633
97PhosphorylationNAPKPNTTSQSRVSS
CCCCCCCCCHHHHHC		31.2619779198
98PhosphorylationAPKPNTTSQSRVSSS
CCCCCCCCHHHHHCC		24.9123749301
100PhosphorylationKPNTTSQSRVSSSQG
CCCCCCHHHHHCCCC		34.1221440633
103PhosphorylationTTSQSRVSSSQGMPK
CCCHHHHHCCCCCCC		24.1421440633
104PhosphorylationTSQSRVSSSQGMPKQ
CCHHHHHCCCCCCCH		24.6721440633
105PhosphorylationSQSRVSSSQGMPKQF
CHHHHHCCCCCCCHH		24.2121440633
302PhosphorylationDSRKQLHTFCGSLYF
CCHHHHHHHHHHHHH		29.2525521595
306PhosphorylationQLHTFCGSLYFAAPE
HHHHHHHHHHHHCHH		22.5221440633
308PhosphorylationHTFCGSLYFAAPELL
HHHHHHHHHHCHHHH		7.8922369663
350PhosphorylationPFDDENSSVLHEKIK
CCCCCCCHHHHHHHH		40.0423749301
521PhosphorylationRNQQQRQSHENIEKL
HHHHHHHHHHHHHHH		34.6519823750
529PhosphorylationHENIEKLSEIPESVK
HHHHHHHHHCCHHHH		44.5422369663
534PhosphorylationKLSEIPESVKQRDVE
HHHHCCHHHHHCCCC		29.2922369663
536UbiquitinationSEIPESVKQRDVEVN
HHCCHHHHHCCCCCC		49.2323749301
544PhosphorylationQRDVEVNTTAMKSEP
HCCCCCCCCCCCCCC		22.5521551504
545PhosphorylationRDVEVNTTAMKSEPE
CCCCCCCCCCCCCCC		21.3921551504
561PhosphorylationTLATKDTSVPFTPKN
EECCCCCCCCCCCCC		37.6228889911
565PhosphorylationKDTSVPFTPKNSDGT
CCCCCCCCCCCCCCC		27.5523749301
569PhosphorylationVPFTPKNSDGTEPPL
CCCCCCCCCCCCCCE		43.4723749301
592PhosphorylationAMPEQAHTSPTSRKS
CCCCCCCCCCCCCCC		39.1421082442
593PhosphorylationMPEQAHTSPTSRKSS
CCCCCCCCCCCCCCC		19.1317330950
595PhosphorylationEQAHTSPTSRKSSDN
CCCCCCCCCCCCCHH		40.7122890988
596PhosphorylationQAHTSPTSRKSSDNQ
CCCCCCCCCCCCHHH		40.8922890988
599PhosphorylationTSPTSRKSSDNQRRE
CCCCCCCCCHHHHHH		41.6420377248
600PhosphorylationSPTSRKSSDNQRREM
CCCCCCCCHHHHHHH		43.5521440633
609PhosphorylationNQRREMEYALSPTPQ
HHHHHHEEECCCCCC		16.1321440633
612PhosphorylationREMEYALSPTPQGND
HHHEEECCCCCCCCC		20.6825752575
614PhosphorylationMEYALSPTPQGNDYQ
HEEECCCCCCCCCCC		25.5221440633
620PhosphorylationPTPQGNDYQQFRVPS
CCCCCCCCCCCCCCC		14.2827017623
627PhosphorylationYQQFRVPSTTGDPSE
CCCCCCCCCCCCHHH		35.4323749301
628PhosphorylationQQFRVPSTTGDPSEK
CCCCCCCCCCCHHHH		28.8230377154
646PhosphorylationGNIFRKLSQRRKKTI
HHHHHHHHHHHHHHH		25.3617287358
652PhosphorylationLSQRRKKTIEQTSVN
HHHHHHHHHHHHCCC		32.5522369663
656PhosphorylationRKKTIEQTSVNSNNS
HHHHHHHHCCCCCCC		23.1122369663
657PhosphorylationKKTIEQTSVNSNNSI
HHHHHHHCCCCCCCC		20.9922369663
660PhosphorylationIEQTSVNSNNSINKP
HHHHCCCCCCCCCCC		34.9222369663
663PhosphorylationTSVNSNNSINKPVQK
HCCCCCCCCCCCCHH		31.6122369663
666UbiquitinationNSNNSINKPVQKTHS
CCCCCCCCCCHHHHH		44.9123749301
671PhosphorylationINKPVQKTHSRAVSD
CCCCCHHHHHHHHHH		14.1624961812
673PhosphorylationKPVQKTHSRAVSDFV
CCCHHHHHHHHHHCC		27.4524961812
677PhosphorylationKTHSRAVSDFVPGFA
HHHHHHHHHCCCCCC		25.0922369663
690PhosphorylationFAKPSYDSNYTMNEP
CCCCCCCCCCCCCCC		24.4121551504
700PhosphorylationTMNEPVKTNDSRGGN
CCCCCCCCCCCCCCC		44.4821440633
703PhosphorylationEPVKTNDSRGGNKGD
CCCCCCCCCCCCCCC		34.5921440633
708UbiquitinationNDSRGGNKGDFPALP
CCCCCCCCCCCCCCC		64.2323749301
756PhosphorylationKGSGREAYAAQKFEG
CCCCHHHHHHHHCCC		9.5629136822
764PhosphorylationAAQKFEGSDDDENHP
HHHHCCCCCCCCCCC		30.5722369663
791PhosphorylationHPSARAKSVGHARRE
CHHHHHHCHHHHHHH		32.1417287358
799PhosphorylationVGHARRESLKYMRPP
HHHHHHHHHHHCCCC		28.4917287358
820PhosphorylationPQQELIDTGFLESSD
CHHHHHHCCCCCCCC		23.8819795423
825PhosphorylationIDTGFLESSDDNKSD
HHCCCCCCCCCCCCC		41.0120377248
826PhosphorylationDTGFLESSDDNKSDS
HCCCCCCCCCCCCCC		39.3419795423
833PhosphorylationSDDNKSDSLGNVTSQ
CCCCCCCCCCCCCCC		45.3121551504
839PhosphorylationDSLGNVTSQTNDSVS
CCCCCCCCCCCCCEE		30.6324961812
841PhosphorylationLGNVTSQTNDSVSVH
CCCCCCCCCCCEEEE		40.5424961812
844PhosphorylationVTSQTNDSVSVHSVN
CCCCCCCCEEEEEEE		20.5420377248
846PhosphorylationSQTNDSVSVHSVNAH
CCCCCCEEEEEEEEE		20.3320377248
849PhosphorylationNDSVSVHSVNAHINS
CCCEEEEEEEEECCC		18.2120377248
856PhosphorylationSVNAHINSPSVEKEL
EEEEECCCCCHHCCC		20.2524961812
858PhosphorylationNAHINSPSVEKELTD
EEECCCCCHHCCCCH		42.6124961812
864PhosphorylationPSVEKELTDEEILQE
CCHHCCCCHHHHHHH		42.3227214570
937PhosphorylationFVCMQRFSSNNVAAK
EEEEEECCCCCCCCC		34.0527214570
948PhosphorylationVAAKREGTPRSIMPL
CCCCCCCCCCCCCCC		15.6924961812
951PhosphorylationKREGTPRSIMPLSHH
CCCCCCCCCCCCCHH		25.1728889911
956PhosphorylationPRSIMPLSHHESIRR
CCCCCCCCHHHHHHH		19.5419779198
960PhosphorylationMPLSHHESIRRQGSN
CCCCHHHHHHHCCCC		19.6224961812
966PhosphorylationESIRRQGSNKYSPSS
HHHHHCCCCCCCCCC		23.0821440633
969PhosphorylationRRQGSNKYSPSSPLT
HHCCCCCCCCCCCCC		30.0223749301
970PhosphorylationRQGSNKYSPSSPLTT
HCCCCCCCCCCCCCC		21.6622369663
972PhosphorylationGSNKYSPSSPLTTNS
CCCCCCCCCCCCCCC		38.3522369663
973PhosphorylationSNKYSPSSPLTTNSI
CCCCCCCCCCCCCCH		27.5822369663
976PhosphorylationYSPSSPLTTNSIHQR
CCCCCCCCCCCHHHC		27.5822369663
977PhosphorylationSPSSPLTTNSIHQRK
CCCCCCCCCCHHHCC		34.3522369663
979PhosphorylationSSPLTTNSIHQRKTS
CCCCCCCCHHHCCCC		21.2528152593
985PhosphorylationNSIHQRKTSITETYG
CCHHHCCCCCEEECC		27.7922890988
986PhosphorylationSIHQRKTSITETYGD
CHHHCCCCCEEECCC		30.4622369663
988PhosphorylationHQRKTSITETYGDDK
HHCCCCCEEECCCCC		23.2622890988
990PhosphorylationRKTSITETYGDDKHS
CCCCCEEECCCCCCC		24.9322890988
991PhosphorylationKTSITETYGDDKHSG
CCCCEEECCCCCCCC		16.6022890988
997PhosphorylationTYGDDKHSGTSLENI
ECCCCCCCCCCHHHH		49.8921440633
999PhosphorylationGDDKHSGTSLENIHQ
CCCCCCCCCHHHHHH		32.9019823750
1000PhosphorylationDDKHSGTSLENIHQQ
CCCCCCCCHHHHHHC		36.8920377248
1011PhosphorylationIHQQGDGSEGMTTTE
HHHCCCCCCCCCCCC		35.4019823750
1015PhosphorylationGDGSEGMTTTEKEPI
CCCCCCCCCCCCCCC		41.2321551504
1016PhosphorylationDGSEGMTTTEKEPIK
CCCCCCCCCCCCCCE		24.8619823750
1017PhosphorylationGSEGMTTTEKEPIKF
CCCCCCCCCCCCCEE		35.5721551504
1042AcetylationGLAGVHFKKISGNTW
EEEEEEEEECCCCHH		34.0324489116
1051PhosphorylationISGNTWLYKELASSI
CCCCHHHHHHHHHHH		8.2527017623
1057PhosphorylationLYKELASSILKELKL
HHHHHHHHHHHHHCC		26.7427017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KIN1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KIN1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KIN1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG19_YEASTATG19physical
10688190
SEC9_YEASTSEC9physical
15563607
6P21_YEASTPFK26physical
16319894
SOL2_YEASTSOL2physical
16319894
MGA1_YEASTMGA1physical
16319894
MCM2_YEASTMCM2physical
18719252
CKS1_YEASTCKS1genetic
19269370
OCA6_YEASTOCA6genetic
19269370
GIS1_YEASTGIS1genetic
19269370
EKI1_YEASTEKI1genetic
19269370
ISC1_YEASTISC1genetic
19269370
SSB1_YEASTSSB1physical
19536198
CSG2_YEASTCSG2genetic
20093466
XRN1_YEASTXRN1genetic
20093466
ASK10_YEASTASK10genetic
20093466
PBS2_YEASTPBS2genetic
20093466
SSO2_YEASTSSO2genetic
20093466
SCS7_YEASTSCS7genetic
20093466
RAS2_YEASTRAS2genetic
20093466
MNE1_YEASTMNE1genetic
20093466
RU2A_YEASTLEA1genetic
20093466
SVL3_YEASTSVL3genetic
20093466
ASK10_YEASTASK10physical
20489023
ATG19_YEASTATG19physical
20489023
BCK2_YEASTBCK2physical
20489023
BUD14_YEASTBUD14physical
20489023
CBK1_YEASTCBK1physical
20489023
GIS4_YEASTGIS4physical
20489023
PP12_YEASTGLC7physical
20489023
KEL1_YEASTKEL1physical
20489023
KEL2_YEASTKEL2physical
20489023
MOB2_YEASTMOB2physical
20489023
PSH1_YEASTPSH1physical
20489023
YM11_YEASTEPO1physical
20489023
ATG34_YEASTATG34physical
20489023
RGC1_YEASTRGC1physical
20489023
BUD14_YEASTBUD14physical
21118957
CBK1_YEASTCBK1physical
21118957
CG12_YEASTCLN2physical
21118957
KEL1_YEASTKEL1physical
21118957
KEL2_YEASTKEL2physical
21118957
NBP2_YEASTNBP2physical
21118957
KAPA_YEASTTPK1physical
21118957
VPS41_YEASTVPS41genetic
20526336
EFM5_YEASTAML1physical
21460040
CSK2B_YEASTCKB1physical
21460040
DJP1_YEASTDJP1physical
21460040
RDS2_YEASTRDS2physical
21460040
YIQ5_YEASTYIL165Cphysical
21460040
REI1_YEASTREI1genetic
21127252
GIS1_YEASTGIS1genetic
21127252
RPN4_YEASTRPN4genetic
21127252
VMS1_YEASTVMS1genetic
21127252
CRT10_YEASTCRT10genetic
22282571
NDI1_YEASTNDI1genetic
22282571
TAF6_YEASTTAF6genetic
22282571
YE14_YEASTTOG1genetic
22282571
CYK3_YEASTCYK3genetic
22282571
NRG1_YEASTNRG1genetic
22282571
SYF1_YEASTSYF1genetic
22282571
YMW4_YEASTYMR074Cgenetic
22282571
6P22_YEASTPFK27genetic
22282571
RBG1_YEASTRBG1genetic
22282571
RRN9_YEASTRRN9genetic
22282571
ASK10_YEASTASK10genetic
22282571
XRN1_YEASTXRN1genetic
22282571
SCS7_YEASTSCS7genetic
22282571
CSG2_YEASTCSG2genetic
22282571
RU2A_YEASTLEA1genetic
22282571
RAS2_YEASTRAS2genetic
22282571
PBS2_YEASTPBS2genetic
22282571
SSO2_YEASTSSO2genetic
22282571
KIN2_YEASTKIN2genetic
25348718
YG036_YEASTYGL036Wgenetic
27708008
XRN1_YEASTXRN1genetic
27708008
ASK10_YEASTASK10genetic
27708008
RCY1_YEASTRCY1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
VRP1_YEASTVRP1genetic
27708008
ERG2_YEASTERG2genetic
27708008
SCS7_YEASTSCS7genetic
27708008
RAS2_YEASTRAS2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KIN1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-27; THR-302;SER-534; THR-592; SER-593; SER-660; SER-663 AND SER-764, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-521; SER-593;SER-677 AND SER-764, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521; SER-646; SER-791AND SER-799, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-593; SER-764 ANDSER-986, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-764, AND MASSSPECTROMETRY.

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