PCKA_YEAST - dbPTM
PCKA_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCKA_YEAST
UniProt AC P10963
Protein Name Phosphoenolpyruvate carboxykinase (ATP)
Gene Name PCK1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 549
Subcellular Localization
Protein Description
Protein Sequence MSPSKMNATVGSTSEVEQKIRQELALSDEVTTIRRNAPAAVLYEDGLKENKTVISSSGALIAYSGVKTGRSPKDKRIVEEPTSKDEIWWGPVNKPCSERTWSINRERAADYLRTRDHIYIVDAFAGWDPKYRIKVRVVCARAYHALFMTNMLIRPTEEELAHFGEPDFTVWNAGQFPANLHTQDMSSKSTIEINFKAMEMIILGTEYAGEMKKGIFTVMFYLMPVHHNVLTLHSSANQGIQNGDVTLFFGLSGTGKTTLSADPHRLLIGDDEHCWSDHGVFNIEGGCYAKCINLSAEKEPEIFDAIKFGSVLENVIYDEKSHVVDYDDSSITENTRCAYPIDYIPSAKIPCLADSHPKNIILLTCDASGVLPPVSKLTPEQVMYHFISGYTSKMAGTEQGVTEPEPTFSSCFGQPFLALHPIRYATMLATKMSQHKANAYLINTGWTGSSYVSGGKRCPLKYTRAILDSIHDGSLANETYETLPIFNLQVPTKVNGVPAELLNPAKNWSQGESKYRGAVTNLANLFVQNFKIYQDRATPDVLAAGPQFE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationKMNATVGSTSEVEQK
HCCCCCCCHHHHHHH		25.1530377154
13PhosphorylationMNATVGSTSEVEQKI
CCCCCCCHHHHHHHH		23.9930377154
14PhosphorylationNATVGSTSEVEQKIR
CCCCCCHHHHHHHHH		41.1430377154
19AcetylationSTSEVEQKIRQELAL
CHHHHHHHHHHHHCC		26.7619303850
482-HydroxyisobutyrylationVLYEDGLKENKTVIS
EEECCCCCCCCEEEC		65.84-
52PhosphorylationDGLKENKTVISSSGA
CCCCCCCEEECCCCC		34.3522890988
55PhosphorylationKENKTVISSSGALIA
CCCCEEECCCCCEEE		17.7022890988
56PhosphorylationENKTVISSSGALIAY
CCCEEECCCCCEEEE		22.9722890988
57PhosphorylationNKTVISSSGALIAYS
CCEEECCCCCEEEEC		22.6922890988
63PhosphorylationSSGALIAYSGVKTGR
CCCCEEEECCCCCCC		10.0422890988
64PhosphorylationSGALIAYSGVKTGRS
CCCEEEECCCCCCCC		28.2522890988
329PhosphorylationHVVDYDDSSITENTR
CEECCCCCCCCCCCE		22.2727214570
330PhosphorylationVVDYDDSSITENTRC
EECCCCCCCCCCCEE		40.2925005228
332PhosphorylationDYDDSSITENTRCAY
CCCCCCCCCCCEEEC		25.7325371407
424PhosphorylationLALHPIRYATMLATK
HHHHHHHHHHHHHHH		13.7228889911
426PhosphorylationLHPIRYATMLATKMS
HHHHHHHHHHHHHHH		12.0928889911
514AcetylationNWSQGESKYRGAVTN
CCCCCCHHHHHHHHH		34.3625381059
538PhosphorylationKIYQDRATPDVLAAG
CCCCCCCCHHHHCCC		22.4029734811
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCKA_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCKA_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCKA_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PCKA_YEASTPCK1physical
18467557
ALO_YEASTALO1physical
18467557
PCKA_YEASTPCK1physical
18719252
CG13_YEASTCLN3genetic
19269370
INP52_YEASTINP52genetic
19269370
YCY0_YEASTYCR090Cgenetic
20093466
DTD_YEASTDTD1genetic
20093466
MGMT_YEASTMGT1genetic
20093466
ATG9_YEASTATG9genetic
20093466
RLA1_YEASTRPP1Agenetic
20093466
RMD5_YEASTRMD5genetic
20093466
DSE1_YEASTDSE1genetic
20093466
IOC3_YEASTIOC3genetic
20093466
YGY5_YEASTYGL235Wgenetic
20093466
MED5_YEASTNUT1genetic
20093466
YG036_YEASTYGL036Wgenetic
20093466
PUR4_YEASTADE6genetic
20093466
PCP1_YEASTPCP1genetic
20093466
VMA21_YEASTVMA21genetic
20093466
PSA3_YEASTPRE9genetic
20093466
NPR3_YEASTNPR3genetic
20093466
HTD2_YEASTHTD2genetic
20093466
LRP1_YEASTLRP1genetic
20093466
STB5_YEASTSTB5genetic
20093466
FYV10_YEASTFYV10genetic
20093466
MNR2_YEASTMNR2genetic
20093466
ATG10_YEASTATG10genetic
20093466
EMC6_YEASTEMC6genetic
20093466
PUF3_YEASTPUF3genetic
20093466
SWI6_YEASTSWI6genetic
20093466
LIPB_YEASTLIP2genetic
20093466
VRP1_YEASTVRP1genetic
20093466
VID22_YEASTVID22genetic
20093466
ERG2_YEASTERG2genetic
20093466
ZRC1_YEASTZRC1genetic
20093466
TRM11_YEASTTRM11genetic
20093466
MSN1_YEASTMSN1genetic
20093466
SDHF2_YEASTSDH5genetic
20093466
BUD21_YEASTBUD21genetic
20093466
GSP2_YEASTGSP2genetic
20093466
LIPA_YEASTLIP5genetic
20093466
VPH1_YEASTVPH1genetic
20093466
YME1_YEASTYME1genetic
20093466
TOR1_YEASTTOR1physical
20457600
KOG1_YEASTKOG1physical
20457600
LST8_YEASTLST8physical
20457600
COX5A_YEASTCOX5Agenetic
21623372
ADH3_YEASTADH3genetic
21623372
CEM1_YEASTCEM1genetic
21623372
COQ4_YEASTCOQ4genetic
21623372
GSH1_YEASTGSH1genetic
21623372
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCKA_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330, AND MASSSPECTROMETRY.

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