| UniProt ID | APA2_YEAST | |
|---|---|---|
| UniProt AC | P22108 | |
| Protein Name | Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2 {ECO:0000303|PubMed:2174863} | |
| Gene Name | APA2 {ECO:0000303|PubMed:2174863} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 325 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Ap4A phosphorylase catalyzes the phosphorolytic degradation of bis(5'-adenosyl) tetraphosphate (Ap4A) into ADP and ATP. Can also use other Np4N' nucleotides (where N and N' stand for A,C,G or U) as substrates, but prefers A-containing substrates. Cannot catalyze the reverse reaction. Additionally, this enzyme can also catalyze the phosphorolytic degradation of adenosine 5'-phosphosulfate (AMPS) into ADP and sulfate, the reversible exchange reaction between inorganic phosphate and the beta-phosphate of a nucleoside diphosphate (NDP), and the synthesis of Ap4A from AMPS plus ATP.. | |
| Protein Sequence | MIEENLKQKIHDKFVAAKKNGHLKVTHAESKKLKDPQTTTQYWVTFAPSLALKPDANKNSDSKAEDPFANPDEELVVTEDLNGDGEYKLLLNKFPVVPEHSLLVTSEFKDQRSALTPSDLMTAYNVLCSLQGDKDDDVTCERYLVFYNCGPHSGSSQDHKHLQIMQMPEKFIPFQDVLCNGKDHFLPTFNAEPLQDDKVSFAHFVLPLPESSDQVDEDLLAMCYVSLMQRALTFFQDWTNESPELTKSYNVLLTKKWICVVPRSHAKSGPPLMLNINSTGYCGMILVKDREKLENLTEDPHLVDKSLLQCGFPNTAGQKPTEYHY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of APA2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of APA2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of APA2_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| APA1_YEAST | APA1 | genetic | 18408719 | |
| DCOR_YEAST | SPE1 | genetic | 21623372 | |
| POS5_YEAST | POS5 | genetic | 21623372 | |
| QCR8_YEAST | QCR8 | genetic | 21623372 | |
| THRC_YEAST | THR4 | genetic | 21623372 | |
| ATP14_YEAST | ATP14 | genetic | 21623372 | |
| ELO2_YEAST | ELO2 | genetic | 21623372 | |
| KCS1_YEAST | KCS1 | genetic | 21623372 | |
| GAS4_YEAST | GAS4 | genetic | 21623372 | |
| SEC22_YEAST | SEC22 | genetic | 27708008 | |
| CLP1_YEAST | CLP1 | genetic | 27708008 | |
| SNU23_YEAST | SNU23 | genetic | 27708008 | |
| PDC2_YEAST | PDC2 | genetic | 27708008 | |
| SEC7_YEAST | SEC7 | genetic | 27708008 | |
| GPI8_YEAST | GPI8 | genetic | 27708008 | |
| GPI10_YEAST | GPI10 | genetic | 27708008 | |
| BIG1_YEAST | BIG1 | genetic | 27708008 | |
| GWT1_YEAST | GWT1 | genetic | 27708008 | |
| NTR2_YEAST | NTR2 | genetic | 27708008 | |
| SDO1_YEAST | SDO1 | genetic | 27708008 | |
| DBP6_YEAST | DBP6 | genetic | 27708008 | |
| NUF2_YEAST | NUF2 | genetic | 27708008 | |
| TYSY_YEAST | CDC21 | genetic | 27708008 | |
| TBF1_YEAST | TBF1 | genetic | 27708008 | |
| DIM1_YEAST | DIM1 | genetic | 27708008 | |
| DIB1_YEAST | DIB1 | genetic | 27708008 | |
| BUR1_YEAST | SGV1 | genetic | 27708008 | |
| SNF6_YEAST | SNF6 | genetic | 27708008 | |
| VRP1_YEAST | VRP1 | genetic | 27708008 | |
| RAS2_YEAST | RAS2 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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