CDT1_YEAST - dbPTM
CDT1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDT1_YEAST
UniProt AC P47112
Protein Name Cell division cycle protein CDT1
Gene Name TAH11
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 604
Subcellular Localization Cytoplasm. Nucleus. Undergoes cell cycle-dependent changes in its nuclear localization. Exits the nucleus and remains in the cytoplasm during S phase through early mitosis, and re-accumulates in the nucleus around the end of mitosis.
Protein Description DNA replication licensing factor, required for pre-replication complex assembly. Faithful duplication of the genetic material requires 'once per cell cycle' DNA replication initiation and elongation. Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication. Required for the recruitment of the MCM2-7 helicase complex to the replication origins..
Protein Sequence MSGTANSRRKEVLRVPVIDLNRVSDEEQLLPVVRAILLQHDTFLLKNYANKAVLDALLAGLTTKDLPDTSQGFDANFTGTLPLEDDVWLEQYIFDTDPQLRFDRKCRNESLCSIYSRLFKLGLFFAQLCVKSVVSSAELQDCISTSHYATKLTRYFNDNGSTHDGADAGATVLPTGDDFQYLFERDYVTFLPTGVLTIFPCAKAIRYKPSTMATTDNSWVSIDEPDCLLFHTGTLLARWSQGMHTTSPLQIDPRANIVSLTIWPPLTTPISSKGEGTIANHLLEQQIKAFPKVAQQYYPRELSILRLQDAMKFVKELFTVCETVLSLNALSRSTGVPPELHVLLPQISSMMKRKIVQDDILKLLTIWSDAYVVELNSRGELTMNLPKRDNLTTLTNKSRTLAFVERAESWYQQVIASKDEIMTDVPAFKINKRRSSSNSKTVLSSKVQTKSSNANALNNSRYLANSKENFMYKEKMPDSQANLMDRLRERERRSAALLSQRQKRYQQFLAMKMTQVFDILFSLTRGQPYTETYLSSLIVDSLQDSNNPIGTKEASEILAGLQGILPMDISVHQVDGGLKVYRWNSLDKNRFSKLLQIHKSKQQD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
436PhosphorylationKINKRRSSSNSKTVL
ECCCCCCCCCCCCEE		31.5621440633
437PhosphorylationINKRRSSSNSKTVLS
CCCCCCCCCCCCEEC		46.5019684113
441PhosphorylationRSSSNSKTVLSSKVQ
CCCCCCCCEECCCEE		26.8819684113
445PhosphorylationNSKTVLSSKVQTKSS
CCCCEECCCEECCCC		32.4625533186
451PhosphorylationSSKVQTKSSNANALN
CCCEECCCCCCCHHC		32.0119823750
452PhosphorylationSKVQTKSSNANALNN
CCEECCCCCCCHHCC		41.3319823750
460PhosphorylationNANALNNSRYLANSK
CCCHHCCHHHHHCCC		22.6419823750
462PhosphorylationNALNNSRYLANSKEN
CHHCCHHHHHCCCCC		15.2419823750
466PhosphorylationNSRYLANSKENFMYK
CHHHHHCCCCCCCCC		35.4219823750
479PhosphorylationYKEKMPDSQANLMDR
CCCCCCHHHHHHHHH		25.8924909858
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDT1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDT1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDT1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MCM2_YEASTMCM2physical
11836525
TOP1_YEASTTOP1genetic
11836525
SIC1_YEASTSIC1genetic
11560884
RAD9_YEASTRAD9genetic
11560884
CGS5_YEASTCLB5genetic
11560884
MCM2_YEASTMCM2physical
16824194
MCM3_YEASTMCM3physical
16824194
MCM4_YEASTMCM4physical
16824194
MCM5_YEASTMCM5physical
16824194
MCM6_YEASTMCM6physical
16824194
MCM7_YEASTMCM7physical
16824194
ORC6_YEASTORC6physical
17825064
ORC2_YEASTORC2physical
17825064
ORC5_YEASTORC5physical
17825064
URC2_YEASTURC2physical
18719252
YM01_YEASTYMR111Cphysical
18719252
MDV1_YEASTMDV1physical
18719252
CTF18_YEASTCTF18physical
20980819
MCM6_YEASTMCM6physical
22250202
ORC6_YEASTORC6physical
22250202
MCM2_YEASTMCM2physical
22045335
MCM3_YEASTMCM3physical
22045335
MCM4_YEASTMCM4physical
22045335
MCM5_YEASTMCM5physical
22045335
MCM6_YEASTMCM6physical
22045335
MCM7_YEASTMCM7physical
22045335
ORC4_YEASTORC4physical
22045335
ORC5_YEASTORC5physical
22045335
IPI3_YEASTIPI3physical
22421151
ORC6_YEASTORC6physical
22421151
NOC3_YEASTNOC3physical
22421151
MCM6_YEASTMCM6physical
22421151
MCM2_YEASTMCM2physical
23603117
CYPR_YEASTCPR4genetic
27708008
RPN4_YEASTRPN4genetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
AIR2_YEASTAIR2genetic
27708008
LSM6_YEASTLSM6genetic
27708008
SWI4_YEASTSWI4genetic
27708008
BUD27_YEASTBUD27genetic
27708008
CTU1_YEASTNCS6genetic
27708008
KIP3_YEASTKIP3genetic
27708008
UPF3_YEASTUPF3genetic
27708008
AP18A_YEASTYAP1801genetic
27708008
STB5_YEASTSTB5genetic
27708008
PIG2_YEASTPIG2genetic
27708008
NAP1_YEASTNAP1genetic
27708008
PEX12_YEASTPEX12genetic
27708008
GBLP_YEASTASC1genetic
27708008
SAP30_YEASTSAP30genetic
27708008
CYB5_YEASTCYB5genetic
27708008
RRP6_YEASTRRP6genetic
27708008
SKI7_YEASTSKI7genetic
27708008
RAD1_YEASTRAD1genetic
27708008
SKI3_YEASTSKI3genetic
27708008
TRS20_YEASTTRS20genetic
27708008
CDC1_YEASTCDC1genetic
27708008
TRS23_YEASTTRS23genetic
27708008
BRL1_YEASTBRL1genetic
27708008
PRI2_YEASTPRI2genetic
27708008
ORC1_YEASTORC1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
IWS1_YEASTSPN1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
ORC4_YEASTORC4genetic
27708008
PRP4_YEASTPRP4genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
DCC1_YEASTDCC1genetic
27708008
MRC1_YEASTMRC1genetic
27708008
PER1_YEASTPER1genetic
27708008
ATG15_YEASTATG15genetic
27708008
YCZ2_YEASTYCR102Cgenetic
27708008
PP2C1_YEASTPTC1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
MBP1_YEASTMBP1genetic
27708008
RM01_YEASTMRPL1genetic
27708008
SAC3_YEASTSAC3genetic
27708008
SAY1_YEASTSAY1genetic
27708008
ATG32_YEASTATG32genetic
27708008
MDM35_YEASTMDM35genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
NNK1_YEASTNNK1genetic
27708008
VPS51_YEASTVPS51genetic
27708008
DBP7_YEASTDBP7genetic
27708008
SIS2_YEASTSIS2genetic
27708008
NU133_YEASTNUP133genetic
27708008
LAM6_YEASTYLR072Wgenetic
27708008
ARP6_YEASTARP6genetic
27708008
ACE2_YEASTACE2genetic
27708008
YL177_YEASTYLR177Wgenetic
27708008
CPYI_YEASTTFS1genetic
27708008
YL194_YEASTYLR194Cgenetic
27708008
HMX1_YEASTHMX1genetic
27708008
ARV1_YEASTARV1genetic
27708008
UNG_YEASTUNG1genetic
27708008
TSA1_YEASTTSA1genetic
27708008
PRM6_YEASTPRM6genetic
27708008
RS3A2_YEASTRPS1Bgenetic
27708008
PYRE_YEASTURA5genetic
27708008
MAC1_YEASTMAC1genetic
27708008
UBC7_YEASTUBC7genetic
27708008
YMS4_YEASTYMR034Cgenetic
27708008
CTF18_YEASTCTF18genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
MRE11_YEASTMRE11genetic
27708008
TRI1_YEASTTRI1genetic
27708008
HRB1_YEASTHRB1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
HST3_YEASTHST3genetic
27708008
KPYK2_YEASTPYK2genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
CBS_HUMANCBSphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDT1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466, AND MASSSPECTROMETRY.

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