RAD4_YEAST - dbPTM
RAD4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAD4_YEAST
UniProt AC P14736
Protein Name DNA repair protein RAD4
Gene Name RAD4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 754
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents..
Protein Sequence MNEDLPKEYFELIRKALNEKEAEKAPLSRRRRVRRKNQPLPDAKKKFKTGLNELPRESVVTVNLDSSDDGVVTVPTDDSVEEIQSSEEDYDSEEFEDVTDGNEVAGVEDISVEIKPSSKRNSDARRTSRNVCSNEERKRRKYFHMLYLVCLMVHGFIRNEWINSKRLSRKLSNLVPEKVFELLHPQKDEELPLRSTRKLLDGLKKCMELWQKHWKITKKYDNVGLYMRTWKEIEMSANNKRKFKTLKRSDFLRAVSKGHGDPDISVQGFVAMLRACNVNARLIMSCQPPDFTNMKIDTSLNGNNAYKDMVKYPIFWCEVWDKFSKKWITVDPVNLKTIEQVRLHSKLAPKGVACCERNMLRYVIAYDRKYGCRDVTRRYAQWMNSKVRKRRITKDDFGEKWFRKVITALHHRKRTKIDDYEDQYFFQRDESEGIPDSVQDLKNHPYYVLEQDIKQTQIVKPGCKECGYLKVHGKVGKVLKVYAKRDIADLKSARQWYMNGRILKTGSRCKKVIKRTVGRPKGEAEEEDERLYSFEDTELYIPPLASASGEITKNTFGNIEVFAPTMIPGNCCLVENPVAIKAARFLGVEFAPAVTSFKFERGSTVKPVLSGIVVAKWLREAIETAIDGIEFIQEDDNRKEHLLGALESWNTLLLKLRIRSKLNSTYGKIAEEEPNVTKEQNIADNHDNTETFMGGGFLPGIANHEARPYSEPSEPEDSLDYVSVDKAEESATDDDVGEDYSDFMKELEMSEESD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24AcetylationLNEKEAEKAPLSRRR
HCHHHHHHCCCHHHH		63.4525381059
236PhosphorylationTWKEIEMSANNKRKF
EHHHHHHHCCCHHHC		18.3028889911
376PhosphorylationKYGCRDVTRRYAQWM
CCCCHHHHHHHHHHH		17.4528889911
437PhosphorylationESEGIPDSVQDLKNH
CCCCCCCHHHHHHCC		19.1425704821
730PhosphorylationSVDKAEESATDDDVG
EECHHHHCCCCCCCC		28.1528889911
732PhosphorylationDKAEESATDDDVGED
CHHHHCCCCCCCCCC		49.6021551504
740PhosphorylationDDDVGEDYSDFMKEL
CCCCCCCHHHHHHHH		13.0628889911
741PhosphorylationDDVGEDYSDFMKELE
CCCCCCHHHHHHHHH		36.3721551504
750PhosphorylationFMKELEMSEESD---
HHHHHHHCCCCC---		28.9222890988
753PhosphorylationELEMSEESD------
HHHHCCCCC------		44.5622890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRAD7P06779
PMID:22199232
-KUbiquitinationE3 ubiquitin ligaseUFD4P33202
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAD4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAD4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAD23_YEASTRAD23physical
10688190
RS31_YEASTRPS31physical
10688190
RAD23_YEASTRAD23physical
11259433
RAD23_YEASTRAD23physical
9837874
RAD23_YEASTRAD23physical
9001217
RAD7_YEASTRAD7physical
9001217
RAD23_YEASTRAD23physical
15601997
FBRL_YEASTNOP1physical
16554755
NOP56_YEASTNOP56physical
16554755
NOP58_YEASTNOP58physical
16554755
RAD23_YEASTRAD23physical
9685610
SNF5_YEASTSNF5physical
17013386
MMS4_YEASTMMS4genetic
17314980
GET2_YEASTGET2genetic
17314980
SWC5_YEASTSWC5genetic
17314980
RAD23_YEASTRAD23physical
18387345
RAD34_YEASTRAD34genetic
18936173
SSB1_YEASTSSB1physical
19536198
OSH1_YEASTSWH1genetic
20093466
ETR1_YEASTETR1genetic
20093466
CCZ1_YEASTCCZ1genetic
20093466
SEC66_YEASTSEC66genetic
20093466
SGF29_YEASTSGF29genetic
20093466
RIM1_YEASTRIM1genetic
20093466
SAC3_YEASTSAC3genetic
20093466
SPT3_YEASTSPT3genetic
20093466
PALF_YEASTRIM8genetic
20093466
TFS2_YEASTDST1genetic
20093466
YG34_YEASTYGR122Wgenetic
20093466
PACC_YEASTRIM101genetic
20093466
DAP2_YEASTDAP2genetic
20093466
IMPX_YEASTIMP2genetic
20093466
EST3_YEASTEST3genetic
20093466
RS21B_YEASTRPS21Bgenetic
20093466
DPH4_YEASTJJJ3genetic
20093466
NNRD_YEASTYKL151Cgenetic
20093466
MRT4_YEASTMRT4genetic
20093466
RL8B_YEASTRPL8Bgenetic
20093466
RAD5_YEASTRAD5genetic
20093466
COA4_YEASTCOA4genetic
20093466
GTR1_YEASTGTR1genetic
20093466
AMPD_YEASTAMD1genetic
20093466
HFA1_YEASTHFA1genetic
20093466
KU70_YEASTYKU70genetic
20093466
SWS2_YEASTSWS2genetic
20093466
CISY1_YEASTCIT1genetic
20093466
VPS27_YEASTVPS27genetic
20093466
NDJ1_YEASTNDJ1genetic
20093466
SDHF2_YEASTSDH5genetic
20093466
DCAM_YEASTSPE2genetic
20093466
ALG6_YEASTALG6genetic
20093466
COQ7_YEASTCAT5genetic
20093466
FABD_YEASTMCT1genetic
20093466
ALG5_YEASTALG5genetic
20093466
TCO89_YEASTTCO89genetic
20093466
OYE3_YEASTOYE3genetic
20093466
ELP3_YEASTELP3genetic
20093466
LEE1_YEASTLEE1genetic
20093466
UBA3_YEASTUBA3genetic
20093466
OPY2_YEASTOPY2genetic
20093466
RAD18_YEASTRAD18genetic
17938264
UBP3_YEASTUBP3physical
20876584
RAD51_YEASTRAD51genetic
21151658
PRS6A_YEASTRPT5physical
19889839
UFD2_YEASTUFD2physical
19889839
TFB1_YEASTTFB1physical
23295669
CDC20_YEASTCDC20genetic
24707403
RAD52_YEASTRAD52genetic
24998930
RAD23_YEASTRAD23physical
25562780
ACT_YEASTACT1genetic
27708008
SEC12_YEASTSEC12genetic
27708008
CH10_YEASTHSP10genetic
27708008
SYA_YEASTALA1genetic
27708008
ETR1_YEASTETR1genetic
27708008
SGF29_YEASTSGF29genetic
27708008
RIM1_YEASTRIM1genetic
27708008
THRC_YEASTTHR4genetic
27708008
VPS41_YEASTVPS41genetic
27708008
RV167_YEASTRVS167genetic
27708008
TFS2_YEASTDST1genetic
27708008
IMPX_YEASTIMP2genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
DHOM_YEASTHOM6genetic
27708008
NNRD_YEASTYKL151Cgenetic
27708008
RAD5_YEASTRAD5genetic
27708008
TOP3_YEASTTOP3genetic
27708008
RS3A2_YEASTRPS1Bgenetic
27708008
RIM13_YEASTRIM13genetic
27708008
SWS2_YEASTSWS2genetic
27708008
CISY1_YEASTCIT1genetic
27708008
SDHF2_YEASTSDH5genetic
27708008
ALG6_YEASTALG6genetic
27708008
VAM3_YEASTVAM3genetic
27708008
COQ7_YEASTCAT5genetic
27708008
RMI1_YEASTRMI1genetic
27708008
LEE1_YEASTLEE1genetic
27708008
UBA3_YEASTUBA3genetic
27708008
SDHB_YEASTSDH2genetic
27453043
AIM33_YEASTAIM33genetic
27453043
RAD52_YEASTRAD52genetic
27453043
CYPC_YEASTCPR3genetic
27453043
BUB1_YEASTBUB1genetic
27453043
RAD1_YEASTRAD1genetic
27453043
DCAM_YEASTSPE2genetic
27453043
DCOR_YEASTSPE1genetic
27453043
WSS1_YEASTWSS1genetic
27453043
RAD5_YEASTRAD5genetic
27453043
UBP7_YEASTUBP7genetic
26740628
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAD4_YEAST

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Related Literatures of Post-Translational Modification

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