| UniProt ID | ISC1_YEAST | |
|---|---|---|
| UniProt AC | P40015 | |
| Protein Name | Inositol phosphosphingolipids phospholipase C | |
| Gene Name | ISC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 477 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. |
|
| Protein Description | Responsible for the hydrolysis of the phosphosphingolipids (IPS), inositol phosphorylceramide (IPC), mannosylinositol phosphorylceramide (MIPC), and mannosyldiinositol phosphorylceramide (M(IP)2C). Also active on sphingomyelin, but this activity is probably not physiologically relevant.. | |
| Protein Sequence | MYNRKDRDVHERKEDGQSEFEALNGTNAIMSDNSKAYSIKFLTFNTWGLKYVSKHRKERLRAIADKLAGHSMLTPISDELLPNGGDSNENEDYDVIALQEIWCVEDWKYLASACASKYPYQRLFHSGILTGPGLAILSKVPIESTFLYRFPINGRPSAVFRGDWYVGKSIAITVLNTGTRPIAIMNSHMHAPYAKQGDAAYLCHRSCQAWDFSRLIKLYRQAGYAVIVVGDLNSRPGSLPHKFLTQEAGLVDSWEQLHGKQDLAVIARLSPLQQLLKGCTTCDSLLNTWRAQRQPDEACRLDYALIDPDFLQTVDAGVRFTERIPHLDCSVSDHFAYSCTLNIVPQGTESRPSTSVKRAKTHDRELILQRYSNYETMIECIHTYLKTAQRQKFFRGLHFWASILLLIASLVVTTFTANKAGWSSIFWVLFAIAVSISGTIDGAISFLFGRSEIRALIEVEQEVLDAEHHLQTFLSEK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 117 | Ubiquitination | LASACASKYPYQRLF HHHHHHCCCCHHHHC | 31.55 | 23749301 | |
| 169 | Phosphorylation | GDWYVGKSIAITVLN CCEECCCEEEEEEEC | 16.01 | 29688323 | |
| 173 | Phosphorylation | VGKSIAITVLNTGTR CCCEEEEEEECCCCC | 15.21 | 29688323 | |
| 177 | Phosphorylation | IAITVLNTGTRPIAI EEEEEECCCCCCEEE | 35.45 | 29688323 | |
| 179 | Phosphorylation | ITVLNTGTRPIAIMN EEEECCCCCCEEEEC | 31.10 | 29688323 | |
| 187 | Phosphorylation | RPIAIMNSHMHAPYA CCEEEECCCCCCCCC | 12.57 | 29688323 | |
| 193 | Phosphorylation | NSHMHAPYAKQGDAA CCCCCCCCCCCCCHH | 27.49 | 29688323 | |
| 270 | Phosphorylation | LAVIARLSPLQQLLK HHHHHHCCHHHHHHC | 20.29 | 19779198 | |
| 350 | Phosphorylation | IVPQGTESRPSTSVK ECCCCCCCCCCCCCC | 49.70 | 27214570 | |
| 354 | Phosphorylation | GTESRPSTSVKRAKT CCCCCCCCCCCCCCC | 39.98 | 27214570 | |
| 361 | Phosphorylation | TSVKRAKTHDRELIL CCCCCCCCCCHHHHH | 28.20 | 27821475 | |
| 371 | Phosphorylation | RELILQRYSNYETMI HHHHHHHHCCHHHHH | 6.57 | 27017623 | |
| 374 | Phosphorylation | ILQRYSNYETMIECI HHHHHCCHHHHHHHH | 13.56 | 27017623 | |
| 383 | Phosphorylation | TMIECIHTYLKTAQR HHHHHHHHHHHHHHH | 15.61 | 27017623 | |
| 384 | Phosphorylation | MIECIHTYLKTAQRQ HHHHHHHHHHHHHHH | 7.64 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ISC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ISC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ISC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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