NOC3_YEAST - dbPTM
NOC3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOC3_YEAST
UniProt AC Q07896
Protein Name Nucleolar complex-associated protein 3
Gene Name NOC3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 663
Subcellular Localization Nucleus, nucleolus .
Protein Description Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Also required for initiation of DNA replication. May function downstream of the origin recognition complex (ORC complex) in the loading of CDC6 and the minichromosome maintenance complex (MCM complex) onto chromatin during the G1 phase of the cell cycle. Essential for growth..
Protein Sequence MAKRNRSQFRIQERTAKKRKHEDSLLEGNVFQNAPEDMDENTIYSAKGSSWDEEEQDYEMVPRKNRSDTSNLVEGLPIKVNGKVERKLHKAQEKPKDDDEEDEDSNDSSEDDEGPNEEQEAEAKEDEPDTEEKILQLKEDIADLVTKVMEEPEENTAALGRLCKMVESKNPNTCKFSMLALVPVFKSIIPGYRIRPLTETEKKEKVSKEVSKLRNFEQALVYNYKNYVGRLQSLSKTPSNAAPIQVSLGILATQAAKELISTASHFNFRTDIFTLLLRRICKPRISTDPTSIQIIQTFETLLNEDEEGSISFEILRIFNKILKTRNFNIEESVLNMLLSLDVLHDYDPNTKLKGNVSAPKLKKKDRVHLSKKQRKARKEMQQIEEEMRNAEQAVSAEERERNQSEILKIVFTIYLNILKNNAKTLIGSVLEGLTKFGNMANFDLLGDFLEVMKELISDTEFDNLSSAEVRKALLCIVSAFSLISNTQYMKVNVDLSKFVDGLYALLPYICLDADIELSYRSLRLADPLNNEIIKPSVNVSTKAELLLKALDHVFFRSKSGTKERATAFTKRLYMCISHTPEKTSIAILKFIDKLMNRYPEISGLYSSEDRIGNGHFIMEADNPSRSNPEAATLWDNALLEKHYCPVVTKGLRSLSSRSKECSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20AcetylationERTAKKRKHEDSLLE
HHHHHHHCCCCCHHC		61.2924489116
24PhosphorylationKKRKHEDSLLEGNVF
HHHCCCCCHHCCCCC		31.6928889911
49PhosphorylationTIYSAKGSSWDEEEQ
CEEECCCCCCCHHHH		27.7825521595
50PhosphorylationIYSAKGSSWDEEEQD
EEECCCCCCCHHHHC		47.4122369663
58PhosphorylationWDEEEQDYEMVPRKN
CCHHHHCCCCCCCCC		12.9630377154
67PhosphorylationMVPRKNRSDTSNLVE
CCCCCCCCCCCCCCC		55.4228889911
69PhosphorylationPRKNRSDTSNLVEGL
CCCCCCCCCCCCCCC		22.2930377154
70PhosphorylationRKNRSDTSNLVEGLP
CCCCCCCCCCCCCCC		32.9121551504
105PhosphorylationDDEEDEDSNDSSEDD
CCCCCCCCCCCCCCC		40.2519795423
108PhosphorylationEDEDSNDSSEDDEGP
CCCCCCCCCCCCCCC		39.6219795423
109PhosphorylationDEDSNDSSEDDEGPN
CCCCCCCCCCCCCCC		48.1619795423
320AcetylationEILRIFNKILKTRNF
HHHHHHHHHHHHCCC		38.3724489116
395PhosphorylationRNAEQAVSAEERERN
HHHHHHHCHHHHHHC		32.7425752575
557PhosphorylationLDHVFFRSKSGTKER
HHHHHHCCCCCCHHH		26.4719823750
559PhosphorylationHVFFRSKSGTKERAT
HHHHCCCCCCHHHHH		53.6019823750
561PhosphorylationFFRSKSGTKERATAF
HHCCCCCCHHHHHHH		36.5019823750
589AcetylationKTSIAILKFIDKLMN
HHHHHHHHHHHHHHH		33.8724489116
656PhosphorylationKGLRSLSSRSKECSK
HHHHHHHHHCCCCCC		45.9628889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NOC3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOC3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOC3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NOC2_YEASTNOC2physical
14759368
NOC3_YEASTNOC3physical
14759368
PUS7_YEASTPUS7physical
14759368
DED1_YEASTDED1physical
14759368
PABP_YEASTPAB1physical
14759368
NOC2_YEASTNOC2physical
11371346
MCM2_YEASTMCM2physical
12110182
ORC1_YEASTORC1physical
12110182
TPS1_YEASTTPS1physical
16554755
YRA1_YEASTYRA1physical
16554755
STM1_YEASTSTM1physical
16554755
NOP2_YEASTNOP2physical
16554755
NOC2_YEASTNOC2physical
16554755
RRS1_YEASTRRS1physical
16554755
PUS7_YEASTPUS7physical
16554755
CCZ1_YEASTCCZ1genetic
20093466
SGF29_YEASTSGF29genetic
20093466
THRC_YEASTTHR4genetic
20093466
RLA1_YEASTRPP1Agenetic
20093466
PP2C1_YEASTPTC1genetic
20093466
NHP10_YEASTNHP10genetic
20093466
SNQ2_YEASTSNQ2genetic
20093466
RT103_YEASTRTT103genetic
20093466
HRQ1_YEASTHRQ1genetic
20093466
SPS2_YEASTSPS2genetic
20093466
RTF1_YEASTRTF1genetic
20093466
CTU1_YEASTNCS6genetic
20093466
RL24A_YEASTRPL24Agenetic
20093466
YOR1_YEASTYOR1genetic
20093466
PRM2_YEASTPRM2genetic
20093466
INP51_YEASTINP51genetic
20093466
YJQ3_YEASTYJL163Cgenetic
20093466
JEM1_YEASTJEM1genetic
20093466
YJH0_YEASTYJL070Cgenetic
20093466
YJB6_YEASTYJL016Wgenetic
20093466
YJ24_YEASTKCH1genetic
20093466
ITPA_YEASTHAM1genetic
20093466
IME1_YEASTIME1genetic
20093466
UBL1_YEASTYUH1genetic
20093466
DAN1_YEASTDAN1genetic
20093466
NDUF7_YEASTYKL162Cgenetic
20093466
NFU1_YEASTNFU1genetic
20093466
PET10_YEASTPET10genetic
20093466
FLO10_YEASTFLO10genetic
20093466
RL37A_YEASTRPL37Agenetic
20093466
UPS1_YEASTUPS1genetic
20093466
SYM1_YEASTSYM1genetic
20093466
SNAPN_YEASTSNN1genetic
20093466
COQ2_YEASTCOQ2genetic
20093466
HMI1_YEASTHMI1genetic
20093466
DFG16_YEASTDFG16genetic
20093466
GGPPS_YEASTBTS1genetic
20093466
IPI3_YEASTIPI3physical
22421151
ORC6_YEASTORC6physical
22421151
ORC5_YEASTORC5physical
22421151
MCM6_YEASTMCM6physical
22421151
CDT1_YEASTTAH11physical
22421151
ATPF_YEASTATP4physical
22875988
SPB1_YEASTSPB1physical
25877921
NOC2_YEASTNOC2physical
25877921
MAK16_YEASTMAK16physical
25877921
EBP2_YEASTEBP2physical
25877921
GPR1_YEASTGPR1genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
SEC17_YEASTSEC17genetic
27708008
CDC53_YEASTCDC53genetic
27708008
DBF4_YEASTDBF4genetic
27708008
MOB2_YEASTMOB2genetic
27708008
MET30_YEASTMET30genetic
27708008
ERB1_YEASTERB1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
YTM1_YEASTYTM1genetic
27708008
VPS8_YEASTVPS8genetic
27708008
ETR1_YEASTETR1genetic
27708008
PEX19_YEASTPEX19genetic
27708008
AIM11_YEASTAIM11genetic
27708008
RIM15_YEASTRIM15genetic
27708008
CTU1_YEASTNCS6genetic
27708008
ADH4_YEASTADH4genetic
27708008
ELP2_YEASTELP2genetic
27708008
TNA1_YEASTTNA1genetic
27708008
UBA4_YEASTUBA4genetic
27708008
KC11_YEASTYCK1genetic
27708008
URM1_YEASTURM1genetic
27708008
CSK21_YEASTCKA1genetic
27708008
HOC1_YEASTHOC1genetic
27708008
MRT4_YEASTMRT4genetic
27708008
KTI12_YEASTKTI12genetic
27708008
ELF1_YEASTELF1genetic
27708008
ELP1_YEASTIKI3genetic
27708008
YPQ1_YEASTYPQ1genetic
27708008
SFL1_YEASTSFL1genetic
27708008
YPK9_YEASTYPK9genetic
27708008
SUR1_YEASTSUR1genetic
27708008
ELP3_YEASTELP3genetic
27708008
ELP4_YEASTELP4genetic
27708008
AXL1_YEASTAXL1genetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NOC3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-50 AND SER-395,AND MASS SPECTROMETRY.

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