MAM3_YEAST - dbPTM
MAM3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAM3_YEAST
UniProt AC Q12296
Protein Name Protein MAM3
Gene Name MAM3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 706
Subcellular Localization Vacuole membrane
Multi-pass membrane protein .
Protein Description Involved in metal homeostasis and more specially in manganese sensitivity..
Protein Sequence MSFLPLRSRSRSGAPHWVYIILYHIFTIPKIYSLPLLSGSHVLNSRDVADSGHSVGDEASVTTYYIISIILVLLGGVFAGLTLGLMGQDEVYLKVISTSGSNSEKKLAKRVLDLISRGKHWVLVTLLLSNVITNETLPIVLDRCLGGGWQAVVSSTILIVIFGEIIPQSVCVKYGLQVGAFFCPFVLVLMYLMYPVAYPIATLLDYMLGEDHGTMYKKSGLKTLVTLHRTMGVERLTKDEVTIISAVLDLKAKRVEEIMTPIENVFTMSADTILDDKTVEKIFNSGFSRIPIFLPNEPNNFIGMLLVRVLISYDPDDCLPISHFPLATLPETSPNTSCLNILNYFQEGKAHMCVVSKEPGSSHGAIGVLTLEDVIEELIGEEIVDESDVFVDMHQHIMRQQPGPLSKRHITSYLHHLYTSSHKEHKAADQADESSPLLSPSNSNHPSEHPQQDLNNKSWKQKSNDGYDRSNAVLSPTPQVTEHGTIIPSNLASNPLNVNKSFVTIKKPANVPKIITTHTPHSSKEPSPAPHSNDKSLSAEEQQLLSDHAELSRQAVLHTQRSGQPTQVTTSTKTTRNSPDSISIPNSGANHGNENQNVTISTSYQNTKNGIVESVITVKGVPKTIIGPAKDWDESKSEYGNENINQENSNRSDDRESSSSNASLFSSIKNKFKNENANNNDRSNFTDSLSRTSNYDANGSSSTIKR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
45PhosphorylationSGSHVLNSRDVADSG
CCCEECCCCCCCCCC		26.2028889911
223PhosphorylationYKKSGLKTLVTLHRT
CCHHCHHHHHHHHHH		31.3530377154
226PhosphorylationSGLKTLVTLHRTMGV
HCHHHHHHHHHHHCC		21.6930377154
230PhosphorylationTLVTLHRTMGVERLT
HHHHHHHHHCCCCCC		13.9230377154
237PhosphorylationTMGVERLTKDEVTII
HHCCCCCCHHHHHHH		42.5419779198
238UbiquitinationMGVERLTKDEVTIIS
HCCCCCCHHHHHHHH		57.3817644757
242PhosphorylationRLTKDEVTIISAVLD
CCCHHHHHHHHHHHH		15.5619795423
245PhosphorylationKDEVTIISAVLDLKA
HHHHHHHHHHHHHHC		14.4219795423
251UbiquitinationISAVLDLKAKRVEEI
HHHHHHHHCHHHHHH		52.0817644757
407UbiquitinationQQPGPLSKRHITSYL
CCCCCCCHHHHHHHH		56.5323749301
434PhosphorylationAADQADESSPLLSPS
HHHCCCCCCCCCCCC		37.4922369663
435PhosphorylationADQADESSPLLSPSN
HHCCCCCCCCCCCCC		19.9522369663
439PhosphorylationDESSPLLSPSNSNHP
CCCCCCCCCCCCCCC		33.6822369663
441PhosphorylationSSPLLSPSNSNHPSE
CCCCCCCCCCCCCCC		49.9022369663
443PhosphorylationPLLSPSNSNHPSEHP
CCCCCCCCCCCCCCC		40.6322369663
447PhosphorylationPSNSNHPSEHPQQDL
CCCCCCCCCCCCCCC		40.7722369663
458PhosphorylationQQDLNNKSWKQKSND
CCCCCCCCHHHHCCC		41.4521440633
463PhosphorylationNKSWKQKSNDGYDRS
CCCHHHHCCCCCCCC		37.3528889911
470PhosphorylationSNDGYDRSNAVLSPT
CCCCCCCCCCEECCC		26.6622369663
475PhosphorylationDRSNAVLSPTPQVTE
CCCCCEECCCCCCCC		21.8222369663
477PhosphorylationSNAVLSPTPQVTEHG
CCCEECCCCCCCCCC		23.9920377248
481PhosphorylationLSPTPQVTEHGTIIP
ECCCCCCCCCCEECC		19.6022369663
485PhosphorylationPQVTEHGTIIPSNLA
CCCCCCCEECCCCCC		20.0320377248
500UbiquitinationSNPLNVNKSFVTIKK
CCCCCCCCCCEEEEC		40.7717644757
501PhosphorylationNPLNVNKSFVTIKKP
CCCCCCCCCEEEECC		21.5322369663
516PhosphorylationANVPKIITTHTPHSS
CCCCEEEECCCCCCC		18.9220377248
517PhosphorylationNVPKIITTHTPHSSK
CCCEEEECCCCCCCC		17.2220377248
519PhosphorylationPKIITTHTPHSSKEP
CEEEECCCCCCCCCC		22.1722369663
522PhosphorylationITTHTPHSSKEPSPA
EECCCCCCCCCCCCC		44.2922369663
523PhosphorylationTTHTPHSSKEPSPAP
ECCCCCCCCCCCCCC		37.6922369663
527PhosphorylationPHSSKEPSPAPHSND
CCCCCCCCCCCCCCC		34.4822369663
532PhosphorylationEPSPAPHSNDKSLSA
CCCCCCCCCCCCCCH		45.7420377248
535UbiquitinationPAPHSNDKSLSAEEQ
CCCCCCCCCCCHHHH		58.5117644757
536PhosphorylationAPHSNDKSLSAEEQQ
CCCCCCCCCCHHHHH		30.3524961812
538PhosphorylationHSNDKSLSAEEQQLL
CCCCCCCCHHHHHHH		40.5028889911
562PhosphorylationAVLHTQRSGQPTQVT
HHHHHHCCCCCCEEE		31.7823749301
573UbiquitinationTQVTTSTKTTRNSPD
CEEEECCEECCCCCC		47.9023749301
574PhosphorylationQVTTSTKTTRNSPDS
EEEECCEECCCCCCC		30.9520377248
575PhosphorylationVTTSTKTTRNSPDSI
EEECCEECCCCCCCE		29.4320377248
578PhosphorylationSTKTTRNSPDSISIP
CCEECCCCCCCEECC		27.1320377248
581PhosphorylationTTRNSPDSISIPNSG
ECCCCCCCEECCCCC		22.9420377248
583PhosphorylationRNSPDSISIPNSGAN
CCCCCCEECCCCCCC		35.6320377248
587PhosphorylationDSISIPNSGANHGNE
CCEECCCCCCCCCCC		33.6520377248
599PhosphorylationGNENQNVTISTSYQN
CCCCCCEEEEECEEE		19.4322369663
601PhosphorylationENQNVTISTSYQNTK
CCCCEEEEECEEECC		11.2622369663
602PhosphorylationNQNVTISTSYQNTKN
CCCEEEEECEEECCC		27.8322369663
603PhosphorylationQNVTISTSYQNTKNG
CCEEEEECEEECCCC		20.2422369663
604PhosphorylationNVTISTSYQNTKNGI
CEEEEECEEECCCCE		13.0822369663
607PhosphorylationISTSYQNTKNGIVES
EEECEEECCCCEEEE		15.4522369663
614PhosphorylationTKNGIVESVITVKGV
CCCCEEEEEEEECCC		14.1321551504
617PhosphorylationGIVESVITVKGVPKT
CEEEEEEEECCCCCE		17.6319684113
624PhosphorylationTVKGVPKTIIGPAKD
EECCCCCEEECCCCC		16.2621440633
635PhosphorylationPAKDWDESKSEYGNE
CCCCCCHHHHHHCCC		38.7222369663
636UbiquitinationAKDWDESKSEYGNEN
CCCCCHHHHHHCCCC		45.3023749301
637PhosphorylationKDWDESKSEYGNENI
CCCCHHHHHHCCCCC		45.3822369663
639PhosphorylationWDESKSEYGNENINQ
CCHHHHHHCCCCCCC		32.1322369663
649PhosphorylationENINQENSNRSDDRE
CCCCCCCCCCCCCCC		32.6322369663
652PhosphorylationNQENSNRSDDRESSS
CCCCCCCCCCCCHHH		48.3822890988
657PhosphorylationNRSDDRESSSSNASL
CCCCCCCHHHHHHHH		36.0922369663
658PhosphorylationRSDDRESSSSNASLF
CCCCCCHHHHHHHHH		32.7922890988
659PhosphorylationSDDRESSSSNASLFS
CCCCCHHHHHHHHHH		36.5722890988
660PhosphorylationDDRESSSSNASLFSS
CCCCHHHHHHHHHHH		38.0622369663
663PhosphorylationESSSSNASLFSSIKN
CHHHHHHHHHHHHHH		33.9122890988
666PhosphorylationSSNASLFSSIKNKFK
HHHHHHHHHHHHHHC		36.1322890988
667PhosphorylationSNASLFSSIKNKFKN
HHHHHHHHHHHHHCC		30.1922890988
673UbiquitinationSSIKNKFKNENANNN
HHHHHHHCCCCCCCC		66.0323749301
686PhosphorylationNNDRSNFTDSLSRTS
CCCCCCCCHHHHCCC		29.0022369663
688PhosphorylationDRSNFTDSLSRTSNY
CCCCCCHHHHCCCCC		25.7822369663
690PhosphorylationSNFTDSLSRTSNYDA
CCCCHHHHCCCCCCC		37.1522369663
692PhosphorylationFTDSLSRTSNYDANG
CCHHHHCCCCCCCCC		20.2522369663
693PhosphorylationTDSLSRTSNYDANGS
CHHHHCCCCCCCCCC		32.0822369663
695PhosphorylationSLSRTSNYDANGSSS
HHHCCCCCCCCCCCC		19.0523749301
700PhosphorylationSNYDANGSSSTIKR-
CCCCCCCCCCCCCC-		22.4122369663
701PhosphorylationNYDANGSSSTIKR--
CCCCCCCCCCCCC--		32.6622369663
702PhosphorylationYDANGSSSTIKR---
CCCCCCCCCCCC---		35.5323749301
703PhosphorylationDANGSSSTIKR----
CCCCCCCCCCC----		32.2523749301
705UbiquitinationNGSSSTIKR------
CCCCCCCCC------		52.7423749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MAM3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAM3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAM3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RT05_YEASTMRPS5physical
22940862
RT09_YEASTMRPS9physical
22940862
RT35_YEASTMRPS35physical
22940862
RT25_YEASTRSM25physical
22940862
RT01_YEASTMRP1physical
22940862
RT13_YEASTMRP13physical
22940862
HOS2_YEASTHOS2genetic
27708008
FUI1_YEASTFUI1genetic
27708008
AST1_YEASTAST1genetic
27708008
RCR1_YEASTRCR1genetic
27708008
ECM33_YEASTECM33genetic
27708008
ERV15_YEASTERV15genetic
27708008
RIM1_YEASTRIM1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
PAA1_YEASTPAA1genetic
27708008
INO2_YEASTINO2genetic
27708008
BCS1_YEASTBCS1genetic
27708008
PDR15_YEASTPDR15genetic
27708008
RTF1_YEASTRTF1genetic
27708008
CHO2_YEASTCHO2genetic
27708008
YG51_YEASTYGR237Cgenetic
27708008
SODM_YEASTSOD2genetic
27708008
MED20_YEASTSRB2genetic
27708008
ARP1_YEASTARP1genetic
27708008
MPH1_YEASTMPH1genetic
27708008
DAL81_YEASTDAL81genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
ELM1_YEASTELM1genetic
27708008
APE2_YEASTAPE2genetic
27708008
GAS1_YEASTGAS1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAM3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45; SER-439; SER-441;SER-538; SER-614; SER-660 AND THR-692, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-519; SER-523 ANDSER-527, AND MASS SPECTROMETRY.

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