| UniProt ID | VRP1_YEAST | |
|---|---|---|
| UniProt AC | P37370 | |
| Protein Name | Verprolin | |
| Gene Name | VRP1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 817 | |
| Subcellular Localization | Cytoplasm, cytoskeleton . | |
| Protein Description | Involved in cytoskeletal organization and cellular growth. May exert its effects on the cytoskeleton directly, or indirectly via proline-binding proteins (e.g. profilin) or proteins possessing SH3 domains.. | |
| Protein Sequence | MAGAPAPPPPPPPPALGGSAPKPAKSVMQGRDALLGDIRKGMKLKKAETNDRSAPIVGGGVVSSASGSSGTVSSKGPSMSAPPIPGMGAPQLGDILAGGIPKLKHINNNASTKPSPSASAPPIPGAVPSVAAPPIPNAPLSPAPAVPSIPSSSAPPIPDIPSSAAPPIPIVPSSPAPPLPLSGASAPKVPQNRPHMPSVRPAHRSHQRKSSNISLPSVSAPPLPSASLPTHVSNPPQAPPPPPTPTIGLDSKNIKPTDNAVSPPSSEVPAGGLPFLAEINARRSERGAVEGVSSTKIQTENHKSPSQPPLPSSAPPIPTSHAPPLPPTAPPPPSLPNVTSAPKKATSAPAPPPPPLPAAMSSASTNSVKATPVPPTLAPPLPNTTSVPPNKASSMPAPPPPPPPPPGAFSTSSALSASSIPLAPLPPPPPPSVATSVPSAPPPPPTLTTNKPSASSKQSKISSSSSSSAVTPGGPLPFLAEIQKKRDDRFVVGGDTGYTTQDKQEDVIGSSKDDNVRPSPISPSINPPKQSSQNGMSFLDEIESKLHKQTSSNAFNAPPPHTDAMAPPLPPSAPPPPITSLPTPTASGDDHTNDKSETVLGMKKAKAPALPGHVPPPPVPPVLSDDSKNNVPAASLLHDVLPSSNLEKPPSPPVAAAPPLPTFSAPSLPQQSVSTSIPSPPPVAPTLSVRTETESISKNPTKSPPPPPSPSTMDTGTSNSPSKNLKQRLFSTGGSTLQHKHNTHTNQPDVDVGRYTIGGSNSIVGAKSGNERIVIDDSRFKWTNVSQMPKPRPFQNKTKLYPSGKGSSVPLDLTLFT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 49 | Phosphorylation | MKLKKAETNDRSAPI CCCEECCCCCCCCCE | 47.48 | 20377248 | |
| 53 | Phosphorylation | KAETNDRSAPIVGGG ECCCCCCCCCEECCC | 41.06 | 20377248 | |
| 63 | Phosphorylation | IVGGGVVSSASGSSG EECCCEEECCCCCCC | 20.13 | 22369663 | |
| 64 | Phosphorylation | VGGGVVSSASGSSGT ECCCEEECCCCCCCC | 18.16 | 22369663 | |
| 66 | Phosphorylation | GGVVSSASGSSGTVS CCEEECCCCCCCCCC | 40.95 | 22369663 | |
| 68 | Phosphorylation | VVSSASGSSGTVSSK EEECCCCCCCCCCCC | 24.09 | 22369663 | |
| 69 | Phosphorylation | VSSASGSSGTVSSKG EECCCCCCCCCCCCC | 41.85 | 22369663 | |
| 71 | Phosphorylation | SASGSSGTVSSKGPS CCCCCCCCCCCCCCC | 21.11 | 22369663 | |
| 73 | Phosphorylation | SGSSGTVSSKGPSMS CCCCCCCCCCCCCCC | 26.60 | 22369663 | |
| 74 | Phosphorylation | GSSGTVSSKGPSMSA CCCCCCCCCCCCCCC | 36.98 | 22369663 | |
| 109 | N-linked_Glycosylation | KLKHINNNASTKPSP CCEECCCCCCCCCCC | 30.68 | - | |
| 210 | Phosphorylation | HRSHQRKSSNISLPS CHHHCCCCCCCCCCC | 30.70 | 20377248 | |
| 211 | Phosphorylation | RSHQRKSSNISLPSV HHHCCCCCCCCCCCC | 41.01 | 20377248 | |
| 212 | N-linked_Glycosylation | SHQRKSSNISLPSVS HHCCCCCCCCCCCCC | 34.65 | - | |
| 214 | Phosphorylation | QRKSSNISLPSVSAP CCCCCCCCCCCCCCC | 38.18 | 20377248 | |
| 217 | Phosphorylation | SSNISLPSVSAPPLP CCCCCCCCCCCCCCC | 33.72 | 20377248 | |
| 219 | Phosphorylation | NISLPSVSAPPLPSA CCCCCCCCCCCCCCC | 39.12 | 20377248 | |
| 225 | Phosphorylation | VSAPPLPSASLPTHV CCCCCCCCCCCCCCC | 37.87 | 21440633 | |
| 227 | Phosphorylation | APPLPSASLPTHVSN CCCCCCCCCCCCCCC | 38.94 | 30377154 | |
| 230 | Phosphorylation | LPSASLPTHVSNPPQ CCCCCCCCCCCCCCC | 39.96 | 20377248 | |
| 233 | Phosphorylation | ASLPTHVSNPPQAPP CCCCCCCCCCCCCCC | 35.69 | 28132839 | |
| 244 | Phosphorylation | QAPPPPPTPTIGLDS CCCCCCCCCCCCCCC | 38.55 | 21440633 | |
| 246 | Phosphorylation | PPPPPTPTIGLDSKN CCCCCCCCCCCCCCC | 30.10 | 21440633 | |
| 257 | Phosphorylation | DSKNIKPTDNAVSPP CCCCCCCCCCCCCCC | 36.56 | 22369663 | |
| 262 | Phosphorylation | KPTDNAVSPPSSEVP CCCCCCCCCCCCCCC | 28.78 | 22369663 | |
| 265 | Phosphorylation | DNAVSPPSSEVPAGG CCCCCCCCCCCCCCC | 42.38 | 22369663 | |
| 266 | Phosphorylation | NAVSPPSSEVPAGGL CCCCCCCCCCCCCCC | 48.68 | 22369663 | |
| 284 | Phosphorylation | AEINARRSERGAVEG EEHHHHHHCCCCCCC | 26.54 | 22369663 | |
| 293 | Phosphorylation | RGAVEGVSSTKIQTE CCCCCCCCCCCEECC | 43.05 | 22369663 | |
| 294 | Phosphorylation | GAVEGVSSTKIQTEN CCCCCCCCCCEECCC | 31.17 | 22369663 | |
| 295 | Phosphorylation | AVEGVSSTKIQTENH CCCCCCCCCEECCCC | 25.35 | 22369663 | |
| 299 | Phosphorylation | VSSTKIQTENHKSPS CCCCCEECCCCCCCC | 42.08 | 21440633 | |
| 304 | Phosphorylation | IQTENHKSPSQPPLP EECCCCCCCCCCCCC | 23.41 | 20377248 | |
| 306 | Phosphorylation | TENHKSPSQPPLPSS CCCCCCCCCCCCCCC | 63.51 | 20377248 | |
| 319 | Phosphorylation | SSAPPIPTSHAPPLP CCCCCCCCCCCCCCC | 33.59 | 20377248 | |
| 328 | Phosphorylation | HAPPLPPTAPPPPSL CCCCCCCCCCCCCCC | 50.27 | 21440633 | |
| 337 | N-linked_Glycosylation | PPPPSLPNVTSAPKK CCCCCCCCCCCCCCC | 55.80 | - | |
| 346 | Phosphorylation | TSAPKKATSAPAPPP CCCCCCCCCCCCCCC | 34.01 | 22369663 | |
| 347 | Phosphorylation | SAPKKATSAPAPPPP CCCCCCCCCCCCCCC | 36.80 | 22369663 | |
| 361 | Phosphorylation | PPLPAAMSSASTNSV CCCCCCCCCCCCCCC | 20.30 | 22369663 | |
| 362 | Phosphorylation | PLPAAMSSASTNSVK CCCCCCCCCCCCCCC | 17.10 | 20377248 | |
| 364 | Phosphorylation | PAAMSSASTNSVKAT CCCCCCCCCCCCCCC | 30.03 | 22369663 | |
| 365 | Phosphorylation | AAMSSASTNSVKATP CCCCCCCCCCCCCCC | 31.09 | 22369663 | |
| 367 | Phosphorylation | MSSASTNSVKATPVP CCCCCCCCCCCCCCC | 25.69 | 20377248 | |
| 383 | N-linked_Glycosylation | TLAPPLPNTTSVPPN CCCCCCCCCCCCCCC | 64.77 | - | |
| 462 | Phosphorylation | SSKQSKISSSSSSSA CCCCCCCCCCCCCCC | 28.09 | 21440633 | |
| 463 | Phosphorylation | SKQSKISSSSSSSAV CCCCCCCCCCCCCCC | 37.40 | 23749301 | |
| 464 | Phosphorylation | KQSKISSSSSSSAVT CCCCCCCCCCCCCCC | 27.70 | 21440633 | |
| 465 | Phosphorylation | QSKISSSSSSSAVTP CCCCCCCCCCCCCCC | 35.87 | 21440633 | |
| 466 | Phosphorylation | SKISSSSSSSAVTPG CCCCCCCCCCCCCCC | 30.20 | 17563356 | |
| 467 | Phosphorylation | KISSSSSSSAVTPGG CCCCCCCCCCCCCCC | 25.02 | 17563356 | |
| 468 | Phosphorylation | ISSSSSSSAVTPGGP CCCCCCCCCCCCCCC | 28.80 | 21551504 | |
| 471 | Phosphorylation | SSSSSAVTPGGPLPF CCCCCCCCCCCCCCH | 18.88 | 28152593 | |
| 484 | Acetylation | PFLAEIQKKRDDRFV CHHHHHHHHCCCCEE | 56.27 | 24489116 | |
| 496 | Phosphorylation | RFVVGGDTGYTTQDK CEEECCCCCCCCCCC | 35.05 | 27017623 | |
| 498 | Phosphorylation | VVGGDTGYTTQDKQE EECCCCCCCCCCCCH | 14.54 | 27017623 | |
| 500 | Phosphorylation | GGDTGYTTQDKQEDV CCCCCCCCCCCCHHC | 26.70 | 27017623 | |
| 503 | Acetylation | TGYTTQDKQEDVIGS CCCCCCCCCHHCCCC | 45.85 | 24489116 | |
| 519 | Phosphorylation | KDDNVRPSPISPSIN CCCCCCCCCCCCCCC | 25.05 | 22369663 | |
| 522 | Phosphorylation | NVRPSPISPSINPPK CCCCCCCCCCCCCCC | 18.91 | 25521595 | |
| 524 | Phosphorylation | RPSPISPSINPPKQS CCCCCCCCCCCCCCC | 28.36 | 25521595 | |
| 531 | Phosphorylation | SINPPKQSSQNGMSF CCCCCCCCCCCCCHH | 39.76 | 22369663 | |
| 532 | Phosphorylation | INPPKQSSQNGMSFL CCCCCCCCCCCCHHH | 25.77 | 22369663 | |
| 545 | Acetylation | FLDEIESKLHKQTSS HHHHHHHHHHHHCCC | 41.65 | 24489116 | |
| 624 | Phosphorylation | PPVPPVLSDDSKNNV CCCCCCCCCCCCCCC | 39.34 | 21551504 | |
| 691 | Phosphorylation | APTLSVRTETESISK CCCEEEEECCCCCCC | 45.14 | 21082442 | |
| 693 | Phosphorylation | TLSVRTETESISKNP CEEEEECCCCCCCCC | 34.13 | 28132839 | |
| 695 | Phosphorylation | SVRTETESISKNPTK EEEECCCCCCCCCCC | 39.31 | 22369663 | |
| 697 | Phosphorylation | RTETESISKNPTKSP EECCCCCCCCCCCCC | 35.34 | 22369663 | |
| 701 | Phosphorylation | ESISKNPTKSPPPPP CCCCCCCCCCCCCCC | 54.25 | 22369663 | |
| 703 | Phosphorylation | ISKNPTKSPPPPPSP CCCCCCCCCCCCCCC | 45.15 | 22369663 | |
| 709 | Phosphorylation | KSPPPPPSPSTMDTG CCCCCCCCCCCCCCC | 36.94 | 22369663 | |
| 711 | Phosphorylation | PPPPPSPSTMDTGTS CCCCCCCCCCCCCCC | 40.47 | 25521595 | |
| 712 | Phosphorylation | PPPPSPSTMDTGTSN CCCCCCCCCCCCCCC | 23.58 | 22369663 | |
| 715 | Phosphorylation | PSPSTMDTGTSNSPS CCCCCCCCCCCCCCC | 31.38 | 20377248 | |
| 717 | Phosphorylation | PSTMDTGTSNSPSKN CCCCCCCCCCCCCCC | 27.16 | 22369663 | |
| 718 | Phosphorylation | STMDTGTSNSPSKNL CCCCCCCCCCCCCCH | 36.33 | 22369663 | |
| 720 | Phosphorylation | MDTGTSNSPSKNLKQ CCCCCCCCCCCCHHH | 30.25 | 22369663 | |
| 722 | Phosphorylation | TGTSNSPSKNLKQRL CCCCCCCCCCHHHHH | 33.72 | 22369663 | |
| 731 | Phosphorylation | NLKQRLFSTGGSTLQ CHHHHHHHCCCCHHH | 30.63 | 22369663 | |
| 732 | Phosphorylation | LKQRLFSTGGSTLQH HHHHHHHCCCCHHHH | 37.92 | 22369663 | |
| 735 | Phosphorylation | RLFSTGGSTLQHKHN HHHHCCCCHHHHCCC | 27.56 | 22369663 | |
| 736 | Phosphorylation | LFSTGGSTLQHKHNT HHHCCCCHHHHCCCC | 33.44 | 22369663 | |
| 756 | Phosphorylation | DVDVGRYTIGGSNSI CCCCCEEECCCCCCE | 16.28 | 28889911 | |
| 760 | Phosphorylation | GRYTIGGSNSIVGAK CEEECCCCCCEECCC | 23.38 | 22369663 | |
| 762 | Phosphorylation | YTIGGSNSIVGAKSG EECCCCCCEECCCCC | 21.98 | 22369663 | |
| 767 | Ubiquitination | SNSIVGAKSGNERIV CCCEECCCCCCEEEE | 53.63 | 23749301 | |
| 768 | Phosphorylation | NSIVGAKSGNERIVI CCEECCCCCCEEEEE | 46.44 | 24961812 | |
| 784 | N-linked_Glycosylation | DSRFKWTNVSQMPKP CCCCCEECHHHCCCC | 30.26 | - | |
| 786 | Phosphorylation | RFKWTNVSQMPKPRP CCCEECHHHCCCCCC | 23.88 | 30377154 | |
| 796 | N-linked_Glycosylation | PKPRPFQNKTKLYPS CCCCCCCCCCCCCCC | 55.11 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VRP1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VRP1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VRP1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-519; SER-522; SER-524;SER-695; SER-703; THR-712; SER-720; THR-736; SER-760 AND SER-762, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-257; SER-466; SER-467AND THR-736, AND MASS SPECTROMETRY. | |
