MDHM_YEAST - dbPTM
MDHM_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MDHM_YEAST
UniProt AC P17505
Protein Name Malate dehydrogenase, mitochondrial
Gene Name MDH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 334
Subcellular Localization Mitochondrion matrix .
Protein Description
Protein Sequence MLSRVAKRAFSSTVANPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVATDLSHIPTNSVVKGFTPEEPDGLNNALKDTDMVLIPAGVPRKPGMTRDDLFAINASIVRDLAAATAESAPNAAILVISNPVNSTVPIVAQVLKNKGVYNPKKLFGVTTLDSIRAARFISEVENTDPTQERVNVIGGHSGITIIPLISQTNHKLMSDDKRHELIHRIQFGGDEVVKAKNGAGSATLSMAHAGAKFANAVLSGFKGERDVIEPSFVDSPLFKSEGIEFFASPVTLGPDGIEKIHPIGELSSEEEEMLQKCKETLKKNIEKGVNFVASK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Acetylation-MLSRVAKRAFSSTV
-CHHHHHHHHHHCCC		41.2125381059
422-HydroxyisobutyrylationLLLKLNHKVTDLRLY
HHHHHCCCCCCEEEE		45.84-
522-HydroxyisobutyrylationDLRLYDLKGAKGVAT
CEEEEECCCCCCEEC		54.66-
52AcetylationDLRLYDLKGAKGVAT
CEEEEECCCCCCEEC		54.6625381059
52SuccinylationDLRLYDLKGAKGVAT
CEEEEECCCCCCEEC		54.6623954790
59PhosphorylationKGAKGVATDLSHIPT
CCCCCEECCHHCCCC		34.7623749301
71AcetylationIPTNSVVKGFTPEEP
CCCCCCCCCCCCCCC		46.2624489116
159SuccinylationNKGVYNPKKLFGVTT
CCCCCCHHHHCCCCH		59.4723954790
166PhosphorylationKKLFGVTTLDSIRAA
HHHCCCCHHHHHHHH		26.6027017623
169PhosphorylationFGVTTLDSIRAARFI
CCCCHHHHHHHHHHH		19.6527017623
177PhosphorylationIRAARFISEVENTDP
HHHHHHHHHHCCCCC		32.6428889911
196PhosphorylationVNVIGGHSGITIIPL
EEEECCCCCEEEEEC		34.8525752575
199PhosphorylationIGGHSGITIIPLISQ
ECCCCCEEEEECEEC		19.1728889911
210AcetylationLISQTNHKLMSDDKR
CEECCCCCCCCCHHH		48.2124489116
213PhosphorylationQTNHKLMSDDKRHEL
CCCCCCCCCHHHHHH		53.7622369663
233AcetylationFGGDEVVKAKNGAGS
ECCHHEEECCCCCCC		59.8424489116
240PhosphorylationKAKNGAGSATLSMAH
ECCCCCCCCCHHHHH		19.9723749301
251AcetylationSMAHAGAKFANAVLS
HHHHHHHHHHHHHHH		44.0524489116
261AcetylationNAVLSGFKGERDVIE
HHHHHCCCCCCCCCC		64.4924489116
2612-HydroxyisobutyrylationNAVLSGFKGERDVIE
HHHHHCCCCCCCCCC		64.49-
278UbiquitinationFVDSPLFKSEGIEFF
HCCCCCCCCCCCEEE		56.1122106047
306PhosphorylationIHPIGELSSEEEEML
CCCCCCCCHHHHHHH		31.2522369663
307PhosphorylationHPIGELSSEEEEMLQ
CCCCCCCHHHHHHHH		62.7521440633
315AcetylationEEEEMLQKCKETLKK
HHHHHHHHHHHHHHH		43.2224489116
326AcetylationTLKKNIEKGVNFVAS
HHHHHHHHHHHHHCC		65.4524489116
333PhosphorylationKGVNFVASK------
HHHHHHCCC------		33.3322369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MDHM_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MDHM_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MDHM_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MDHC_YEASTMDH2genetic
1986231
MDHC_YEASTMDH2genetic
1447211
AATM_YEASTAAT1genetic
18381895
CY1_YEASTCYT1genetic
18381895
FOB1_YEASTFOB1genetic
18381895
SIR2_YEASTSIR2genetic
18381895
HST1_YEASTHST1genetic
18381895
HST2_YEASTHST2genetic
18381895
GPDM_YEASTGUT2genetic
18381895
NDI1_YEASTNDI1genetic
16941010
OAC1_YEASTOAC1genetic
16941010
DEP1_YEASTDEP1genetic
20093466
ODPA_YEASTPDA1genetic
20093466
RTG2_YEASTRTG2genetic
20093466
MED5_YEASTNUT1genetic
20093466
SSO2_YEASTSSO2genetic
20093466
AATC_YEASTAAT2genetic
21623372
ODP2_YEASTLAT1genetic
21623372
PFKA1_YEASTPFK1genetic
21623372
LONM_YEASTPIM1genetic
21987634
ODPB_YEASTPDB1genetic
21987634
DOP1_YEASTDOP1genetic
21987634
RV167_YEASTRVS167genetic
21987634
ISC1_YEASTISC1genetic
21987634
CDC42_YEASTCDC42genetic
21987634
GEP3_YEASTGEP3genetic
21987634
FAL1_YEASTFAL1genetic
27708008
TFB1_YEASTTFB1genetic
27708008
ACT_YEASTACT1genetic
27708008
BET3_YEASTBET3genetic
27708008
SEA4_YEASTSEA4genetic
27708008
MED5_YEASTNUT1genetic
27708008
SSO2_YEASTSSO2genetic
27708008
CHMU_YEASTARO7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MDHM_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177, AND MASSSPECTROMETRY.

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