| UniProt ID | PAA1_YEAST | |
|---|---|---|
| UniProt AC | Q12447 | |
| Protein Name | Polyamine N-acetyltransferase 1 | |
| Gene Name | PAA1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 191 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Acetylates spermine and probably also other polyamines such as putrescine or spermidine. May regulate the levels of polyamines on chromosomal DNA, which would modify chromatin structure and affect transcription or replication. Also able to acetylate arylalkylamines such as tryptamine and serotonin in vitro.. | |
| Protein Sequence | MASSSSTLPLHMYIRPLIIEDLKQILNLESQGFPPNERASEEIISFRLINCPELCSGLFIREIEGKEVKKETLIGHIMGTKIPHEYITIESMGKLQVESSNHIGIHSVVIKPEYQKKNLATLLLTDYIQKLSNQEIGNKIVLIAHEPLIPFYERVGFKIIAENTNVAKDKNFAEQKWIDMERELIKEEYDN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MASSSSTLPL -----CCCCCCCCCC | 29.47 | 30377154 | |
| 4 | Phosphorylation | ----MASSSSTLPLH ----CCCCCCCCCCH | 20.83 | 30377154 | |
| 5 | Phosphorylation | ---MASSSSTLPLHM ---CCCCCCCCCCHH | 25.50 | 30377154 | |
| 6 | Phosphorylation | --MASSSSTLPLHMY --CCCCCCCCCCHHH | 35.59 | 30377154 | |
| 13 | Phosphorylation | STLPLHMYIRPLIIE CCCCCHHHCHHHHHH | 5.30 | 28132839 | |
| 117 | Acetylation | IKPEYQKKNLATLLL ECHHHHHCCHHHHHH | 41.49 | 24489116 | |
| 168 | Ubiquitination | AENTNVAKDKNFAEQ EECCCCCCCCCHHHH | 66.02 | 23749301 | |
| 168 | Acetylation | AENTNVAKDKNFAEQ EECCCCCCCCCHHHH | 66.02 | 24489116 | |
| 170 | Ubiquitination | NTNVAKDKNFAEQKW CCCCCCCCCHHHHHH | 53.94 | 23749301 | |
| 170 | Acetylation | NTNVAKDKNFAEQKW CCCCCCCCCHHHHHH | 53.94 | 24489116 | |
| 176 | Acetylation | DKNFAEQKWIDMERE CCCHHHHHHHHHHHH | 37.31 | 24489116 | |
| 186 | Ubiquitination | DMERELIKEEYDN-- HHHHHHHHHHHCC-- | 58.06 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PAA1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PAA1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PAA1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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