PSH1_YEAST - dbPTM
PSH1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PSH1_YEAST
UniProt AC Q12161
Protein Name RING finger protein PSH1
Gene Name PSH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 406
Subcellular Localization Nucleus .
Protein Description
Protein Sequence MGDELHNRLLHQNDGTKDAILYKIIESLVCSICHDYMFVPMMTPCGHNYCYGCLNTWFASNTQKELACPQCRSDITTIPALNTTLQQYLSFILEKLRDQNDESFKKLLTTKTKEENDYKNDKEKDTLFDKVFKNSALAVADDSDDGITRCSNCHWELDPDEVEDGNVCPHCNARIRNYAGGRDEFDEEEYSEGELDEIRESMRRRRENRFASTNPFANRDDVSSEDDDSSEEEPMREHIPLGRWARSHNRSIAVDAVDDEDDEEEDEEEEEEMDSDLKDFIEDDEDDEDEDGSRRNLVLSALKNRHVIITDDEEEEQRRHATEEEDRDSDFYEHNDDGFVSGDSLDEDQKEVTRIQSSSDSEDRSLSYSGSSDVKDNNDDNTEELDDPQPKRQKRFRVVLGDSDDE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
135PhosphorylationFDKVFKNSALAVADD
HHHHHHCCCEEEECC		25.8321126336
143PhosphorylationALAVADDSDDGITRC
CEEEECCCCCCCCCC		37.8422369663
148PhosphorylationDDSDDGITRCSNCHW
CCCCCCCCCCCCCCE		31.0222890988
178PhosphorylationCNARIRNYAGGRDEF
CCHHHHHCCCCCCCC		9.2227017623
190PhosphorylationDEFDEEEYSEGELDE
CCCCHHHHCCCCHHH		18.4622369663
191PhosphorylationEFDEEEYSEGELDEI
CCCHHHHCCCCHHHH		42.2622369663
201PhosphorylationELDEIRESMRRRREN
CHHHHHHHHHHHHHH		14.0322369663
275PhosphorylationEEEEEMDSDLKDFIE
HHHHHHHHHHHHHHH		43.4622369663
293PhosphorylationDDEDEDGSRRNLVLS
CCCCCCCCHHHHHHH		40.1522369663
300PhosphorylationSRRNLVLSALKNRHV
CHHHHHHHHHHCCCE		24.8722369663
303AcetylationNLVLSALKNRHVIIT
HHHHHHHHCCCEEEC		52.2125381059
310PhosphorylationKNRHVIITDDEEEEQ
HCCCEEECCCHHHHH		26.6922369663
322PhosphorylationEEQRRHATEEEDRDS
HHHHHHCCCCHHCCC		37.4928889911
329PhosphorylationTEEEDRDSDFYEHND
CCCHHCCCCCHHCCC		30.4317330950
332PhosphorylationEDRDSDFYEHNDDGF
HHCCCCCHHCCCCCC		22.6717330950
341PhosphorylationHNDDGFVSGDSLDED
CCCCCCCCCCCCCCC		34.3228889911
344PhosphorylationDGFVSGDSLDEDQKE
CCCCCCCCCCCCHHH		41.0417330950
353PhosphorylationDEDQKEVTRIQSSSD
CCCHHHHHEECCCCC		24.1324961812
357PhosphorylationKEVTRIQSSSDSEDR
HHHHEECCCCCCCCC		29.4521440633
358PhosphorylationEVTRIQSSSDSEDRS
HHHEECCCCCCCCCC		23.0728889911
359PhosphorylationVTRIQSSSDSEDRSL
HHEECCCCCCCCCCC		50.8621440633
361PhosphorylationRIQSSSDSEDRSLSY
EECCCCCCCCCCCCC		43.2624961812
365PhosphorylationSSDSEDRSLSYSGSS
CCCCCCCCCCCCCCC		33.7124961812
367PhosphorylationDSEDRSLSYSGSSDV
CCCCCCCCCCCCCCC		20.6424961812
369PhosphorylationEDRSLSYSGSSDVKD
CCCCCCCCCCCCCCC		28.9024961812
371PhosphorylationRSLSYSGSSDVKDNN
CCCCCCCCCCCCCCC		19.8824961812
382PhosphorylationKDNNDDNTEELDDPQ
CCCCCCCCCCCCCCC		37.5222890988
403PhosphorylationFRVVLGDSDDE----
EEEECCCCCCC----		45.2022369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PSH1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PSH1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PSH1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
H2B1_YEASTHTB1physical
11805837
SPT16_YEASTSPT16physical
11805837
H2A1_YEASTHTA1physical
11805837
H2B2_YEASTHTB2physical
11805837
SYP1_YEASTSYP1physical
11805837
NOB1_YEASTNOB1physical
11805837
GAC1_YEASTGAC1physical
11805837
H4_YEASTHHF1physical
11805837
KNS1_YEASTKNS1physical
11805837
H2A2_YEASTHTA2physical
11805837
POB3_YEASTPOB3physical
11805837
EDE1_YEASTEDE1physical
11805837
MAM33_YEASTMAM33physical
11805837
TBP7_YEASTYTA7genetic
17314980
LSM6_YEASTLSM6genetic
17314980
LSM1_YEASTLSM1genetic
17314980
PFD6_YEASTYKE2genetic
17314980
PAT1_YEASTPAT1genetic
17314980
H4_YEASTHHF1genetic
17314980
UBX1_YEASTSHP1genetic
17314980
PFD1_YEASTPFD1genetic
17314980
ASF1_YEASTASF1genetic
17314980
PFD4_YEASTGIM3genetic
17314980
SRB8_YEASTSRB8genetic
17314980
JHD2_YEASTJHD2genetic
17314980
RPA34_YEASTRPA34genetic
17314980
GET2_YEASTGET2genetic
17314980
CIN8_YEASTCIN8genetic
17314980
RPN10_YEASTRPN10genetic
17314980
VPS8_YEASTVPS8genetic
17314980
CDC73_YEASTCDC73genetic
17314980
ARO1_YEASTARO1genetic
17314980
DAL80_YEASTDAL80physical
18719252
PHS_YEASTYHL018Wphysical
18719252
SAC1_YEASTSAC1genetic
19547744
SAC3_YEASTSAC3genetic
19547744
YIH1_YEASTYIH1genetic
20093466
PAT1_YEASTPAT1genetic
20093466
SSD1_YEASTSSD1genetic
20093466
LSM6_YEASTLSM6genetic
20093466
ATG1_YEASTATG1genetic
20093466
MED5_YEASTNUT1genetic
20093466
TBP7_YEASTYTA7genetic
20093466
SSP1_YEASTSSP1genetic
20093466
LSM1_YEASTLSM1genetic
20093466
ASF1_YEASTASF1genetic
20093466
HIR3_YEASTHIR3genetic
20093466
SAC1_YEASTSAC1genetic
20093466
MMS22_YEASTMMS22genetic
20093466
SOK2_YEASTSOK2genetic
20093466
NST1_YEASTNST1genetic
20093466
EOS1_YEASTEOS1genetic
20093466
TBP6_YEASTYTA6genetic
20093466
KAR3_YEASTKAR3genetic
20093466
CENPA_YEASTCSE4physical
21070970
CENPA_YEASTCSE4genetic
21070970
PSH1_YEASTPSH1physical
21070970
H2AZ_YEASTHTZ1physical
21070970
MIF2_YEASTMIF2physical
21070970
AME1_YEASTAME1physical
21070970
OKP1_YEASTOKP1physical
21070970
MCM21_YEASTMCM21physical
21070970
CTF19_YEASTCTF19physical
21070970
NNF1_YEASTNNF1physical
21070970
NSL1_YEASTNSL1physical
21070970
MTW1_YEASTMTW1physical
21070970
DSN1_YEASTDSN1physical
21070970
NKP1_YEASTNKP1physical
21070970
NKP2_YEASTNKP2physical
21070970
IML3_YEASTIML3physical
21070970
MCM16_YEASTMCM16physical
21070970
MCM22_YEASTMCM22physical
21070970
CHL4_YEASTCHL4physical
21070970
CTF3_YEASTCTF3physical
21070970
H2A1_YEASTHTA1physical
21070970
H2A2_YEASTHTA2physical
21070970
H2B1_YEASTHTB1physical
21070970
H2B2_YEASTHTB2physical
21070970
H3_YEASTHHT1physical
21070970
H4_YEASTHHF1physical
21070970
PSH1_YEASTPSH1physical
21070971
CENPA_YEASTCSE4physical
21070971
CENPA_YEASTCSE4genetic
21070971
UBE2H_HUMANUBE2Hphysical
21070970
UB2D1_HUMANUBE2D1physical
21070971
CENPA_YEASTCSE4genetic
23525333
UBI4P_YEASTUBI4genetic
23525333
ATG1_YEASTATG1genetic
22282571
CENPA_YEASTCSE4physical
24514906
SPT16_YEASTSPT16physical
25128498
CENPA_YEASTCSE4physical
25128498
UB2D1_HUMANUBE2D1physical
25128498
CENPA_YEASTCSE4genetic
25128498
CENPA_YEASTCSE4physical
25183013
CSK21_YEASTCKA1physical
25183013
CSK22_YEASTCKA2physical
25183013
CSK2B_YEASTCKB1physical
25183013
CSK2C_YEASTCKB2physical
25183013
PAT1_YEASTPAT1physical
25833709
CENPA_YEASTCSE4physical
25833709
CSK22_YEASTCKA2physical
26508657
CENPA_YEASTCSE4physical
26508657
EDE1_YEASTEDE1physical
26508657
H4_YEASTHHF1physical
26508657
H3_YEASTHHT1physical
26508657
H2B1_YEASTHTB1physical
26508657
LSB5_YEASTLSB5physical
26508657
NOP58_YEASTNOP58physical
26508657
PSB3_YEASTPUP3physical
26508657
XRN2_YEASTRAT1physical
26508657
RPA1_YEASTRPA190physical
26508657
RPN10_YEASTRPN10physical
26508657
SLA1_YEASTSLA1physical
26508657
SPT16_YEASTSPT16physical
26508657
CENPA_YEASTCSE4physical
27794026
YOR1_YEASTYOR1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
H4_YEASTHHF1genetic
27708008
PAT1_YEASTPAT1genetic
27708008
CSM1_YEASTCSM1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
LSM6_YEASTLSM6genetic
27708008
MED5_YEASTNUT1genetic
27708008
ATG1_YEASTATG1genetic
27708008
TBP7_YEASTYTA7genetic
27708008
ASF1_YEASTASF1genetic
27708008
LSM1_YEASTLSM1genetic
27708008
YJ24_YEASTKCH1genetic
27708008
MMS22_YEASTMMS22genetic
27708008
VRP1_YEASTVRP1genetic
27708008
EOS1_YEASTEOS1genetic
27708008
DIA2_YEASTDIA2genetic
27708008
TBP6_YEASTYTA6genetic
27708008
KAR3_YEASTKAR3genetic
27708008
SLX5_YEASTSLX5genetic
26960795
UBR2_YEASTUBR2genetic
26891228
ASF1B_HUMANASF1Bphysical
27107014
ASF1A_HUMANASF1Aphysical
27107014
ZF64A_HUMANZFP64physical
27107014
ZF64B_HUMANZFP64physical
27107014
THAP1_HUMANTHAP1physical
27107014
GKAP1_HUMANGKAP1physical
27107014
ZN250_HUMANZNF250physical
27107014
CCD33_HUMANCCDC33physical
27107014
BEND7_HUMANBEND7physical
27107014
COIL_HUMANCOILphysical
27107014
CC106_HUMANCCDC106physical
27107014
DPPA4_HUMANDPPA4physical
27107014
AL2SB_HUMANALS2CR12physical
27107014
NFYA_HUMANNFYAphysical
27107014
ZBT26_HUMANZBTB26physical
27107014
RABX5_HUMANRABGEF1physical
27107014
ZKSC4_HUMANZKSCAN4physical
27107014
ZN408_HUMANZNF408physical
27107014
ZN473_HUMANZNF473physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PSH1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143; SER-191 ANDTHR-310, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191 AND THR-310, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143; THR-310 ANDSER-403, AND MASS SPECTROMETRY.

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