DPH7_YEAST - dbPTM
DPH7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DPH7_YEAST
UniProt AC P38332
Protein Name Diphthine methyltransferase
Gene Name RRT2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 387
Subcellular Localization Cytoplasm . Endosome . Recruited to endosomes in cells in which increased recycling of internalized plasma membrane proteins occurs.
Protein Description Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate in diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EFT1 and EFT2). Also plays a role in the regulation of the retromer complex and is required for the recycling from endosomes of plasma membrane proteins like CAN1 and MUP1. Identified in a screen for mutants with decreased levels of rDNA transcription..
Protein Sequence MDSIQESDVLNAVKTKLPPCCLRIFRNKIILVGTYDLDKSTGYRSGSLDVFTMDLKLLCSNNTYGAILDLKLSPFDDTLICTAHSTGNIMLWRIRCTDKDDFQSNELDIHAIANLQLFEKDVLIASCHFSPLDCKKLLVTNTAGEAATIDIRTLSVQFTASAIAQAYSKLDKIDYEVQGATEKVIHVESGQFLKPHELECWTAEFGSLQPFQDVVFTGGDDSRIMAHDLRSKEFIWSNNRIHDAGVVSIKCSQPNFRNNKPTSIITGSYDDNIRSLDLRMMGESIFPGANVPTVNKLACDLGGGVWRFVESPIDQEQSHHNGSDRLLVCCMYNGAKVVTMNDNSDEYFQIQHYLKKGHDSMCYGGDWSNSLIATCSFYDNSLQTWIV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
126PhosphorylationEKDVLIASCHFSPLD
ECCEEEEECCCCCCC		27017623
142PhosphorylationKKLLVTNTAGEAATI
CEEEEECCCCCEEEE		27017623
167PhosphorylationASAIAQAYSKLDKID
HHHHHHHHHHHHCCC		28132839
175PhosphorylationSKLDKIDYEVQGATE
HHHHCCCEEEECCEE		28132839
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DPH7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DPH7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DPH7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
URC2_YEASTURC2physical
11283351
WDR6_YEASTRTT10physical
21880895
ADY4_YEASTADY4genetic
27708008
ETR1_YEASTETR1genetic
27708008
YMC2_YEASTYMC2genetic
27708008
YCA2_YEASTYCL002Cgenetic
27708008
PAT1_YEASTPAT1genetic
27708008
RPA14_YEASTRPA14genetic
27708008
EF2_YEASTEFT2genetic
27708008
RAD4_YEASTRAD4genetic
27708008
ODPA_YEASTPDA1genetic
27708008
RL24A_YEASTRPL24Agenetic
27708008
DBF2_YEASTDBF2genetic
27708008
SKN1_YEASTSKN1genetic
27708008
TBP7_YEASTYTA7genetic
27708008
ATG32_YEASTATG32genetic
27708008
AIM21_YEASTAIM21genetic
27708008
GSH1_YEASTGSH1genetic
27708008
RL17B_YEASTRPL17Bgenetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
PXA2_YEASTPXA2genetic
27708008
ACE2_YEASTACE2genetic
27708008
YL149_YEASTYLR149Cgenetic
27708008
YNJ5_YEASTYNL095Cgenetic
27708008
IZH2_YEASTIZH2genetic
27708008
MSB4_YEASTMSB4genetic
27708008
CHL1_YEASTCHL1genetic
27708008
ALDH6_YEASTALD6genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DPH7_YEAST

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Related Literatures of Post-Translational Modification

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