SYIM_YEAST - dbPTM
SYIM_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYIM_YEAST
UniProt AC P48526
Protein Name Isoleucine--tRNA ligase, mitochondrial
Gene Name ISM1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1002
Subcellular Localization Mitochondrion matrix.
Protein Description
Protein Sequence MKRSRLVPQHIFSIISKRYLAKHAYQKTLNLPKTKFPNRSNLEITLRELIPKSSQLVYKEQLRDFFEEFSKLNTTDEKLEFIKEKLFILHDGPPYANGELHLGHALNKILKDIINRYQLSQGKYIFYKPGWDCHGLPIEIKALKDLSAQQIESISPLKIRSMALKHAQKAIKRQRETFQHFAILTDWETPYLTMDKDYEINQLNIFKEMYERGLIKRQNKPVYWGTETRTALAEGELEYNENHKSIAAYVKFPLEKKSQMDLCKKLGITNNLPIYCLIWTSTPWTLLSNRAICFNQDFSYSLLRLNSELILVETGSIDKLGLTTNSFETIKQFQGTHLNGLYYQNLLVDDKVGRPLLHGAHVTSGTGTGLVHTAPGHGQDDYLIGIQNGLEIYSPVDHQGRYQLNELPQSVRSIVRDEGDLTKGRQVLDAETAKIILCKLSDLNLLYKSHEYTHSYPYDWRSKKPVIIRATPQWFADLHDVKNLALESISRVKFCPKRGYSRLSSFMKSRNEWCISRQRSWGIPILSFYKKSEPDSVLMNSEILAHAIEKIKQKGINAWFNDKDNDMKEWLPEKYHDVAHEYCRSQDTMDVWFDSGSSWSVIKDFYEKSLKLSKLPSPLYQVCLEGSDQHRGWFQSSLLTKVASSNVPVAPYEEVITHGFTLDENGLKMSKSVGNTISPEAIIRGDENLGLPALGVDGLRYLIAQSNFTTDIVAGPTVMKHVGEALKKVRLTFRYLLSNLQKSQDFNLLPIEQLRRVDQYTLYKINELLETTREHYQKYNFSKVLITLQYHLNNELSAFYFDISKDILYSNQISSLARRQVQTTLVHILNAYRAILAPILPVMVQEVWKYIPEGWLQGQEHIDINPMRGKWPFLDSNTEIVTSFENFELKILKQFQEEFKRLSLEEGVTKTTHSHVTIFTKHHLPFSSDELCDILQSSAVDILQMDDNNNSLPTIELGSGINVQILVERSKRHNCPRCWKANSAEEDKLCDRCKEAVDHLMS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
189PhosphorylationAILTDWETPYLTMDK
HHEECCCCCCCCCCC		16.9927017623
191PhosphorylationLTDWETPYLTMDKDY
EECCCCCCCCCCCCC		23.4027017623
193PhosphorylationDWETPYLTMDKDYEI
CCCCCCCCCCCCCCH		19.9227017623
701PhosphorylationLGVDGLRYLIAQSNF
CCCCHHHHHHHCCCC		13.9128889911
706PhosphorylationLRYLIAQSNFTTDIV
HHHHHHCCCCCCCCC		25.5328889911
709PhosphorylationLIAQSNFTTDIVAGP
HHHCCCCCCCCCCCH		28.0128889911
710PhosphorylationIAQSNFTTDIVAGPT
HHCCCCCCCCCCCHH		21.4228889911
717PhosphorylationTDIVAGPTVMKHVGE
CCCCCCHHHHHHHHH		32.1128889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYIM_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYIM_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYIM_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MLC1_YEASTMLC1physical
16554755
MYO2_YEASTMYO2physical
16554755
SRS2_YEASTSRS2genetic
21459050
SYIM_YEASTISM1physical
22940862
KTHY_YEASTCDC8genetic
27708008
ETR1_YEASTETR1genetic
27708008
ILM1_YEASTILM1genetic
27708008
STU1_YEASTSTU1genetic
27708008
MAK5_YEASTMAK5genetic
27708008
PRS4_YEASTRPT2genetic
27708008
TIM22_YEASTTIM22genetic
27708008
CAB5_YEASTCAB5genetic
27708008
TSC11_YEASTTSC11genetic
27708008
GNA1_YEASTGNA1genetic
27708008
ACT_YEASTACT1genetic
27708008
CDC14_YEASTCDC14genetic
27708008
PSA1_YEASTSCL1genetic
27708008
PRS8_YEASTRPT6genetic
27708008
RCC1_YEASTSRM1genetic
27708008
TIM44_YEASTTIM44genetic
27708008
ARPC5_YEASTARC15genetic
27708008
CDC11_YEASTCDC11genetic
27708008
CDC16_YEASTCDC16genetic
27708008
CWC16_YEASTYJU2genetic
27708008
HYM1_YEASTHYM1genetic
27708008
CD123_YEASTCDC123genetic
27708008
TAF4_YEASTTAF4genetic
27708008
VTI1_YEASTVTI1genetic
27708008
HRP1_YEASTHRP1genetic
27708008
SYA_YEASTALA1genetic
27708008
GEM1_YEASTGEM1genetic
27708008
PAU8_YEASTPAU8genetic
27708008
PAU11_YEASTPAU8genetic
27708008
PAU9_YEASTPAU8genetic
27708008
OPY1_YEASTOPY1genetic
27708008
AGP2_YEASTAGP2genetic
27708008
MET8_YEASTMET8genetic
27708008
MGR1_YEASTMGR1genetic
27708008
IMG2_YEASTIMG2genetic
27708008
DLD1_YEASTDLD1genetic
27708008
RAD57_YEASTRAD57genetic
27708008
AIM7_YEASTAIM7genetic
27708008
ARO1_YEASTARO1genetic
27708008
DHAS_YEASTHOM2genetic
27708008
UME6_YEASTUME6genetic
27708008
PEX5_YEASTPEX5genetic
27708008
HPRT_YEASTHPT1genetic
27708008
AK_YEASTHOM3genetic
27708008
PP2C2_YEASTPTC2genetic
27708008
ODPA_YEASTPDA1genetic
27708008
MIC19_YEASTMIC19genetic
27708008
MRM2_YEASTMRM2genetic
27708008
AROC_YEASTARO2genetic
27708008
GCN1_YEASTGCN1genetic
27708008
CLG1_YEASTCLG1genetic
27708008
YG1B_YEASTYGR017Wgenetic
27708008
DBF2_YEASTDBF2genetic
27708008
OPI1_YEASTOPI1genetic
27708008
MED20_YEASTSRB2genetic
27708008
PCL7_YEASTPCL7genetic
27708008
FMC1_YEASTFMC1genetic
27708008
RL17B_YEASTRPL17Bgenetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
DHOM_YEASTHOM6genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
IXR1_YEASTIXR1genetic
27708008
PAM17_YEASTPAM17genetic
27708008
ATG10_YEASTATG10genetic
27708008
IZH3_YEASTIZH3genetic
27708008
UPS1_YEASTUPS1genetic
27708008
YL346_YEASTYLR346Cgenetic
27708008
YL415_YEASTYLR415Cgenetic
27708008
ATG23_YEASTATG23genetic
27708008
PALI_YEASTRIM9genetic
27708008
SCS7_YEASTSCS7genetic
27708008
VHS3_YEASTVHS3genetic
27708008
PALA_YEASTRIM20genetic
27708008
SAM4_YEASTSAM4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYIM_YEAST

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Related Literatures of Post-Translational Modification

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