| UniProt ID | CAF4_YEAST | |
|---|---|---|
| UniProt AC | P36130 | |
| Protein Name | CCR4-associated factor 4 | |
| Gene Name | CAF4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 643 | |
| Subcellular Localization |
Mitochondrion outer membrane Peripheral membrane protein Cytoplasmic side . Uniformly distributed on the cytoplasmic face of the mitochondrial outer membrane. This localization is dependent on FIS1. Reorganizes to punctate structures on mitochond |
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| Protein Description | Involved in mitochondrial fission. Has a partially redundant function to MDV1 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Plays a key role in determining the polarized localization of those DNM1 clusters that are not immediately involved in the mitochondrial fission process.. | |
| Protein Sequence | MGSGDTRGESSLVAKPIEIILNKLPHAILAQQQFQKYITSPIYRYLSKLLLFREVAWPESTKDTQKGQVGIFSFQNNYADSATTFRILAHLDEQRYPLPNGAAEKNLPSLFEGFKATVSIIQQRLLLDNVDGATNSDKEKYVQLPDINTGFVNKTYSRIDLTHLLEDVETNVENLSINKTLEMDELTRLDSMINELESRKLKILERVKHIDSKSTNLENDVTLIKDRINFIEEYNLEADREQSLRKQMEEERSSEASSFTQNEEAISSLCDVESKDTRLKDFYKMPHEKSHDKNRQIISETYSRNTTAFRMTIPHGEHGNSITALDFDTPWGTLCSSSYQDRIVKVWDLNHGIQVGELPGHLATVNCMQIDKKNYNMLITGSKDATLKLWDLNLSREIYLDHSPLKEKTEEIVTPCIHNFELHKDEITALSFDSEALVSGSRDKKIFHWDLTTGKCIQQLDLIFTPTHSDIKMPARSLNNGACLLGTEAPMIGALQCYNSALATGTKDGIVRLWDLRVGKPVRLLEGHTDGITSLKFDSEKLVTGSMDNSVRIWDLRTSSILDVIAYDLPVSSLDFDGKLITVGANEGGVNVFNMERDEHWMTPEPPHSLDGDELSRRIAIVKYKDGFLINGHNDGDINVWTL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 136 | Phosphorylation | NVDGATNSDKEKYVQ CCCCCCCCCHHHEEE | 45.78 | 23749301 | |
| 157 | Phosphorylation | GFVNKTYSRIDLTHL CCCCCEECEEEHHHH | 28.17 | 21440633 | |
| 191 | Phosphorylation | DELTRLDSMINELES HHHHHHHHHHHHHHH | 26.59 | 21440633 | |
| 254 | Phosphorylation | QMEEERSSEASSFTQ HHHHHHHHHHHHHHC | 43.32 | 19779198 | |
| 260 | Phosphorylation | SSEASSFTQNEEAIS HHHHHHHHCCHHHHH | 32.22 | 28889911 | |
| 267 | Phosphorylation | TQNEEAISSLCDVES HCCHHHHHHHCCCCC | 25.06 | 28747907 | |
| 268 | Phosphorylation | QNEEAISSLCDVESK CCHHHHHHHCCCCCC | 27.23 | 19779198 | |
| 274 | Phosphorylation | SSLCDVESKDTRLKD HHHCCCCCCCCCHHH | 35.36 | 19779198 | |
| 395 | Phosphorylation | KLWDLNLSREIYLDH EEEECCCCCEEEECC | 27.13 | 24961812 | |
| 399 | Phosphorylation | LNLSREIYLDHSPLK CCCCCEEEECCCCCC | 11.00 | 19779198 | |
| 403 | Phosphorylation | REIYLDHSPLKEKTE CEEEECCCCCCHHHH | 31.43 | 21440633 | |
| 428 | Phosphorylation | ELHKDEITALSFDSE EECCCEEEEEEECHH | 21.35 | 21440633 | |
| 431 | Phosphorylation | KDEITALSFDSEALV CCEEEEEEECHHHHC | 25.25 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CAF4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CAF4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CAF4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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