MDV1_YEAST - dbPTM
MDV1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MDV1_YEAST
UniProt AC P47025
Protein Name Mitochondrial division protein 1
Gene Name MDV1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 714
Subcellular Localization Mitochondrion outer membrane
Peripheral membrane protein
Cytoplasmic side . Uniformly distributed on the cytoplasmic face of the mitochondrial outer membrane. This localization is dependent on FIS1. Reorganizes to punctate structures on mitochond
Protein Description Involved in mitochondrial fission. Has a partially redundant function to CAF4 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division..
Protein Sequence MSVNDQITHIGKTLSTTASAFLNYQKSNSNTQDVLTNNGPYKNLLSNTVNNASSTSYFYKRTEHGRFVKNASNTFEDIYSKTRRGDVFRNKFTDNKTCFRMLTYISDDLLNEIPTKEGLKSDADGKLLTEGGENENLRKNASKKETSLFQGFKSYLPIAELAIENTERLNYDTNGTSGTVGAKDVMSKTNERDEIHTELPNFQDSFLIPPGVETKKISSSYSPSALKSFSQTLVNSLEFLNIQKNSTLSEIRDIEVEVENLRQKKEKLLGKIANIEQNQLLLEDNLKQIDDRLDFLEEYGLEVIEANSDENAEDDGMSERKALKNDAIRNEGVTTESISSEASNLPPRRRQQLRDDNSLNRLGAFYSKSKKRHRKSFPTFQQLYEPGTKIGSIMSTHDDFLTCLDFDAPFGTLCTAGYLDHTVKIWDLSKQNKIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWNLNLAQQLYQETQNLTSPTNHIDSPCVHTFEAHTDEVTALSLDPSFLVSGSQDRTIRQWDLRSGKCLQTIDLSFANVLTTSTNVDLSKSTLLTQRNERPSIGALQSFDAALATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSLKFDSACLVTGSYDRTVRIWDLRTGLLNKFHAYSAPVLSLDLFQENAAVVVADEPSVQIYDSEKDESWSCVEQGNETSVSTVKYKENYMVEGRENGDVNIWAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSVNDQITH
------CCHHHHHCH		29.6322369663
8PhosphorylationMSVNDQITHIGKTLS
CCHHHHHCHHHHHHH		11.2128889911
15PhosphorylationTHIGKTLSTTASAFL
CHHHHHHHHHHHHHH		29.0124961812
16PhosphorylationHIGKTLSTTASAFLN
HHHHHHHHHHHHHHC		29.5124961812
17PhosphorylationIGKTLSTTASAFLNY
HHHHHHHHHHHHHCC		18.4224961812
19PhosphorylationKTLSTTASAFLNYQK
HHHHHHHHHHHCCCC		19.9124961812
27PhosphorylationAFLNYQKSNSNTQDV
HHHCCCCCCCCCCHH		29.9330377154
46PhosphorylationGPYKNLLSNTVNNAS
CCHHHHHHHHCCCCC		33.3530377154
48PhosphorylationYKNLLSNTVNNASST
HHHHHHHHCCCCCCC		22.6430377154
53PhosphorylationSNTVNNASSTSYFYK
HHHCCCCCCCCEEEE		35.9528889911
55PhosphorylationTVNNASSTSYFYKRT
HCCCCCCCCEEEEEC		25.5828889911
56PhosphorylationVNNASSTSYFYKRTE
CCCCCCCCEEEEECC		18.3930377154
57PhosphorylationNNASSTSYFYKRTEH
CCCCCCCEEEEECCC		15.8330377154
121PhosphorylationPTKEGLKSDADGKLL
CCCCCCCCCCCCCCC		42.9728889911
126UbiquitinationLKSDADGKLLTEGGE
CCCCCCCCCCCCCCC		40.6523749301
219PhosphorylationVETKKISSSYSPSAL
CCCEECCCCCCHHHH		36.4528889911
220PhosphorylationETKKISSSYSPSALK
CCEECCCCCCHHHHH		23.8830377154
222PhosphorylationKKISSSYSPSALKSF
EECCCCCCHHHHHHH		17.8321440633
334PhosphorylationAIRNEGVTTESISSE
HHHCCCCCHHHHCHH		35.3823749301
335PhosphorylationIRNEGVTTESISSEA
HHCCCCCHHHHCHHH		25.9023749301
337PhosphorylationNEGVTTESISSEASN
CCCCCHHHHCHHHHC		26.1923749301
339PhosphorylationGVTTESISSEASNLP
CCCHHHHCHHHHCCC		31.2523749301
340PhosphorylationVTTESISSEASNLPP
CCHHHHCHHHHCCCH		35.2028889911
343PhosphorylationESISSEASNLPPRRR
HHHCHHHHCCCHHHH		34.5423749301
376PhosphorylationSKKRHRKSFPTFQQL
HHHHHHHCCCCHHHH		36.0922369663
379PhosphorylationRHRKSFPTFQQLYEP
HHHHCCCCHHHHCCC		31.8722890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MDV1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MDV1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MDV1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DNM1_YEASTDNM1physical
10688190
DNM1_YEASTDNM1physical
14517324
FIS1_YEASTFIS1physical
12163467
DNM1_YEASTDNM1physical
11179417
DNM1_YEASTDNM1physical
12163467
DNM1_YEASTDNM1physical
11038182
MDV1_YEASTMDV1physical
12163467
FIS1_YEASTFIS1physical
14517324
FIS1_YEASTFIS1physical
16009724
CAF4_YEASTCAF4physical
16009724
MDV1_YEASTMDV1physical
16009724
CAF4_YEASTCAF4genetic
16009724
DNM1_YEASTDNM1physical
16272155
FIS1_YEASTFIS1physical
16247028
MDV1_YEASTMDV1physical
16247028
DNM1_YEASTDNM1physical
16247028
FIS1_YEASTFIS1physical
17884824
FIS1_YEASTFIS1physical
17998537
MDV1_YEASTMDV1physical
19679814
MDV1_YEASTMDV1physical
20444245
FIS1_YEASTFIS1physical
22303011
SWC3_YEASTSWC3physical
22875988
HPH2_YEASTFRT2physical
22875988
NUM1_YEASTNUM1physical
22875988
IVY1_YEASTIVY1physical
22875988
MAD1_YEASTMAD1physical
22875988
CCM1_YEASTCCM1physical
22875988
SKN7_YEASTSKN7physical
22875988
LHS1_YEASTLHS1physical
22875988
CASP_YEASTCOY1physical
22875988
NTR2_YEASTNTR2physical
22875988
SNF7_YEASTSNF7physical
22875988
YL031_YEASTYLR031Wphysical
22875988
YAP8_YEASTARR1physical
22875988
DNM1_YEASTDNM1physical
23148233
DNM1_YEASTDNM1genetic
23530241
FIS1_YEASTFIS1genetic
23530241
CAF4_YEASTCAF4genetic
23530241
MDV1_YEASTMDV1physical
24439911
FIS1_YEASTFIS1physical
24439911
SSN8_YEASTSSN8physical
24439911
CAF4_YEASTCAF4genetic
23810512
TECR_YEASTTSC13genetic
27708008
SNU56_YEASTSNU56genetic
27708008
RMRP_YEASTSNM1genetic
27708008
DBP6_YEASTDBP6genetic
27708008
NUF2_YEASTNUF2genetic
27708008
MGR1_YEASTMGR1genetic
27708008
PCL2_YEASTPCL2genetic
27708008
NUM1_YEASTNUM1genetic
27708008
PAC11_YEASTPAC11genetic
27708008
YIF4_YEASTYIL054Wgenetic
27708008
LDB18_YEASTLDB18genetic
27708008
JNM1_YEASTJNM1genetic
27708008
LIS1_YEASTPAC1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MDV1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53; THR-55; SER-219;SER-340 AND SER-376, AND MASS SPECTROMETRY.

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