| UniProt ID | KNS1_YEAST | |
|---|---|---|
| UniProt AC | P32350 | |
| Protein Name | Dual specificity protein kinase KNS1 | |
| Gene Name | KNS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 737 | |
| Subcellular Localization | ||
| Protein Description | Nonessential protein kinase.. | |
| Protein Sequence | MSQNIQIGTRKRSRANMNNSTTTGPANNTSSNKTFLDNFEETRTNKLLDEMFARQNSFLTDNLRNSLDLNQADNPLRPRQHQHQLFLDNENAIELDEEPRIINTTINNSNNHNSSRVDEDADDDIIFIKEQPIQFSSPLILPSSSSINNNNNIVTSNNPGCGTAATSNSTYITTPKKFKKQRTISLPQLPLSKLSYQSNYFNVPDQTNAIVPRVTQTENELLHLTGSCAKTLEGNKAVNLTIAHSTSPFSNPPAQIASLPQSNLKKQIGSSLRKFTSNGSSESASSNKSNFKTDKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLKCIDNKYEPNYVAVKVIRAVDRYREAAKTELRILQTILNNDPQGQFQCLLLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLKPENILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHENLEHMAMMQRINGTPFPTDIIDKMFYKSKHKLGNSPSDLNSTVIKHFDRKTLSLQWPEKNKRGDTITTEKSMKRVLQSCDRLDIYISKVLKQDYGDSLSINWNLPPEKNWSLINSKLAWKRQTHSSSSSTTDELDKETFLFWYWFIDLLRKMFEFDPTKRITAKDALDHEWFNLGILDDGIATYNNTQG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSQNIQIGT ------CCCCCCCCC | 31.75 | 28889911 | |
| 9 | Phosphorylation | SQNIQIGTRKRSRAN CCCCCCCCCCCCCCC | 34.35 | 28889911 | |
| 13 | Phosphorylation | QIGTRKRSRANMNNS CCCCCCCCCCCCCCC | 38.49 | 22369663 | |
| 20 | Phosphorylation | SRANMNNSTTTGPAN CCCCCCCCCCCCCCC | 23.33 | 22369663 | |
| 21 | Phosphorylation | RANMNNSTTTGPANN CCCCCCCCCCCCCCC | 30.42 | 22369663 | |
| 57 | Phosphorylation | EMFARQNSFLTDNLR HHHHHCCCHHCHHHH | 17.19 | 22369663 | |
| 60 | Phosphorylation | ARQNSFLTDNLRNSL HHCCCHHCHHHHHHC | 22.34 | 22369663 | |
| 66 | Phosphorylation | LTDNLRNSLDLNQAD HCHHHHHHCCCCCCC | 19.47 | 22369663 | |
| 109 | Phosphorylation | INTTINNSNNHNSSR EEEEECCCCCCCCCC | 34.22 | 28889911 | |
| 183 | Phosphorylation | KKFKKQRTISLPQLP HHHCCCCEECCCCCC | 16.66 | 29136822 | |
| 185 | Phosphorylation | FKKQRTISLPQLPLS HCCCCEECCCCCCHH | 33.12 | 25752575 | |
| 192 | Phosphorylation | SLPQLPLSKLSYQSN CCCCCCHHHCCCCCC | 29.61 | 19823750 | |
| 193 | Ubiquitination | LPQLPLSKLSYQSNY CCCCCHHHCCCCCCC | 49.49 | 17644757 | |
| 215 | Phosphorylation | NAIVPRVTQTENELL CCCCCCEECCHHHHH | 30.93 | 28889911 | |
| 230 | Ubiquitination | HLTGSCAKTLEGNKA HHHHHHHHHCCCCCE | 58.95 | 17644757 | |
| 241 | Phosphorylation | GNKAVNLTIAHSTSP CCCEEEEEEECCCCC | 15.77 | 22369663 | |
| 245 | Phosphorylation | VNLTIAHSTSPFSNP EEEEEECCCCCCCCC | 22.89 | 22369663 | |
| 246 | Phosphorylation | NLTIAHSTSPFSNPP EEEEECCCCCCCCCC | 30.47 | 20377248 | |
| 247 | Phosphorylation | LTIAHSTSPFSNPPA EEEECCCCCCCCCCH | 27.28 | 20377248 | |
| 250 | Phosphorylation | AHSTSPFSNPPAQIA ECCCCCCCCCCHHHH | 52.38 | 22369663 | |
| 258 | Phosphorylation | NPPAQIASLPQSNLK CCCHHHHCCCHHHHH | 42.06 | 22369663 | |
| 262 | Phosphorylation | QIASLPQSNLKKQIG HHHCCCHHHHHHHHH | 42.04 | 22369663 | |
| 271 | Phosphorylation | LKKQIGSSLRKFTSN HHHHHHHHHHHHHCC | 27.29 | 28889911 | |
| 276 | Phosphorylation | GSSLRKFTSNGSSES HHHHHHHHCCCCCCC | 25.07 | 28889911 | |
| 277 | Phosphorylation | SSLRKFTSNGSSESA HHHHHHHCCCCCCCC | 42.18 | 17563356 | |
| 280 | Phosphorylation | RKFTSNGSSESASSN HHHHCCCCCCCCCCC | 34.87 | 23749301 | |
| 281 | Phosphorylation | KFTSNGSSESASSNK HHHCCCCCCCCCCCC | 36.65 | 23749301 | |
| 283 | Phosphorylation | TSNGSSESASSNKSN HCCCCCCCCCCCCCC | 35.08 | 30377154 | |
| 295 | Ubiquitination | KSNFKTDKDGHYVYQ CCCCCCCCCCCEEEE | 71.49 | 17644757 | |
| 309 | Phosphorylation | QENDIFGSGGRFVVK ECCCCCCCCCCEEEE | 27.59 | 28889911 | |
| 364 | Phosphorylation | TELRILQTILNNDPQ HHHHHHHHHHHCCCC | 24.80 | 28889911 | |
| 386 | Ubiquitination | LRECFDYKNHICLVT HHHHHCCCCCEEEEE | 43.84 | 17644757 | |
| 465 | Phosphorylation | LPLKTVQSLSKRRRE CCHHHHHHHHHHHHH | 30.21 | 27017623 | |
| 562 | Phosphorylation | MMQRINGTPFPTDII HHHHHCCCCCCHHHH | 19.78 | 25752575 | |
| 579 | Ubiquitination | MFYKSKHKLGNSPSD HHHHCCCCCCCCHHH | 62.92 | 17644757 | |
| 583 | Phosphorylation | SKHKLGNSPSDLNST CCCCCCCCHHHHCHH | 24.79 | 25752575 | |
| 585 | Phosphorylation | HKLGNSPSDLNSTVI CCCCCCHHHHCHHHH | 55.33 | 24961812 | |
| 589 | Phosphorylation | NSPSDLNSTVIKHFD CCHHHHCHHHHHHCC | 31.20 | 27017623 | |
| 593 | Ubiquitination | DLNSTVIKHFDRKTL HHCHHHHHHCCCCEE | 33.60 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KNS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KNS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KNS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277, AND MASSSPECTROMETRY. | |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-562, AND MASSSPECTROMETRY. | |
