| UniProt ID | SKN7_YEAST | |
|---|---|---|
| UniProt AC | P38889 | |
| Protein Name | Transcription factor SKN7 | |
| Gene Name | SKN7 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 622 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.. | |
| Protein Sequence | MSFSTINSNVNKTTGDSNNNTTENSSTADLLGMDLLQSGPRLMNTMQPNNSSDMLHINNKTNNVQQPAGNTNISSANAGAKAPANEFVRKLFRILENNEYPDIVTWTENGKSFVVLDTGKFTTHILPNHFKHSNFASFVRQLNKYDFHKVKRSPEERQRCKYGEQSWEFQHPEFRVHYGKGLDNIKRKIPAQRKVLLDESQKALLHFNSEGTNPNNPSGSLLNESTTELLLSNTVSKDAFGNLRRRVDKLQKELDMSKMESYATKVELQKLNSKYNTVIESLITFKTINENLLNNFNTLCSTLANNGIEVPIFGDNGNRNPTGNTNPATTTAIQSNNNTNNASPATSTVSLQLPNLPDQNSLTPNAQNNTVTLRKGFHVLLVEDDAVSIQLCSKFLRKYGCTVQVVSDGLSAISTLEKYRYDLVLMDIVMPNLDGATATSIVRSFDNETPIIAMTGNIMNQDLITYLQHGMNDILAKPFTRDDLHSILIRYLKDRIPLCEQQLPPRNSSPQTHSNTNTANSNPNTINEQSLAMLPQDNPSTTTPVTPGASISSAQHVQQGQQEQQHQIFHAQQQQQHHNAIANARSDVAIPNLEHEINTVPHSSMGSTPQLPQSTLQENQLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSFSTINSN ------CCCCCCCCC | 28.09 | 28152593 | |
| 4 | Phosphorylation | ----MSFSTINSNVN ----CCCCCCCCCCC | 22.52 | 27717283 | |
| 8 | Phosphorylation | MSFSTINSNVNKTTG CCCCCCCCCCCCCCC | 38.00 | 30377154 | |
| 13 | Phosphorylation | INSNVNKTTGDSNNN CCCCCCCCCCCCCCC | 30.70 | 22369663 | |
| 14 | Phosphorylation | NSNVNKTTGDSNNNT CCCCCCCCCCCCCCC | 40.37 | 22369663 | |
| 17 | Phosphorylation | VNKTTGDSNNNTTEN CCCCCCCCCCCCCCC | 42.68 | 22369663 | |
| 21 | Phosphorylation | TGDSNNNTTENSSTA CCCCCCCCCCCCHHH | 37.30 | 22369663 | |
| 22 | Phosphorylation | GDSNNNTTENSSTAD CCCCCCCCCCCHHHH | 34.98 | 22369663 | |
| 25 | Phosphorylation | NNNTTENSSTADLLG CCCCCCCCHHHHHHC | 23.88 | 22369663 | |
| 26 | Phosphorylation | NNTTENSSTADLLGM CCCCCCCHHHHHHCH | 38.91 | 22369663 | |
| 27 | Phosphorylation | NTTENSSTADLLGMD CCCCCCHHHHHHCHH | 24.82 | 22369663 | |
| 38 | Phosphorylation | LGMDLLQSGPRLMNT HCHHHHHCCCCCCCC | 51.22 | 30377154 | |
| 45 | Phosphorylation | SGPRLMNTMQPNNSS CCCCCCCCCCCCCCC | 11.83 | 22369663 | |
| 51 | Phosphorylation | NTMQPNNSSDMLHIN CCCCCCCCCCCEEEC | 34.06 | 22369663 | |
| 52 | Phosphorylation | TMQPNNSSDMLHINN CCCCCCCCCCEEECC | 29.21 | 22369663 | |
| 61 | Phosphorylation | MLHINNKTNNVQQPA CEEECCCCCCCCCCC | 33.86 | 21440633 | |
| 200 | Phosphorylation | RKVLLDESQKALLHF HEEECCHHHHHHHCC | 36.33 | 30377154 | |
| 273 | Phosphorylation | VELQKLNSKYNTVIE HHHHHHHHHHHHHHH | 47.13 | 27017623 | |
| 418 | Ubiquitination | SAISTLEKYRYDLVL HHHHHHHHHCCCEEE | 37.83 | 22106047 | |
| 427 | Phosphorylation | RYDLVLMDIVMPNLD CCCEEEEEEECCCCC | 26.60 | 9843501 | |
| 607 | Phosphorylation | VPHSSMGSTPQLPQS CCCCCCCCCCCCCHH | 28.42 | 21440633 | |
| 608 | Phosphorylation | PHSSMGSTPQLPQST CCCCCCCCCCCCHHH | 14.88 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SKN7_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SKN7_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SKN7_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-27; SER-51 AND SER-52,AND MASS SPECTROMETRY. | |
