dbPTM

SAY1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SAY1_YEAST
UniProt AC	P53324
Protein Name	Steryl acetyl hydrolase 1
Gene Name	SAY1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	424
Subcellular Localization	Endoplasmic reticulum membrane Single-pass type II membrane protein .
Protein Description	Required for the deacetylation of acetylated sterols. Involved in the resistance to eugenol and pregnenolone toxicity..
Protein Sequence	MAANSGLDSKVEYYRLQENEIISAVSSEDADQNDAGFRLSTIHLHLFHGLKFAALLFTVVPVFIILDSMKIIFQRKRRFCLDHVNRSFLRQSSWILDERICQYVLNPLFVCLYPSTFSSPTYVKCNIPIEDQKSPENNIFQDHQLNAPKIVSTKFYQYVMPEGFDPTTDPVLVFYHGGGYALKLTPTSFSFLNNMRNAFPKMAILVPDYTVTATDDQSKKYPLQILQNVAIFDYVVKTMGCKNVVIMGDSAGGNAVLNIVLYLRKCHREIYPKKVIAISPWANATFFHEGEKEYMQGTQEWDGLCLKSHSMFGRMFVGNNPNVDFTSDPFVNIEKNFETKMWQDILKKCSVMITYGSDELLSFQNKILAKKMSDASEGCNHFTAKNVLVEHQGYHTGPILNYSRNMDRWTNIPSIARILEFMQS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAANSGLDS ------CCCCCCCCC	18.49	22814378
10	Ubiquitination	ANSGLDSKVEYYRLQ CCCCCCCCCEEEECC	38.46	24961812
85	N-linked_Glycosylation	RFCLDHVNRSFLRQS HHHHHHHCHHHHHHH	30.38	-
283	N-linked_Glycosylation	IAISPWANATFFHEG EEECCCCCCCEECCC	35.33	-
401	N-linked_Glycosylation	YHTGPILNYSRNMDR CCCCCCCCCCCCCCC	33.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SAY1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SAY1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SAY1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERG2_YEAST	ERG2	genetic	16269340
CHO2_YEAST	CHO2	genetic	16269340
GST1_YEAST	GTT1	genetic	16269340
PFD2_YEAST	GIM4	genetic	16269340
COPD_YEAST	RET2	genetic	16269340
GAS1_YEAST	GAS1	genetic	16269340
AP3M_YEAST	APM3	genetic	16269340
TED1_YEAST	TED1	genetic	16269340
PGA3_YEAST	PGA3	genetic	16269340
MOT3_YEAST	MOT3	physical	18719252
PRS7_YEAST	RPT1	genetic	27708008
FABG_YEAST	OAR1	genetic	27708008
KPC1_YEAST	PKC1	genetic	27708008
EXO70_YEAST	EXO70	genetic	27708008
CDC11_YEAST	CDC11	genetic	27708008
PRP19_YEAST	PRP19	genetic	27708008
SEN1_YEAST	SEN1	genetic	27708008
IPL1_YEAST	IPL1	genetic	27708008
THRC_YEAST	THR4	genetic	27708008
VMS1_YEAST	VMS1	genetic	27708008
RRP8_YEAST	RRP8	genetic	27708008
CEM1_YEAST	CEM1	genetic	27708008
OPI1_YEAST	OPI1	genetic	27708008
HTD2_YEAST	HTD2	genetic	27708008
YJY1_YEAST	YJR011C	genetic	27708008
DHOM_YEAST	HOM6	genetic	27708008
ELF1_YEAST	ELF1	genetic	27708008
NNK1_YEAST	NNK1	genetic	27708008
SAC1_YEAST	SAC1	genetic	27708008
ENT2_YEAST	ENT2	genetic	27708008
ERG6_YEAST	ERG6	genetic	27708008
PET8_YEAST	PET8	genetic	27708008
OCA2_YEAST	OCA2	genetic	27708008
BRE5_YEAST	BRE5	genetic	27708008
ARL3_YEAST	ARL3	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SAY1_YEAST

Related Literatures of Post-Translational Modification