SDHF2_YEAST - dbPTM
SDHF2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SDHF2_YEAST
UniProt AC Q08230
Protein Name Succinate dehydrogenase assembly factor 2, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03057, ECO:0000303|PubMed:23062074}
Gene Name SDH5 {ECO:0000255|HAMAP-Rule:MF_03057, ECO:0000303|PubMed:19628817}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 162
Subcellular Localization Mitochondrion matrix .
Protein Description Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDH1 of the SDH catalytic dimer. It is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDH1 in a conformation that is susceptible to autocatalytic FAD attachment. [PubMed: 19628817 Does not bind FAD or FADH(2) in vitro]
Protein Sequence MHNMFPALTKTLSLQGYKIINSQTGSAAWSCGRRWFSSDKDDHDDVVTRIKIAPIKRTNEPLDKKRARLIYQSRKRGILETDLLLSGFAAKYLKKMNEEELEEYDSLLNELDWDIYYWATKNFKTSPLPDKWANSKLLKQLQEFSENKEKEILSMPDLSKYQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
81PhosphorylationRKRGILETDLLLSGF
HHCCCHHHHHHHHHH		28.6222369663
86PhosphorylationLETDLLLSGFAAKYL
HHHHHHHHHHHHHHH		31.6622369663
131AcetylationKTSPLPDKWANSKLL
CCCCCCCHHHHHHHH		46.3924489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SDHF2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SDHF2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SDHF2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SDHA_YEASTSDH1physical
19628817
FZO1_YEASTFZO1genetic
21987634
IPK1_YEASTIPK1genetic
21987634
DLDH_YEASTLPD1genetic
21987634
TDA5_YEASTTDA5genetic
21987634
SDHA_YEASTSDH1physical
23043141
SDHA_YEASTSDH1genetic
23062074
YCZ2_YEASTYCR102Cgenetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
CHK1_YEASTCHK1genetic
27708008
SNF5_YEASTSNF5genetic
27708008
RV161_YEASTRVS161genetic
27708008
MTU1_YEASTSLM3genetic
27708008
INO2_YEASTINO2genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
RV167_YEASTRVS167genetic
27708008
RAD4_YEASTRAD4genetic
27708008
MRM2_YEASTMRM2genetic
27708008
MED5_YEASTNUT1genetic
27708008
ASK10_YEASTASK10genetic
27708008
TRX2_YEASTTRX2genetic
27708008
PTK2_YEASTPTK2genetic
27708008
IXR1_YEASTIXR1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
YRA2_YEASTYRA2genetic
27708008
ERG3_YEASTERG3genetic
27708008
VPS9_YEASTVPS9genetic
27708008
RAD14_YEASTRAD14genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SDHF2_YEAST

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Related Literatures of Post-Translational Modification

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