| UniProt ID | HPRT_YEAST | |
|---|---|---|
| UniProt AC | Q04178 | |
| Protein Name | Hypoxanthine-guanine phosphoribosyltransferase | |
| Gene Name | HPT1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 221 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.. | |
| Protein Sequence | MSANDKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPARILRTFLKEPGVPTIRIFAIILSLYEDLNSVGSEVEEVGVKVSRTQWIDYEQCKLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFIPEQEHKQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSANDKQYI ------CCCCHHCEE | 35.46 | 22814378 | |
| 6 | Acetylation | --MSANDKQYISYNN --CCCCHHCEECCCC | 44.82 | 24489116 | |
| 29 | Ubiquitination | AERIKNFKPDLIIAI HHHHHHCCCCEEEEE | 47.19 | 22106047 | |
| 52 | Acetylation | RILRTFLKEPGVPTI HHHHHHHCCCCCCHH | 58.64 | 24489116 | |
| 52 | Succinylation | RILRTFLKEPGVPTI HHHHHHHCCCCCCHH | 58.64 | 23954790 | |
| 98 | Acetylation | WIDYEQCKLDLVGKN EECHHHCCEEECCCC | 44.74 | 24489116 | |
| 128 | Acetylation | YALSELEKDAAEQAK HHHHHHHHHHHHHHH | 66.35 | 24489116 | |
| 141 | Phosphorylation | AKAKGIDTEKSPEMK HHHCCCCCCCCHHHH | 43.31 | 27017623 | |
| 143 | Ubiquitination | AKGIDTEKSPEMKTN HCCCCCCCCHHHHCC | 73.69 | 23749301 | |
| 144 | Phosphorylation | KGIDTEKSPEMKTNF CCCCCCCCHHHHCCE | 21.62 | 23749301 | |
| 175 | Acetylation | PAEMLNDKNRYFAAK CHHHCCCCCCEEEEE | 42.10 | 24489116 | |
| 182 | Acetylation | KNRYFAAKTVPDKWY CCCEEEEEECCCCCE | 46.77 | 24489116 | |
| 220 | Acetylation | FIPEQEHKQ------ CCCHHHCCC------ | 57.88 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HPRT_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HPRT_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HPRT_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
