FZO1_YEAST - dbPTM
FZO1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FZO1_YEAST
UniProt AC P38297
Protein Name Mitofusin FZO1
Gene Name FZO1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 855
Subcellular Localization Mitochondrion outer membrane
Multi-pass membrane protein . Detected at the periphery of mitochondrial contact sites that form before mitochondrial fusion.
Protein Description Essential transmembrane GTPase, which mediates mitochondrial fusion. [PubMed: 9685359]
Protein Sequence MSEGKQQFKDSNKPHKDSTDQDDDAATIVPQTLTYSRNEGHFLGSNFHGVTDDRTTLFDGEEGRREDDLLPSLRSSNSKAHLISSQLSQWNYNNNRVLLKRSILKTQAFMDQLQEENNIRPIFIAANDEREKLHVLQLNIKLDGQYNTKEKNGFNIEKKALSKLFHSQIVSVTNHLNALKKRVDDVSSKVFITGDVNTGKSALCNSLLKQRLLPEDQLPCTNVFSEILEARENDGIEEVHAIPLNIAPTLKEAIDMYSIQNPKTYEIHTLKELPDLVPQNGKYALLKIYIKDDKRPASTSLLRNGTVDISLIDSPGLNMDSLQTAEVMSRQEEIDLVIFVVNAENQLTLSAKEFISLASREKKLMFFVVKKFDKIRDKQRCKELILKQIRDLSPETYKRAADFVHFVSKNGDELPHYHNENDNEDHGDRKPDDDPYSSSDPDPDFDSLEDSLRNFVLKKRSLSKLLPAKTYLSKLLSDIIMISKSNMKMYSEEEIKINEQLETLRPEILSARAKCNDLTTSVDQMAEQTITMTYNNTKEALLNALDVPLHEYPKYQGLGQIYDFIFSTEAFIANQIDESIGSSELFAKQKTDLLVKKIYEIGKNELGDDFMCERVFRSELMFRKRKHLIGKRLKVSLSITDLFAPTWKGFLSYLSWQKPVTAPLPDIEGQTNEGQIGLMKYLGLKNYPLTQYWSRPSLLFTSKIPTLTLYFLGSTKVVGNIILNGIKLSSWSSLKKLSVPVIVVGSLLGLTYLIHDLPRALPMNLSIKYKRKLQELDYIHLNAQRTSNEVRDVLRVPTREILRSCEIIMDKKQITKKELENKKESNLLSIKFFQSLYEGTVAQKLMVEEINLDID
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
75PhosphorylationDLLPSLRSSNSKAHL
CCHHHHHCCCCCHHH		38.8828889911
78PhosphorylationPSLRSSNSKAHLISS
HHHHCCCCCHHHHHH		32.9223749301
79UbiquitinationSLRSSNSKAHLISSQ
HHHCCCCCHHHHHHH		44.0423749301
88PhosphorylationHLISSQLSQWNYNNN
HHHHHHHHHCCCCCC		26.0519779198
163UbiquitinationIEKKALSKLFHSQIV
HHHHHHHHHHHHHHH		56.9017644757
180UbiquitinationTNHLNALKKRVDDVS
HHHHHHHHHHHHCCC		35.8017644757
181UbiquitinationNHLNALKKRVDDVSS
HHHHHHHHHHHCCCC		59.5117644757
189UbiquitinationRVDDVSSKVFITGDV
HHHCCCCCEEEECCC		33.3917644757
200UbiquitinationTGDVNTGKSALCNSL
ECCCCCCHHHHHHHH		30.43PubMed
209UbiquitinationALCNSLLKQRLLPED
HHHHHHHHCCCCCHH		38.3723749301
251UbiquitinationLNIAPTLKEAIDMYS
CCCCCCHHHHHHHHC		47.8017644757
263UbiquitinationMYSIQNPKTYEIHTL
HHCCCCCCEEEEEEC		71.8817644757
298PhosphorylationKDDKRPASTSLLRNG
CCCCCCCCCHHHHCC		22.6327214570
370UbiquitinationKLMFFVVKKFDKIRD
HHHEEHHHCHHHHCC		42.2823749301
398UbiquitinationDLSPETYKRAADFVH
HCCHHHHHHHHHHHH		42.8723749301
409UbiquitinationDFVHFVSKNGDELPH
HHHHHHCCCCCCCCC		60.7017644757
436PhosphorylationRKPDDDPYSSSDPDP
CCCCCCCCCCCCCCC		28.3419684113
437PhosphorylationKPDDDPYSSSDPDPD
CCCCCCCCCCCCCCC		28.8419684113
438PhosphorylationPDDDPYSSSDPDPDF
CCCCCCCCCCCCCCC		32.6819684113
439PhosphorylationDDDPYSSSDPDPDFD
CCCCCCCCCCCCCCC		47.4219684113
464UbiquitinationLKKRSLSKLLPAKTY
HHHHCHHHHHCHHHH		60.3723317502
596UbiquitinationQKTDLLVKKIYEIGK
HHHHHHHHHHHHHCC		33.1617644757
597UbiquitinationKTDLLVKKIYEIGKN
HHHHHHHHHHHHCCC		42.9417644757
603UbiquitinationKKIYEIGKNELGDDF
HHHHHHCCCCCCCCC		53.5717644757
648UbiquitinationDLFAPTWKGFLSYLS
HHCCCHHHHHHHHHH		42.1117644757
658UbiquitinationLSYLSWQKPVTAPLP
HHHHHCCCCEECCCC		34.8917644757
680UbiquitinationEGQIGLMKYLGLKNY
CCHHHHHHHHCCCCC		42.2217644757
772UbiquitinationLSIKYKRKLQELDYI
CCCHHHHHHHHCCEE		50.8217644757
831UbiquitinationESNLLSIKFFQSLYE
HHCCHHHHHHHHHHC		36.4317644757
844UbiquitinationYEGTVAQKLMVEEIN
HCCCHHHHHHHEECC		28.9017644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseMDM30Q05930
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
398Kubiquitylation

23317502
464Kubiquitylation

23317502
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FZO1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MGM1_YEASTMGM1physical
12808034
UGO1_YEASTUGO1physical
12808034
UGO1_YEASTUGO1physical
15087460
DNM1_YEASTDNM1genetic
12808034
PDR3_YEASTPDR3genetic
10980204
DNM1_YEASTDNM1genetic
11038180
FIS1_YEASTFIS1genetic
11038183
MDV1_YEASTMDV1genetic
11038183
MDV1_YEASTMDV1genetic
11038182
FIS1_YEASTFIS1genetic
11038182
MDV1_YEASTMDV1genetic
16009724
CAF4_YEASTCAF4genetic
16009724
FZO1_YEASTFZO1physical
16624808
DNM1_YEASTDNM1genetic
11038183
FZO1_YEASTFZO1physical
19812251
MDV1_YEASTMDV1genetic
11038180
MDM30_YEASTMDM30physical
16735578
MDM36_YEASTMDM36genetic
20505073
FZO1_YEASTFZO1physical
21385840
MDM30_YEASTMDM30physical
21385840
SRS2_YEASTSRS2genetic
21459050
MDM30_YEASTMDM30physical
21502136
SSB1_YEASTSSB1physical
22940862
DNM1_YEASTDNM1genetic
19812251
MDM30_YEASTMDM30physical
19812251
PDR1_YEASTPDR1genetic
24807265
PDR3_YEASTPDR3genetic
24807265
MDM30_YEASTMDM30genetic
21502136
MMR1_YEASTMMR1genetic
26764088
PSA3_YEASTPRE9genetic
26552703
RPN4_YEASTRPN4genetic
26552703
SEM1_YEASTSEM1genetic
26552703
PDR5_YEASTPDR5genetic
26552703
CMC1_YEASTSAL1genetic
26552703
MIA40_YEASTMIA40genetic
26552703
CDC48_YEASTCDC48physical
27044889
MGMT_YEASTMGT1genetic
27708008
SGPL_YEASTDPL1genetic
27708008
YHP1_YEASTYHP1genetic
27708008
SHE10_YEASTSHE10genetic
27708008
AIM18_YEASTAIM18genetic
27708008
BCA2_YEASTBAT2genetic
27708008
ACE2_YEASTACE2genetic
27708008
VPS27_YEASTVPS27genetic
27708008
NIP80_YEASTNIP100genetic
27708008
CAB5_YEASTCAB5genetic
27708008
SRPR_YEASTSRP101genetic
27708008
ACT_YEASTACT1genetic
27708008
RCC1_YEASTSRM1genetic
27708008
TEL2_YEASTTEL2genetic
27708008
TIM16_YEASTPAM16genetic
27708008
HSP77_YEASTSSC1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
NNF1_YEASTNNF1genetic
27708008
HYM1_YEASTHYM1genetic
27708008
TIM14_YEASTPAM18genetic
27708008
CDC3_YEASTCDC3genetic
27708008
PROF_YEASTPFY1genetic
27708008
MYO2_YEASTMYO2genetic
27708008
SYLC_YEASTCDC60genetic
27708008
PSB5_YEASTPRE2genetic
27708008
GEM1_YEASTGEM1genetic
27708008
FRM2_YEASTFRM2genetic
27708008
HCM1_YEASTHCM1genetic
27708008
YD218_YEASTYDL218Wgenetic
27708008
UBC13_YEASTUBC13genetic
27708008
YDR09_YEASTYDR109Cgenetic
27708008
NBP2_YEASTNBP2genetic
27708008
INM2_YEASTINM2genetic
27708008
LSM6_YEASTLSM6genetic
27708008
VAM7_YEASTVAM7genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
EFM1_YEASTEFM1genetic
27708008
IGO2_YEASTIGO2genetic
27708008
MPCP_YEASTMIR1genetic
27708008
RL43A_YEASTRPL43Bgenetic
27708008
RL43B_YEASTRPL43Bgenetic
27708008
SFC1_YEASTSFC1genetic
27708008
AIM25_YEASTAIM25genetic
27708008
URA8_YEASTURA8genetic
27708008
ABM1_YEASTABM1genetic
27708008
JHD2_YEASTJHD2genetic
27708008
ENT3_YEASTENT3genetic
27708008
RSF2_YEASTRSF2genetic
27708008
MET7_YEASTSTR2genetic
27708008
XPT1_YEASTXPT1genetic
27708008
MCM22_YEASTMCM22genetic
27708008
MET5_YEASTMET5genetic
27708008
DHOM_YEASTHOM6genetic
27708008
DGR2_YEASTDGR2genetic
27708008
MRP8_YEASTMRP8genetic
27708008
PUR91_YEASTADE16genetic
27708008
CPYI_YEASTTFS1genetic
27708008
UPS1_YEASTUPS1genetic
27708008
BUD6_YEASTBUD6genetic
27708008
PSY3_YEASTPSY3genetic
27708008
SEI1_YEASTFLD1genetic
27708008
YL456_YEASTYLR456Wgenetic
27708008
PML39_YEASTPML39genetic
27708008
YMY9_YEASTYMR099Cgenetic
27708008
PET8_YEASTPET8genetic
27708008
OCA2_YEASTOCA2genetic
27708008
ODP2_YEASTLAT1genetic
27708008
TPM1_YEASTTPM1genetic
27708008
TOM70_YEASTTOM70genetic
27708008
COQ7_YEASTCAT5genetic
27708008
POC4_YEASTPOC4genetic
27708008
RU2A_YEASTLEA1genetic
27708008
YP097_YEASTYPR097Wgenetic
27708008
PIN3_YEASTPIN3genetic
27708008
MMR1_YEASTMMR1genetic
28615194
DNM1_YEASTDNM1genetic
28615194
MYO2_YEASTMYO2genetic
28615194
YPT11_YEASTYPT11genetic
28615194
NUM1_YEASTNUM1genetic
23341591
CDC48_YEASTCDC48physical
29309037
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FZO1_YEAST

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