| UniProt ID | IOC3_YEAST | |
|---|---|---|
| UniProt AC | P43596 | |
| Protein Name | ISWI one complex protein 3 | |
| Gene Name | IOC3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 787 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Functions as component of the ISW1A complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1A complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome.. | |
| Protein Sequence | MDSPSNSIQNLQQEAQGSSSAQLADHDHDRVSMAMPLQTDQSVSVSQSSDNLRRSRRVPKPRTSIYDEYEEELKERANKPKRKRPAPPKKKAPSTQNSKSNDKVEKKKTTSIAKDGKPTLKTNDKKVAPKPKPAHEQVEPALIPSNWTSVIPLLTSDFKNQYSVISRLKNPNMKPVPYAGDIIKLMAFINKFSSFFHSDLQNLSFQDFEVGLDLYPGDPNGSAAGIVKGPEDTSLLLYPDFMAIKDIVYCQDKMNLLFLSLLDLTFTENFDGKSAKKKGPLTTWENLKSSSKKVFSNPLYRLRLVAREWGYPREWRQQLPSDQDISKPKTALFEQDEQTPVVDPSHPEILTPNIYTWNANEPLPLESNPLYNREMDKNGILALKPMDRVVLLRALTDWCASHSSAIHDEIYKLTHGKKDPVFGIQTQQVPRYTIEGVDNTINQFKKLCSLIQSRYEIRSKKKHFVKQLKEGKKPDLSRKLEILKEIKAELKNAVKSEKDELLFSLYDKWVPLFEGELPDQPLANPFSERLYKLRLQEFFLGRVPHIGDFYMPRLHSYGDSLEMSTFTDLRNLQALLSKFKNNEYNAFTLFENDGQSMSAQFKLFYHDTPSLAHDVARGRNTSGKVYWYELCHDSATLLEFLEFLDYKIVKPQDEKKEGNEKEKEALNNEAHILEQKSTTDNNPSINTNPLPKDAKYNTARKKLQILKEFLSDYYFILRQFEQMKVQFADMKPGKRQLRRIQRQTVNYNTEYDSEEYVDDEEDDEADIYDDNDNDSSFDDGRVKRQRT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MDSPSNSIQN -----CCCCCHHHHH | 29.00 | 22369663 | |
| 5 | Phosphorylation | ---MDSPSNSIQNLQ ---CCCCCHHHHHHH | 47.35 | 28132839 | |
| 7 | Phosphorylation | -MDSPSNSIQNLQQE -CCCCCHHHHHHHHH | 29.86 | 22369663 | |
| 18 | Phosphorylation | LQQEAQGSSSAQLAD HHHHHCCCCCHHHCC | 14.72 | 22369663 | |
| 19 | Phosphorylation | QQEAQGSSSAQLADH HHHHCCCCCHHHCCC | 36.20 | 22369663 | |
| 20 | Phosphorylation | QEAQGSSSAQLADHD HHHCCCCCHHHCCCC | 23.02 | 22369663 | |
| 39 | Phosphorylation | SMAMPLQTDQSVSVS EEECCCCCCCCEECC | 43.63 | 22369663 | |
| 42 | Phosphorylation | MPLQTDQSVSVSQSS CCCCCCCCEECCCCC | 21.12 | 22369663 | |
| 44 | Phosphorylation | LQTDQSVSVSQSSDN CCCCCCEECCCCCHH | 22.69 | 22369663 | |
| 46 | Phosphorylation | TDQSVSVSQSSDNLR CCCCEECCCCCHHHH | 19.48 | 22369663 | |
| 48 | Phosphorylation | QSVSVSQSSDNLRRS CCEECCCCCHHHHHC | 31.95 | 27214570 | |
| 49 | Phosphorylation | SVSVSQSSDNLRRSR CEECCCCCHHHHHCC | 23.92 | 22369663 | |
| 114 | Acetylation | KKTTSIAKDGKPTLK HHHHHCCCCCCCCCC | 66.40 | 22865919 | |
| 293 | Ubiquitination | NLKSSSKKVFSNPLY HHHHCCCCHHCCHHH | 50.92 | 22106047 | |
| 377 | Acetylation | LYNREMDKNGILALK CCCCCCCCCCCEEEC | 56.62 | 25381059 | |
| 384 | Acetylation | KNGILALKPMDRVVL CCCCEEECCCCHHHH | 32.46 | 25381059 | |
| 577 | Phosphorylation | RNLQALLSKFKNNEY HHHHHHHHHHCCCCC | 36.58 | 29734811 | |
| 677 | Phosphorylation | AHILEQKSTTDNNPS HHHHHHCCCCCCCCC | 35.91 | 30377154 | |
| 687 | Phosphorylation | DNNPSINTNPLPKDA CCCCCCCCCCCCCCC | 36.22 | 25521595 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IOC3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IOC3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IOC3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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