UniProt ID | PUF3_YEAST | |
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UniProt AC | Q07807 | |
Protein Name | mRNA-binding protein PUF3 | |
Gene Name | PUF3 | |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
Sequence Length | 879 | |
Subcellular Localization |
Mitochondrion outer membrane Peripheral membrane protein Cytoplasmic side. Cytoplasm. Localizes to multiple discrete foci in the cytoplasm. |
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Protein Description | RNA-binding protein involved in post-transcriptional regulation. Negatively regulates expression of COX17 by binding to the 3'-UTR of COX17 mRNA. Promotes decay of COX17 mRNA by enhancing its rate of deadenylation and subsequent turnover. Predominantly binds to mRNAs encoding mitochondrial proteins and localizes them to the vicinity of mitochondria for translation. Regulates mitochondrial biogenesis, motility and morphology.. | |
Protein Sequence | MEMNMDMDMDMELASIVSSLSALSHSNNNGGQAAAAGIVNGGAAGSQQIGGFRRSSFTTANEVDSEILLLHGSSESSPIFKKTALSVGTAPPFSTNSKKFFGNGGNYYQYRSTDTASLSSASYNNYHTHHTAANLGKNNKVNHLLGQYSASIAGPVYYNGNDNNNSGGEGFFEKFGKSLIDGTRELESQDRPDAVNTQSQFISKSVSNASLDTQNTFEQNVESDKNFNKLNRNTTNSGSLYHSSSNSGSSASLESENAHYPKRNIWNVANTPVFRPSNNPAAVGATNVALPNQQDGPANNNFPPYMNGFPPNQFHQGPHYQNFPNYLIGSPSNFISQMISVQIPANEDTEDSNGKKKKKANRPSSVSSPSSPPNNSPFPFAYPNPMMFMPPPPLSAPQQQQQQQQQQQQEDQQQQQQQENPYIYYPTPNPIPVKMPKDEKTFKKRNNKNHPANNSNNANKQANPYLENSIPTKNTSKKNASSKSNESTANNHKSHSHSHPHSQSLQQQQQTYHRSPLLEQLRNSSSDKNSNSNMSLKDIFGHSLEFCKDQHGSRFIQRELATSPASEKEVIFNEIRDDAIELSNDVFGNYVIQKFFEFGSKIQKNTLVDQFKGNMKQLSLQMYACRVIQKALEYIDSNQRIELVLELSDSVLQMIKDQNGNHVIQKAIETIPIEKLPFILSSLTGHIYHLSTHSYGCRVIQRLLEFGSSEDQESILNELKDFIPYLIQDQYGNYVIQYVLQQDQFTNKEMVDIKQEIIETVANNVVEYSKHKFASNVVEKSILYGSKNQKDLIISKILPRDKNHALNLEDDSPMILMIKDQFANYVIQKLVNVSEGEGKKLIVIAIRAYLDKLNKSNSLGNRHLASVEKLAALVENAEV | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
55 | Phosphorylation | QIGGFRRSSFTTANE CCCCCCCCCCCCCCC | 26.08 | 22369663 | |
56 | Phosphorylation | IGGFRRSSFTTANEV CCCCCCCCCCCCCCC | 25.46 | 19779198 | |
58 | Phosphorylation | GFRRSSFTTANEVDS CCCCCCCCCCCCCCC | 27.26 | 22369663 | |
59 | Phosphorylation | FRRSSFTTANEVDSE CCCCCCCCCCCCCCE | 26.02 | 19779198 | |
65 | Phosphorylation | TTANEVDSEILLLHG CCCCCCCCEEEHHHC | 31.54 | 22369663 | |
73 | Phosphorylation | EILLLHGSSESSPIF EEEHHHCCCCCCCCC | 21.86 | 22369663 | |
74 | Phosphorylation | ILLLHGSSESSPIFK EEHHHCCCCCCCCCC | 46.20 | 22369663 | |
76 | Phosphorylation | LLHGSSESSPIFKKT HHHCCCCCCCCCCHH | 43.28 | 21440633 | |
77 | Phosphorylation | LHGSSESSPIFKKTA HHCCCCCCCCCCHHC | 20.26 | 22369663 | |
83 | Phosphorylation | SSPIFKKTALSVGTA CCCCCCHHCCCCCCC | 33.16 | 25521595 | |
86 | Phosphorylation | IFKKTALSVGTAPPF CCCHHCCCCCCCCCC | 18.94 | 22369663 | |
89 | Phosphorylation | KTALSVGTAPPFSTN HHCCCCCCCCCCCCC | 33.56 | 22369663 | |
94 | Phosphorylation | VGTAPPFSTNSKKFF CCCCCCCCCCCCCCC | 32.24 | 22890988 | |
95 | Phosphorylation | GTAPPFSTNSKKFFG CCCCCCCCCCCCCCC | 43.84 | 22890988 | |
97 | Phosphorylation | APPFSTNSKKFFGNG CCCCCCCCCCCCCCC | 36.99 | 22890988 | |
98 | Ubiquitination | PPFSTNSKKFFGNGG CCCCCCCCCCCCCCC | 56.52 | 17644757 | |
99 | Ubiquitination | PFSTNSKKFFGNGGN CCCCCCCCCCCCCCC | 45.83 | 17644757 | |
112 | Phosphorylation | GNYYQYRSTDTASLS CCCEEEEECCCCCCC | 26.21 | 22369663 | |
113 | Phosphorylation | NYYQYRSTDTASLSS CCEEEEECCCCCCCC | 28.50 | 22369663 | |
115 | Phosphorylation | YQYRSTDTASLSSAS EEEEECCCCCCCCCC | 20.45 | 22369663 | |
117 | Phosphorylation | YRSTDTASLSSASYN EEECCCCCCCCCCCC | 30.77 | 22369663 | |
119 | Phosphorylation | STDTASLSSASYNNY ECCCCCCCCCCCCCC | 22.74 | 22369663 | |
120 | Phosphorylation | TDTASLSSASYNNYH CCCCCCCCCCCCCCC | 26.91 | 22369663 | |
122 | Phosphorylation | TASLSSASYNNYHTH CCCCCCCCCCCCCCC | 30.27 | 22369663 | |
123 | Phosphorylation | ASLSSASYNNYHTHH CCCCCCCCCCCCCCC | 13.72 | 22369663 | |
126 | Phosphorylation | SSASYNNYHTHHTAA CCCCCCCCCCCCCCH | 12.40 | 22369663 | |
128 | Phosphorylation | ASYNNYHTHHTAANL CCCCCCCCCCCCHHH | 12.65 | 21440633 | |
131 | Phosphorylation | NNYHTHHTAANLGKN CCCCCCCCCHHHCCC | 21.62 | 22369663 | |
137 | Ubiquitination | HTAANLGKNNKVNHL CCCHHHCCCHHHHHH | 61.59 | 17644757 | |
148 | Phosphorylation | VNHLLGQYSASIAGP HHHHHHCCCCCCCCC | 12.38 | 21440633 | |
149 | Phosphorylation | NHLLGQYSASIAGPV HHHHHCCCCCCCCCE | 13.98 | 22369663 | |
151 | Phosphorylation | LLGQYSASIAGPVYY HHHCCCCCCCCCEEE | 13.66 | 20377248 | |
157 | Phosphorylation | ASIAGPVYYNGNDNN CCCCCCEEECCCCCC | 8.37 | 22369663 | |
158 | Phosphorylation | SIAGPVYYNGNDNNN CCCCCEEECCCCCCC | 19.48 | 21440633 | |
166 | Phosphorylation | NGNDNNNSGGEGFFE CCCCCCCCCCCCHHH | 50.74 | 22369663 | |
178 | Phosphorylation | FFEKFGKSLIDGTRE HHHHHHHHHCCCCCH | 30.82 | 28889911 | |
188 | Phosphorylation | DGTRELESQDRPDAV CCCCHHHHCCCCCCC | 50.43 | 19779198 | |
197 | Phosphorylation | DRPDAVNTQSQFISK CCCCCCHHHHHHHHH | 24.01 | 22369663 | |
199 | Phosphorylation | PDAVNTQSQFISKSV CCCCHHHHHHHHHHH | 25.64 | 20377248 | |
203 | Phosphorylation | NTQSQFISKSVSNAS HHHHHHHHHHHHCCC | 21.84 | 22369663 | |
204 | Ubiquitination | TQSQFISKSVSNASL HHHHHHHHHHHCCCC | 50.49 | 17644757 | |
205 | Phosphorylation | QSQFISKSVSNASLD HHHHHHHHHHCCCCC | 24.80 | 22369663 | |
207 | Phosphorylation | QFISKSVSNASLDTQ HHHHHHHHCCCCCCC | 33.50 | 22369663 | |
210 | Phosphorylation | SKSVSNASLDTQNTF HHHHHCCCCCCCCCH | 30.91 | 22369663 | |
213 | Phosphorylation | VSNASLDTQNTFEQN HHCCCCCCCCCHHHH | 29.07 | 22369663 | |
216 | Phosphorylation | ASLDTQNTFEQNVES CCCCCCCCHHHHHHH | 20.80 | 25521595 | |
223 | Phosphorylation | TFEQNVESDKNFNKL CHHHHHHHCCCHHHC | 49.99 | 22369663 | |
225 | Ubiquitination | EQNVESDKNFNKLNR HHHHHHCCCHHHCCC | 73.12 | 17644757 | |
234 | Phosphorylation | FNKLNRNTTNSGSLY HHHCCCCCCCCCCCC | 24.90 | 19779198 | |
235 | Phosphorylation | NKLNRNTTNSGSLYH HHCCCCCCCCCCCCC | 30.82 | 19795423 | |
237 | Phosphorylation | LNRNTTNSGSLYHSS CCCCCCCCCCCCCCC | 27.89 | 19779198 | |
239 | Phosphorylation | RNTTNSGSLYHSSSN CCCCCCCCCCCCCCC | 26.10 | 19795423 | |
241 | Phosphorylation | TTNSGSLYHSSSNSG CCCCCCCCCCCCCCC | 11.01 | 19795423 | |
243 | Phosphorylation | NSGSLYHSSSNSGSS CCCCCCCCCCCCCCC | 23.16 | 21440633 | |
244 | Phosphorylation | SGSLYHSSSNSGSSA CCCCCCCCCCCCCCC | 21.89 | 21440633 | |
245 | Phosphorylation | GSLYHSSSNSGSSAS CCCCCCCCCCCCCCC | 37.72 | 21440633 | |
247 | Phosphorylation | LYHSSSNSGSSASLE CCCCCCCCCCCCCHH | 41.84 | 21440633 | |
249 | Phosphorylation | HSSSNSGSSASLESE CCCCCCCCCCCHHHC | 23.66 | 21440633 | |
250 | Phosphorylation | SSSNSGSSASLESEN CCCCCCCCCCHHHCC | 25.96 | 21440633 | |
252 | Phosphorylation | SNSGSSASLESENAH CCCCCCCCHHHCCCC | 34.32 | 21440633 | |
255 | Phosphorylation | GSSASLESENAHYPK CCCCCHHHCCCCCCC | 41.25 | 19795423 | |
260 | Phosphorylation | LESENAHYPKRNIWN HHHCCCCCCCCCCEE | 14.19 | 19779198 | |
271 | Phosphorylation | NIWNVANTPVFRPSN CCEECCCCCCCCCCC | 15.87 | 28889911 | |
460 | Ubiquitination | NNSNNANKQANPYLE CCCCCCCHHCCHHHH | 48.67 | 15699485 | |
465 | Phosphorylation | ANKQANPYLENSIPT CCHHCCHHHHCCCCC | 26.84 | 28889911 | |
473 | Ubiquitination | LENSIPTKNTSKKNA HHCCCCCCCCCCCCC | 53.53 | 15699485 | |
475 | Phosphorylation | NSIPTKNTSKKNASS CCCCCCCCCCCCCCC | 43.40 | 19779198 | |
515 | Phosphorylation | QQQTYHRSPLLEQLR HHHHHHHHHHHHHHH | 13.44 | 22369663 | |
528 | Ubiquitination | LRNSSSDKNSNSNMS HHCCCCCCCCCCCCC | 65.31 | 23749301 | |
530 | Phosphorylation | NSSSDKNSNSNMSLK CCCCCCCCCCCCCHH | 47.58 | 29650682 | |
553 | Phosphorylation | FCKDQHGSRFIQREL HHHHHHCCHHHHHHH | 23.15 | 19823750 | |
562 | Phosphorylation | FIQRELATSPASEKE HHHHHHCCCCCCHHH | 48.11 | 24961812 | |
563 | Phosphorylation | IQRELATSPASEKEV HHHHHCCCCCCHHHH | 16.92 | 25752575 | |
566 | Phosphorylation | ELATSPASEKEVIFN HHCCCCCCHHHHHHH | 53.22 | 19823750 | |
666 | Acetylation | NGNHVIQKAIETIPI CCCCHHHHHHHHCCH | 39.96 | 24489116 | |
780 | Acetylation | FASNVVEKSILYGSK CHHCHHHHHHHHCCC | 31.05 | 24489116 | |
866 | Phosphorylation | LGNRHLASVEKLAAL CCHHHHHHHHHHHHH | 36.85 | 27214570 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
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Oops, there are no upstream regulatory protein records of PUF3_YEAST !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
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Oops, there are no descriptions of PTM sites of PUF3_YEAST !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PUF3_YEAST !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-207; SER-210;THR-213 AND SER-563, AND MASS SPECTROMETRY. | |
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-205; SER-207 ANDSER-210, AND MASS SPECTROMETRY. | |
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-83 AND SER-207, AND MASSSPECTROMETRY. |