PUR4_YEAST - dbPTM
PUR4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PUR4_YEAST
UniProt AC P38972
Protein Name Phosphoribosylformylglycinamidine synthase
Gene Name ADE6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1358
Subcellular Localization Cytoplasm.
Protein Description Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity)..
Protein Sequence MTDYILPGPKALSQFRVDNLIKDINSYTNSTSVINELRSCYIHYVNGIAQNLSEQDTKLLEVLLTYDSALDIANDPLARQLNDAVANNLPSSALGEDTYLIRVVPRSGTISPWSSKATNIAHVCGLQDKVQRIERGLALLIKTVPGFPLLENLNDISLKCVYDRMTQQLYLTEPPNTMSIFTHEEPKPLVHVPLTPKDTKQSPKDILSKANTELGLALDSGEMEYLIHAFVETMKRDPTDVELFMFAQVNSEHCRHKIFNADWTIDGIKQQFTLFQMIRNTHKLNPEYTISAYSDNAAVLDSENDAFFFAPNSTTKEWTSTKERIPLLIKVETHNHPTAVSPFPGAATGSGGEIRDEGATGRGSKTKCGLSGFSVSDLLIPGNEQPWELNIGKPYHIASALDIMIEAPLGSAAFNNEFGRPCINGYFRTLTTKVLNHQGKEEIRGFHKPIMIAGGFGTVRPQFALKNTPITPGSCLIVLGGQSMLIGLGGGAASSVASGEGSADLDFASVQRGNPEMERRCQQVIDACVALGNNNPIQSIHDVGAGGLSNALPELVHDNDLGAKFDIRKVLSLEPGMSPMEIWCNESQERYVLGVSPQDLSIFEEICKRERAPFAVVGHATAEQKLIVEDPLLKTTPIDLEMPILFGKPPKMSRETITEALNLPEANLSEIPSLQDAIQRVLNLPSVGSKSFLITIGDRSVTGLIDRDQFVGPWQVPVADVGVTGTSLGETIISTGEAMAMGEKPVNALISASASAKLSVAESLLNIFAADVKSLNHIKLSANWMSPASHQGEGSKLYEAVQALGLDLCPALGVAIPVGKDSMSMKMKWDDKEVTAPLSLNITAFAPVFNTSKTWTPLLNRNTDDSVLVLVDLSAKQETKSLGASALLQVYNQVGNKSPTVYDNAILKGFLESLIQLHQQKEDIVLAYHDRSDGGLLITLLEMAFASRCGLEINIDGGDLESQLTNLFNEELGAVFQISAKNLSKFEKILNENGVAKEYISIVGKPSFQSQEIKIINSTTNDVIYANSRSELEQTWSKTSYEMQKLRDNPKTAEEEFASITDDRDPGLQYALTYNPADDMKIGLELSSQRPKVAILREQGVNGQMEMAWCFQQAGFNSVDVTMTDLLEGRFHLDDFIGLAACGGFSYGDVLGAGAGWAKSVLYHEGVRSQFSKFFNERQDTFAFGACNGCQFLSRLKDIIPGCENWPSFERNVSEQYEARVCMVQISQEKDNSSEESVFLNGMAGSKLPIAVAHGEGKATFSKSAEQLEKFEKDGLCCIRYVDNYGNVTERFPFNPNGSTNGIAGIKSPNGRVLAMMPHPERVCRLEANSWYPEGKYEEWGGYGPWIRLFRSARRWVG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MTDYILPGP
------CCCCCCCCH		49.1422814378
10UbiquitinationDYILPGPKALSQFRV
CCCCCCHHHHHHHCH		68.8024961812
13PhosphorylationLPGPKALSQFRVDNL
CCCHHHHHHHCHHHH		31.9421440633
22UbiquitinationFRVDNLIKDINSYTN
HCHHHHHHHHHHCCC		56.5824961812
107PhosphorylationLIRVVPRSGTISPWS
EEEEECCCCCCCCCC		33.9322369663
109PhosphorylationRVVPRSGTISPWSSK
EEECCCCCCCCCCCC		21.3822369663
111PhosphorylationVPRSGTISPWSSKAT
ECCCCCCCCCCCCCH		21.8322369663
114PhosphorylationSGTISPWSSKATNIA
CCCCCCCCCCCHHHH		25.9122369663
115PhosphorylationGTISPWSSKATNIAH
CCCCCCCCCCHHHHH		23.5722369663
116UbiquitinationTISPWSSKATNIAHV
CCCCCCCCCHHHHHH		54.4323749301
129UbiquitinationHVCGLQDKVQRIERG
HHCCCHHHHHHHHHH		27.5717644757
129AcetylationHVCGLQDKVQRIERG
HHCCCHHHHHHHHHH		27.5724489116
195PhosphorylationPLVHVPLTPKDTKQS
CCEECCCCCCCCCCC		23.4029734811
257AcetylationNSEHCRHKIFNADWT
CCHHHCCHHHCCCCC		29.6424489116
257UbiquitinationNSEHCRHKIFNADWT
CCHHHCCHHHCCCCC		29.6423749301
330AcetylationERIPLLIKVETHNHP
CCCCEEEEEEECCCC		33.7124489116
333PhosphorylationPLLIKVETHNHPTAV
CEEEEEEECCCCCCC		30.8529136822
338PhosphorylationVETHNHPTAVSPFPG
EEECCCCCCCCCCCC		31.9429136822
341PhosphorylationHNHPTAVSPFPGAAT
CCCCCCCCCCCCCCC		20.5429136822
360PhosphorylationEIRDEGATGRGSKTK
EECCCCCCCCCCCCC		37.9628889911
364PhosphorylationEGATGRGSKTKCGLS
CCCCCCCCCCCCCCC		35.4728889911
433UbiquitinationYFRTLTTKVLNHQGK
HHHHHHHHHHCCCCH		39.2222817900
440AcetylationKVLNHQGKEEIRGFH
HHHCCCCHHHHCCCC		45.6722865919
448UbiquitinationEEIRGFHKPIMIAGG
HHHCCCCCCEEEECC		33.7022817900
448AcetylationEEIRGFHKPIMIAGG
HHHCCCCCCEEEECC		33.7024489116
578PhosphorylationLSLEPGMSPMEIWCN
HCCCCCCCCCEEEEC		27.3228152593
596PhosphorylationERYVLGVSPQDLSIF
CEEECCCCHHHHHHH		18.2922369663
625UbiquitinationGHATAEQKLIVEDPL
CCCCHHCEEEECCCC		31.5217644757
634UbiquitinationIVEDPLLKTTPIDLE
EECCCCCCCCCCCCC		59.0217644757
648AcetylationEMPILFGKPPKMSRE
CCCHHCCCCCCCCHH		51.3024489116
648UbiquitinationEMPILFGKPPKMSRE
CCCHHCCCCCCCCHH		51.3017644757
651UbiquitinationILFGKPPKMSRETIT
HHCCCCCCCCHHHHH		59.0217644757
757UbiquitinationISASASAKLSVAESL
HHCCHHHCHHHHHHH		38.5117644757
773UbiquitinationNIFAADVKSLNHIKL
HHHHHCHHHCCCEEE		50.1817644757
786PhosphorylationKLSANWMSPASHQGE
EEEECCCCCCCCCCC		14.6623749301
822PhosphorylationAIPVGKDSMSMKMKW
EEECCCCCCCCEECC		19.0827017623
824PhosphorylationPVGKDSMSMKMKWDD
ECCCCCCCCEECCCC		21.1427017623
835PhosphorylationKWDDKEVTAPLSLNI
CCCCCCCCCCEEEEE		24.5322369663
839PhosphorylationKEVTAPLSLNITAFA
CCCCCCEEEEEEEEE		20.5022369663
843PhosphorylationAPLSLNITAFAPVFN
CCEEEEEEEEECCCC		18.0422369663
851PhosphorylationAFAPVFNTSKTWTPL
EEECCCCCCCCCCCC		21.8222369663
852PhosphorylationFAPVFNTSKTWTPLL
EECCCCCCCCCCCCC		29.2322369663
854PhosphorylationPVFNTSKTWTPLLNR
CCCCCCCCCCCCCCC		34.0522369663
856PhosphorylationFNTSKTWTPLLNRNT
CCCCCCCCCCCCCCC		14.8622369663
880UbiquitinationLSAKQETKSLGASAL
CCCCHHHHCCCHHHH		42.8217644757
897UbiquitinationVYNQVGNKSPTVYDN
HHHHHCCCCCCHHHH		52.4617644757
921AcetylationLIQLHQQKEDIVLAY
HHHHHHCCCCEEEEE		51.2724489116
985AcetylationISAKNLSKFEKILNE
EECCCHHHHHHHHCC		61.7924489116
988AcetylationKNLSKFEKILNENGV
CCHHHHHHHHCCCCC		56.4724489116
1038UbiquitinationELEQTWSKTSYEMQK
HHHHHHHHHHHHHHH		32.8123749301
1081UbiquitinationYNPADDMKIGLELSS
ECCHHHCEEEEEECC		40.3919722269
1160PhosphorylationAGAGWAKSVLYHEGV
CCCCCHHHHHHHHHH		15.0321440633
11732-HydroxyisobutyrylationGVRSQFSKFFNERQD
HHHHHHHHHHHHCCC		56.09-
1173AcetylationGVRSQFSKFFNERQD
HHHHHHHHHHHHCCC		56.0924489116
1197UbiquitinationCQFLSRLKDIIPGCE
HHHHHHHHHHCCCCC		45.8522817900
1237PhosphorylationKDNSSEESVFLNGMA
CCCCCCCEEECCCCC		17.7027017623
1246PhosphorylationFLNGMAGSKLPIAVA
ECCCCCCCCCCEEEE		22.8327017623
1247UbiquitinationLNGMAGSKLPIAVAH
CCCCCCCCCCEEEEE		58.3224961812
1258UbiquitinationAVAHGEGKATFSKSA
EEEECCCEECCCCCH		39.6922817900
1263AcetylationEGKATFSKSAEQLEK
CCEECCCCCHHHHHH		49.8724489116
1263UbiquitinationEGKATFSKSAEQLEK
CCEECCCCCHHHHHH		49.8722817900
12632-HydroxyisobutyrylationEGKATFSKSAEQLEK
CCEECCCCCHHHHHH		49.87-
1307UbiquitinationTNGIAGIKSPNGRVL
CCCCCCCCCCCCCEE		59.9723749301
1336UbiquitinationNSWYPEGKYEEWGGY
CCCCCCCCCCCCCCC		48.0723749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PUR4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PUR4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PUR4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VAC14_YEASTVAC14physical
10688190
VAC14_YEASTVAC14physical
18719252
VAM6_YEASTVAM6genetic
20093466
SLX5_YEASTSLX5genetic
20093466
VPS41_YEASTVPS41genetic
20093466
HPRT_YEASTHPT1genetic
20093466
FCY2_YEASTFCY2genetic
20093466
PT122_YEASTPET122genetic
20093466
VAM7_YEASTVAM7genetic
20093466
PHB2_YEASTPHB2genetic
20093466
LST4_YEASTLST4genetic
20093466
PCKA_YEASTPCK1genetic
20093466
RL37A_YEASTRPL37Agenetic
20093466
VPS9_YEASTVPS9genetic
20093466
YPT7_YEASTYPT7genetic
20093466
YM79_YEASTYMR244Wgenetic
20093466
SWS2_YEASTSWS2genetic
20093466
COX5A_YEASTCOX5Agenetic
20093466
PHO80_YEASTPHO80genetic
20093466
VAM3_YEASTVAM3genetic
20093466
COQ7_YEASTCAT5genetic
20093466
RU2A_YEASTLEA1genetic
20093466
POC4_YEASTPOC4genetic
20093466
PMA2_YEASTPMA2genetic
20093466
CHMU_YEASTARO7genetic
20093466
HPRT_YEASTHPT1genetic
21623372
FOLE_YEASTMET7genetic
21623372
FCY2_YEASTFCY2genetic
21623372
INV2_YEASTSUC2genetic
21623372
ACON2_YEASTACO2genetic
21623372
ATP5E_YEASTATP15genetic
21623372
PUR7_YEASTADE1genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
ELO2_YEASTELO2genetic
21623372
ADH3_YEASTADH3genetic
21623372
COX5A_YEASTCOX5Agenetic
27708008
MSS18_YEASTMSS18genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
RV161_YEASTRVS161genetic
27708008
IMG2_YEASTIMG2genetic
27708008
SLX5_YEASTSLX5genetic
27708008
GPR1_YEASTGPR1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
VMS1_YEASTVMS1genetic
27708008
RM01_YEASTMRPL1genetic
27708008
ARO1_YEASTARO1genetic
27708008
BCS1_YEASTBCS1genetic
27708008
HPRT_YEASTHPT1genetic
27708008
IRC4_YEASTIRC4genetic
27708008
FCY2_YEASTFCY2genetic
27708008
MRM2_YEASTMRM2genetic
27708008
ATG1_YEASTATG1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
COX23_YEASTCOX23genetic
27708008
VPS35_YEASTVPS35genetic
27708008
MDM35_YEASTMDM35genetic
27708008
EF1G2_YEASTTEF4genetic
27708008
LST4_YEASTLST4genetic
27708008
CBT1_YEASTCBT1genetic
27708008
PCKA_YEASTPCK1genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
YPT7_YEASTYPT7genetic
27708008
VPS9_YEASTVPS9genetic
27708008
PKR1_YEASTPKR1genetic
27708008
YM79_YEASTYMR244Wgenetic
27708008
PET8_YEASTPET8genetic
27708008
SWS2_YEASTSWS2genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
PHO80_YEASTPHO80genetic
27708008
ASE1_YEASTASE1genetic
27708008
CY1_YEASTCYT1genetic
27708008
COQ7_YEASTCAT5genetic
27708008
PMA2_YEASTPMA2genetic
27708008
FRK1_YEASTFRK1genetic
27708008
AIM44_YEASTAIM44genetic
27708008
CHMU_YEASTARO7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PUR4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-333, AND MASSSPECTROMETRY.

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